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1
題名:Docetaxel, Cisplatin and 5-Fluorouracil in Patients with Refractory, Recurrent, or Metastatic Squamous Cell Carcinoma of the Head and Neck    
以Docetaxel, Cisplatin和5-Fluorouracil治療頑固、復發、或遠處轉移的頭頸部鱗狀上皮細胞癌病人
著者:Yi-Fang Chang(張義芳) ;Ya-Ping Lin(林雅萍) ;Nai-Wen Su(蘇迺文) ;Yi-Shing Leu(呂宜興) ;Yu-Jen Chen(陳裕仁) ;Chung-Ji Liu(劉崇基)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:頑固性頭頸癌 ; 復發性頭頸癌 ; 遠處轉移頭頸癌 ; 順鉑 ; refractory ; recurrent ; metastatic ; head and neck ; docetaxel ; 5-fluorouracil ; cisplatin
刊名:Journal of the Chinese Oncology Society
頁碼:336-344
語言:英語
摘要:
背景:回顧研究以docetaxel,cisplatin,和5-fluorouracil來治療頑固性、復發、或有遠處轉移的頭頸部鱗狀上皮細胞癌病人。 病人和研究方法:我們回溯了25個合乎診斷是治療頑固性、復發或有遠處轉移的頭頸部鱗狀上皮細胞癌病人。其中有18個病人過去曾做過手術切除治療,且所有25個病人都曾經接受過化學藥物合併放射線治療,以及包含了cisplatin合併5-FU在內的化學藥物治療。這些病人都無法再做手術或局部的放射線治療。對於這樣的病人我們給予docetaxel加上cisplatin合併5-fluorouracil (TPF)的處方作為姑息性的化學藥物治療。其使用劑量如下:docetaxel第一天給予50mg/m2;cisplatin也是在第一天給予50mg/m2;而5-fluorouracil則以500mg/m2/d給予3-5天。處方是以28天為一週期給予。 結果:25個病人總共接受了78次docetaxel加上cisplatin合併5-fluorouracil的處方治療。平均每人有三次以上的療程。主要的治療毒性是對於骨髓的抑制,有52%的病人在治療期間曾發生過第三或第四級的中性白血球低下情況。有一病例由於嚴重的中性白血球低下而導致敗血症死亡。對於治療的結果,雖然沒有病人得到完全緩解,但有40%的病人是有局部的治療反應,而有32%的病人維持疾病穩定。平均存活時間為38周,可以存活超過一年的病人有28%。 結論:我們回顧研究的結果認為:對於治療頑固性或復發或有遠處轉移的頭頸鱗狀上皮細胞癌病人,如果他們有好的日常體能狀態,那麼作為一個姑息性治療,較低劑量的docetaxel加上cisplatin合併5-fluorouracil是一個有治療效果而藥物毒性又可接受的處方。
Background: This study retrospectively investigated the effects of one chemotherapy regimen-docetaxel, cisplatin, and 5-fluorouracil- in the treatment of patients with refractory, recurrent, or metastatic squamous cell carcinoma of the head and neck. Patients and Methods: We reviewed the medical history of 25 patients diagnosed with refractory, recurrent, or metastatic squamous cell carcinoma of the head and neck. Eightteen of the 25 patients had tumor resection, while all 25 patients received concurrent chemoradiotherapy with cisplatin and 5-FU as the primary therapy. For the 25 patients who had recurrent tumors that were unable to undergo further surgery or local radiotherapy, we applied a regimen consisting of docetaxel, cisplatin, and 5-fluorouracil (TPF) as palliative chemotherapy. The dosage was: docetaxel 50 mg/m2 and cisplatin 50 mg/m2 on day 1, followed by 5-fluorouracil 500 mg/m2 per day for 3-5 days. This regimen was repeated every 28 days. Results: Twenty-five patients received a total 78 cycles of chemotherapy with the regimen docetaxel, cisplatin, and 5-fluorouracil. Each patient was given at least three cycles of chemotherapy on average. The main manifestation of toxicity was marrow suppression. Fifty-two percent of patients had Grade 3 or Grade 4 neutropenia during treatment. One patient died from septicemia associated with severe neutropenia. No complete response was achieved and 40% of patients had partial response, while 32% of patients obtained a stable disease condition. Median overall survival time was 38 weeks. Twenty-eight percent of patients survived for more than one year. Conclusions: As a palliative chemotherapy regimen, the dosing schedule of docetaxel, cisplatin, and 5-fluorouracil used in this study demonstrated its effectiveness and was well tolerated in patients with refractory, recurrent, or metastatic squamous cell carcinoma of the head and neck.


    

本卷期目次
Journal of the Chinese Oncology Society
Deep into the Cancer Metastasis and Development: TWIST Activation by Hypoxia-Inducible Factor-1/ Yao-Yu HsiehMuh-Hwa Yang
Plasma Cell Myeloma in Southern Taiwan-Experience in a Single Institution/ Ling-Ping ChenShyh-Jer LinMing-Sun Yu
Docetaxel, Cisplatin and 5-Fluorouracil in Patients with Refractory, Recurrent, or Metastatic Squamous Cell Carcinoma of the Head and Neck/ Yi-Fang ChangYa-Ping LinNai-Wen SuYi-Shing LeuYu-Jen ChenChung-Ji Liu
5-Aminosalicylic Acid Enema Potentially Helpful for Radiation Proctitis Patients Responding Poorly to Steroid Enemas/ Tsung-Cheng ChuehTzu-An Chen
以詞的關聯性為基礎之文件自動分類系統應用於網路癌症衛教資訊分類/ 陳妍妤詹智凱劉立徐建業
Intrathecal Trastuzumab for Meningeal Carcinomatosis Secondary to HER2-Overexpressing Breast Cancer/ Yen-Hsun ChenWei-Shiou HwangChao-Hsun ChenChao-Jung TasoWen-Tsung HuangMing-Hsien LinYin-Hsun FengChien-Liang LinCheng-Yao LinShang-Wen ChenShang-Hung Chen
Primary Central Nervous System Lymphoma with Tumoral Bleeding and Intraocular Involvement/ He-Shu KuCheng-Kuei ChangMing-Fu ChiangShiu-Jau ChenSheng-Yu ChengJui-Feng LinHung-Shih LinCheng-Chia Tsai
Delayed Traumatic Rupture of Splenic Angiosarcoma/ Ching-Lung HsiehChien-Liang LiuTsang-Pai LiuTao-Yeuan WangJie-Jen Lee
Primary Intraosseous Meningioma/ Chung-Yu WenYih-Yiing WuJing-Shan HuangChih-Ju Chang
一位年輕盲腸腺癌病患以急性闌尾炎為表徵/ 莊樹宏林?彬劉建國王道遠陳碧芳李居仁
 
   
 
   

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