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1
題名:Cancer Stem Cells and Sonic Hedgehog Signaling in Head and Neck Cancer: Potential Targets for Overcoming Chemoradiation Resistance    
頭頸癌之癌症幹細胞與Sonic Hedgehog訊息傳導:具克服放射化學治療抵抗性潛力之標靶
著者:Yu-Jen Chen(陳裕仁) ;Yi-Fen Wang(王怡芬) ;K. S. Clifford Chao(趙坤山)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:癌症幹細胞 ; 放射化學治療 ; 抵抗性 ; Cancer stem cell ; Sonic hedgehog ; Chemoradiation ; Resistance
刊名:Journal of the Chinese Oncology Society
頁碼:81-88
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

癌症幹細胞是具備自我更新及分化能力且對放射及化學治療較不敏感之一小群特殊癌細胞。Sonic Hedgehog (SHH)及其相關訊息傳導分子對胚胎發育非常重要,並且能調節包括癌症幹細胞等多種幹細胞之增生及分化。本文將簡介SHH訊息傳導路徑,扼要說明其與癌症治療抵抗性之關連,並討論如何利用標靶於SHH路徑以克服治療抵抗性之近期研究發展。 我們藉此提出利用標靶於SHH訊息傳導路徑以克服頭頸癌放射及化學治療抵抗性之假說。此假說經本院頭頸癌聯合治療小組研究中。
Cancer stem cells (CSC) are a small and distinct population of cancer cells that possess self-renewal and differentiation ability and are relatively resistant to treatment including chemotherapy and radiotherapy. Sonic hedgehog (SHH) and related signaling molecules are critical to embryonic development and regulate both proliferation and differentiation of various types of stem cells, including CSC. This article provides a brief overview of the SHH signaling pathway, summarizes the correlation between SHH signaling and treatment resistance of cancer cells and discusses the recent advances in targeting this signaling cascade to overcome treatment resistance. We proposed that CSC and their related the SHH signaling pathway might be potential targets for overcoming chemoradiation resistance of head and neck cancer cells. This has been under investigation by our comprehensive team treating head and neck cancers.


    

本卷期目次
Journal of the Chinese Oncology Society
Carcinoma in the Pharynx: Nasopharynx, Oropharynx and Hypopharynx/ Yi-Shing LeuJehn-Chuan Lee
肝癌術後早期復發的危險因子的探討/ 蔡樹榮陳銘仁張文熊施壽全王鴻源王蒼恩
補充麩胺酸以預防子宮頸癌患者接受化療合併放射治療中引發急性腹瀉的效用評估/ 吳孟浩陳裕仁
Rapidly Progression to Hepatic Failure in Hepatocellular Carcinoma/ Chen-Wang ChangWen-Hsiung ChangShou-Chuan ShihMing-Jen ChenChia-Yuan LiuI-Tsung LinShu-Jung Tsai
Pituitary Apoplexy Following Mild Head Injury Mimicking Bacterial Meningitis/ Lin ChangJen-Ho TsengMuh-Yong YenCherng-Lan JeangSheng-Huang Hsiao
Retroperitoneal Teratoma with Malignant Transformation of Primitive Neuroectodermal Tumor/ Yih-Cherng DuhNei-Lu WangJin-Cherng Sheu
Superior Mesenteric Vein Injury During Right Hemicolectomy for Transverse Colon Cancer/ Ching-Kuo YangChien-Kuo Liu
Original Plexiform Fibrohistiocytic Tumors on Both Thighs/ Chin-Hung WeiNien-Lu WangBe-Fong Chen
Cancer Stem Cells and Sonic Hedgehog Signaling in Head and Neck Cancer: Potential Targets for Overcoming Chemoradiation Resistance/ Yu-Jen ChenYi-Fen WangK. S. Clifford Chao
Biomarkers in Diagnostic Head and Neck Tumor Pathology/ Chi-Kuan Chen
 
   
 
   

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