原名「台灣學術線上」
包含TAO期刊庫 + TAO書籍庫 + 論文 + 史料文獻
首頁 | 關於TAO | 瀏覽 | 進階查詢 | 參考工具 | 會員服務 | 已購專書 | RSS服務 | 電子報 | FAQ  
查詢範圍:
   
查詢模式:
熱門查詢詞:
老人需求dvdPerception直播
   
   
   
     
   
 
項次 書目
1
題名:Aggressive Gastrointestinal Stromal Tumor Associated with Pituitary Acromegaly    
肢端肥大症合併高度惡性表現的胃腸道基質瘤
著者:Hung-Yu Chien(簡鴻宇) ;Lon-Shyong Lee(李龍雄) ;Sheng-Huang Hsiao(蕭勝煌)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:肢端肥大症 ; 胃腸道基質瘤 ; 第一型類胰島素生長因子 ; acromegaly ; gastrointestinal stromal tumor ; insulin-like growth factor
刊名:Journal of the Chinese Oncology Society
頁碼:461-468
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

此篇病例報告中,我們報告一位在接受內視鏡檢查治療後7個月再次復發解血便的52歲男性病患。腹部電腦斷層攝影檢查發現於迴腸末端疑似胃腸道基質瘤的4.7公分腫瘤。經開腹手術切除後病理切片及免疫染色證實為胃腸道基質瘤。後因之前健檢意外發現的腦下垂體腫瘤而轉介至內分泌科門診,在此之前因無症狀病患未曾接受進一步檢查,病人的外觀呈現疑似肢端肥大症的臉部特徵且血清中生長激素,第一型類胰島素生長因子及葡萄糖耐受性試驗皆呈現肢端肥大症的表現,在接受經鼻內視鏡經蝶竇手術亦證實為腦下垂體巨腺瘤所導致的肢端肥大症。令人訝異的於開腹手術後的2個月時於腹部超音波追蹤檢查時發現一顆之前無跡象的2.2公分低迴音性肝臟腫瘤,並於正子斷層攝影時呈現高信號而臨床上斷定為胃腸道基質瘤的轉移腫瘤。這是一個臨床少見具高侵襲性及高度惡性表現的胃腸道基質瘤,可能是透過肢端肥大症的血液中高濃度第一型類胰島素生長因子異常刺激於胃腸道基質瘤c-kit tyrosine kinase變異而持續活化的mitogen-activated protein kinase(MAPK)及phosphatidylinositol 3 kinase(PI3K)共同訊息通路所導致的細胞迅速增生。
In this case report, we report a 52-year-old man presented with repeated hematochezia separated by a 7-month interval. Computed tomography (CT) showed a 4.7-cm mildly enhanced tumor at the distal ileum suggestive of gastrointestinal stromal tumor (GIST). Diagnosis of GIST was confirmed from typical histological and immunohistochemical staining after laparotomy segmental resection of the tumor at the distal ileum. Endocrinology clinic referral for a previous incidentally found pituitary tumor pointed to pituitary acromegaly owing to acromegalic appearance which was appreciated biochemically by elevated random growth hormone (GH), glucose tolerance test (GTT), elevated insulin-like growth factor-1 (IGF-1) and histopathologically after transsphenoidal adenomectomy. Suprisingly, just two months after the laparotomy surgery, a 2.2-cm hypoechoic liver nodule with increased uptake by positron emission tomography (PET) was detected which was not evident in the latest image studies. This is an unusual case with intense aggressive and malignant behavior of the GIST that could be stimulated by high IGF-1 concentrations associated with acromegaly through the activation of MAPK and PI3K bypassing KIT tyrosine kinase which underlies GIST.


    

本卷期目次
Journal of the Chinese Oncology Society
Revisiting Squamous Cell Carcinoma of the Lungs-A Disease Given Less Attention/ Yuh-Min ChenJen-Fu ShihChun-Ming TsaiYu-Chin LeeReury-Perng PerngJacqueline Whang-Peng
Pemetrexed Followed by Docetaxel or a Reverse Sequence in Non-Small-Cell Lung Cancer/ Wen-Chien FanYuh-Min ChenJen-Fu ShihYu-Chin LeeReury-Perng Perng
Ganoderma Triterpenoid Ganoderic Acid T Inhibits Growth and Metastasis of A549 Lung Adenocarcinoma In Vitro and In Vivo/ Hsiao-Hsuan LaiCheng-Po HuangDeng-Hai ChenKuan-Dee ChenShwu-Bin Lin
胃部瀰漫性大B型淋巴瘤於R-CHOP的治療年代:單一醫學中心之經驗/ 陳苓萍蔡碧桐余明生林世哲
護理人員對癌症臨床試驗的知識與態度及其相關因素之探討/ 張杏焄封威蓮鍾佩珊朱正玉彭汪嘉康賴裕和
Recovery from Gefitinib-induced Pneumonitis and Hepatitis after Changing to Erlotinib Treatment/ Chun-Chang LiuYuh-Min Chen
Intramedullary Sarcoidosis/ Ying-Chih ChenSheng-Jean HuangAbel Po-Hao HuangYu-Ting TsengLong-Wei LinYong-Kwang TuLu-Ting Kuo
Suprasellar Metastasis of Pulmonary Adenocarcinoma/ Jen-Ho TsengSheng-Huang HsiaoJung-Mao ChouAnn-Jeng Liu
Aggressive Gastrointestinal Stromal Tumor Associated with Pituitary Acromegaly/ Hung-Yu ChienLon-Shyong LeeSheng-Huang Hsiao
Malignant Thyroid Teratoma with Aggressive Neck and Intrathoracic Disseminations/ Wei-Chun LoShi-Ping LuhDong-Long WuMao-Te Chuang
 
   
 
   

與TAO合作 | 隱私與版權聲明 | 聯絡方式 | 下載Adobe Reader
地址:台北市中正區(100)北平東路30-12號3樓
電話:(02)2393-6968 傳真:(02)2393-6877
Email: service@wordpedia.com
Wordpedia Family: 學校、企業版入口 | 遠流影音館
Copyright©2011 Wordpedia Co., Ltd. All Rights Reserved.