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1
題名:POLYMERASE CHAIN REACTION IN THE DIAGNOSIS OF GASTRIC MALT LYMPHOMA AS ATYPICAL LYMPHOCYTIC INFILTRATES: A CASE REPORT    
多?脢鏈反應用於診斷以非典型淋巴浸潤作表現的胃黏膜相關淋巴組織淋巴瘤-病例報告
著者:Huan-Chau Lin(林煥超) ;Johnson Lin(林炯森) ;Ken-Hong Lim(林建鴻) ;Ruey-Kuen Hsieh(謝瑞坤) ;Ming-Jer Huang(黃明哲) ;Yi-Fang Chang(張義芳) ;Ming-Chih Chang(張明志) ;Chia-Yuan Liu(劉家源) ;Chin-Yuan Tzen(曾嶔元)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:gastric MALT lymphoma ; Polymerase clain reaction ; Monoclonallty ; Hypertrophic gastritis
刊名:Journal of the Chinese Oncology Society
頁碼:1-6
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

胃的黏膜相關淋巴組織淋巴瘤主要是經由內視鏡發現可疑病灶而經病理檢查確定診斷。但對於以非典型淋巴浸潤的病理表現而欲作出早期診斷對病理科醫師是一個很大的挑戰。我們報告一位51歲的男性,臨床表現出上腹痛症狀而胃鏡檢查發現有肥厚性胃炎的病人。初次及重覆的胃鏡切片顯示黏膜下有非典型淋巴球浸潤病灶。在懷疑惡性淋巴瘤可能性下,經過多?脢鏈反應(PCR)來評估病灶的單株性,結果顯示免疫球蛋白重鍊單株性(immunoglobulin heavy chain monoclonality)而確立淋巴瘤的診斷,病人經幽門螺旋桿菌根除療法之後,在追蹤的胃部病理切片中顯示淋巴瘤病灶消失。 因此,我們認為在伴隨著病理組織的檢查下,多?脢鏈反應來可幫助偵測疑似病灶的單株性,這對胃的黏膜相關淋巴組織淋巴瘤扮演著輔助性診斷的角色。而單株性仍可能在病灶經治療消失後仍存在,臨床上須持續長期追蹤。
Gastric mucosa-associated lymphoid tissur (MALT) lymphoma is mainly diagnosed by endoscopic biopsy. It is a challenge for pathologists to establish an early diagnosis once an atypical lymphocytic infiltrate is found. We reported a 51-year-old male presenting upper abdominal pain with gastroscopic finding of hypertrophic gastritis. Initial and repeated endoscopic biopsy revealed the atypical lymphocytic infiltrates in the submucosa. Due to the suspicion of lymphoid malignancy, we used polymerase chain reaction (PCR) to assess the monoclonality of these lesions. The results demonstrated the monoclonal band of heavy chain in immunoglobulin and the pathological diagnosis of lymphoma was confirmed. H. pylori eradication was initiated and histological regression was achievedin follow-up biopsy. In addition to regular pathological examination, PCR can help to detect the monoclonality of the suspected lesions. So it would provide an adjunctive role in molecular diagnosis of gastric lymphoid neoplasm which turn out to be a MALT lymphoma in this case. The monocloality may persist after H. pylori eradication with disappearance of the lesion and long term follow-up is warranted.




本卷期目次
Journal of the Chinese Oncology Society
POLYMERASE CHAIN REACTION IN THE DIAGNOSIS OF GASTRIC MALT LYMPHOMA AS ATYPICAL LYMPHOCYTIC INFILTRATES: A CASE REPORT/ Huan-Chau LinJohnson LinKen-Hong LimRuey-Kuen HsiehMing-Jer HuangYi-Fang ChangMing-Chih ChangChia-Yuan LiuChin-Yuan Tzen
臺灣癌症中心病人面向的照護品質探討/ 唐秀治陳美伶鍾國彪賴美淑鄭守夏邱秀渝邱昭華孔憲蘭蕭淑純
 
   
 
   

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