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1
題名:Self-Regulation of Mouse p45/NF-E2 during Murine Erythroleukemia Cell Differentiation    
著者:Tung-Liang LeeShau-Ching WenWei-Yuan HsiaoChe-Kun James ShenYu-Chiau Shyu
出版地區:台灣
出版城市:台北市
學科:生命科學 ; 醫學綜合
關鍵字:Bach1 ; MEL ; MARE ; ChIP ; GATA-1
刊名:Zoological Studies
頁碼:362-369
語言:英語
摘要: 英文摘要PDF

The complicated process of murine erythroleukemia (MEL) cell differentiation is precisely controlled by a group of transcription factors. One of those transcription factors, p45/NF-E2, is important for globin gene expression. We analyzed the structure of the mouse p45 gene which contains a putative nuclear factor erythroid-derived 2 (NF-E2) which binds to the Maf recognition element (MARE) located upstream of the erythroid-specific p45 promoter. Chromatin immunoprecipitation (ChIP) assays showed that p45/NF-E2 bound to this MARE-like region during the period of dimethyl sulfoxide (DMSO)-induced MEL differentiation. Moreover, the ChIP analysis also showed that p45/NF-E2 binding to the GATA-1 binding region of the erythroidspecific p45 promoter was similar to the binding to the MARE-like region. Analysis of the p45 expression profile corresponded to the p45 promoter binding capacity of p45/NF-E2 during MEL cell differentiation. This evidence suggests that the MARE-like binding site might function as an enhancer that interacts with the GATA-1 binding motif within the p45 promoter to mediate the upregulation of p45 mRNA in erythroid differentiation. Furthermore, we also found that the MARE binding repressor, Bach1, did not bind to the p45 promoter, thus excluding any involvement of Bach1 in p45 gene regulation before MEL differentiation. Together these results suggest that p45/NF-E2 self-regulation is a positive enhancer regulatory mechanism, which differs from the MARE-dependent regulatory mechanism that contributes to the rapid upregulation of p45/NF-E2 required for erythroid differentiation.


    

本卷期目次
Zoological Studies
Photoperiodic Regulation of Reproductive Activity in Summer-and Autumn-Morph Butterflies of Polygonia c-aureum L./ Keijiro FujitaMoeko InoueMasao WatanabeAbu Taher Md. Fayezul IslamReza Md. ShahjahanKatsuhiko EndoAkira Yamanaka
Analyzing Insect Community Structure through the Application of Taxonomic Distinctness Measures/ Laura Banos-PiconJosep D. AsisSeveriano F. GayuboJose Tormos
A Growth Check Deposited at Estuarine Arrival in Otoliths of Juvenile Flathead Mullet (Mugil cephalus L.)/ Chih-Chieh HsuChih-Wei ChangYoshiyuki IizukaWann-Nian Tzeng
Characterization of Sounds of the Blackspotted Croaker Protonibea diacanthus (Sciaenidae) and Localization of Its Spawning Sites in Estuarine Coastal Waters of Taiwan/ Hin-Kiu MokHsin-Yi YuJinn-Pyng UengRuey-Chang Wei
Effects of Body Size, Operational Sex Ratio, and Age on Pairing by the Asian Toad, Bufo stejnegeri/ Jung-Hyun LeeDaesik Park
Colonization of Forest Elephant Dung by Invertebrates in the Bossematie Forest Reserve, Ivory Coast/ Jorn TheuerkaufSophie RouysArno L. van Berge HenegouwenFrank-Thorsten KrellS?awomir MazurMichael Muhlenberg
Sexual Size and Shape Dimorphism in an Agamid Lizard, Japalura swinhonis (Squamata: Lacertilia: Agamidae)/ Chi-Yun KuoYu-Teh LinYao-Sung Lin
Self-Regulation of Mouse p45/NF-E2 during Murine Erythroleukemia Cell Differentiation/ Tung-Liang LeeShau-Ching WenWei-Yuan HsiaoChe-Kun James ShenYu-Chiau Shyu
Chaetopterid Polychaetes from Taiwan and Okinawa Island (Japan), with Descriptions of Two New Species/ Eijiroh NishiHwey-Lian Hsieh
Two New Species of Acanthocyclops Kiefer, 1927 (Copepoda: Cyclopoida: Cyclopinae) with Pilose Caudal Rami from Semiarid Areas of Mexico/ Nancy F. Mercado-SalasEduardo Suarez-MoralesMarcelo Silva-Briano
A New Species of the Batfish Genus Malthopsis (Lophiiformes: Ogcocephalidae) from the Northwestern Indian Ocean/ Hsuan-Ching HoArtem M. ProkofievKwang-Tsao Shao
Five New Indo-Pacific Lizardfishes of the Genus Synodus (Aulopiformes: Synodontidae)/ John E. Randall
Identifying Biodiversity Hotspots by Predictive Models: A Case Study Using Taiwan's Endemic Bird Species/ Chia-Ying KoRuey-Shing LinTzung-Su DingChih-Hao HsiehPei-Fen Lee
 
   
 
   

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