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1
題名:Treatment Outcome in Oropharyngeal Carcinoma-Preliminary Report    
初步報告-口咽癌治療結果分析
著者:Chih-Yung Yang(楊志雍) ;Yi-Shing Leu(呂宜興) ;Jehn-Chuan Lee(李振川) ;Yi-Fang Chang(張義芳) ;Min-Jer Huang(黃明哲) ;Yu-Jen Chen(陳裕仁) ;Hong-Wen Chen(陳虹汶) ;Hung-Tao Hsiao(蕭弘道) ;Chung-Ji Liu(劉崇基)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:鱗狀上皮細胞癌 ; 口咽癌 ; 同步電化療 ; Squamous cell carcinoma ; oropharyngeal carcinoma ; concurrent chemoradiotherapy
刊名:Journal of the Chinese Oncology Society
頁碼:10-16
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:口咽癌相對於其他頭頸部癌症而言雖較為少見,但治療的方式卻在近年被熱烈討論。同步執行放射治療及化學治療(Concurrent Chemoradiotherapy CCRT)為頭頸癌新興之治療方式並且已與手術同樣成為第一線治療之選項。本文將分享本院治療口咽癌之經驗。 方法:本研究回溯本院自2002年至2006年診斷並收治之口咽癌之35名患者。統計資料包含年齡、腫瘤位置分期、發病年齡、以及結果並以RECIST方法評估療效。35名病患均直接接受CCRT.治療完畢後半年內每位病患均每月返診追蹤並在之後每三個月接受定期追蹤。 結果:本院於2002年至2006年間口腔癌患者共35人,其中扁桃腺癌共19人、軟顎癌共5人及舌根癌共11人。平均發病年齡為52.16歲,平均追蹤期為29.04月,最初診斷時並無病患發生遠端轉移,其中8名病患化療劑量因受藥物毒性影響而降低,兩年存活率為66.62%,其中各分期之存活率分布自16.67至100%不等。以RECIST法評估療效,共40%之病患腫瘤完全消失,治療後追蹤共3人發現遠端轉移,1人在治療後29個月後發現局部復發,比較減低化療劑量病患之良好反應率與接受正常劑量患者並無顯著差距。 結論:本文提供了本院治療口咽癌之經驗。根據此研究結果發現因副作用而降低化學治療劑量在良好反應率方面並無顯著影響。建議病患如無法承受高劑量化學治療時應適當降低劑量。
Purpose: The aim of this study is to assess the result and the effect of concurrent chemoradio-therapy for oropharyngeal carcinoma. Materials and Methods: A retrospective survey of patients who underwent chemotherapy and radiation for oropharyngeal carcinoma at Mackay Memorial Hospital. Collected data include age, tumor site, therapy protocol and result of the treatment, which is assessed with RECIST method. Results: Totally 35 patients were diagnosed with oropharyngeal carcinoma during 2002 and 2006; the average age at diagnosis was 52.16 years and the average follow up period was 29.09 months. No distant metastasis was found at diagnosis. Eight patients received decreased chemotherapic dosage due to toxic effect. Overall 2-year survival rate was 66.62% and the survival rate between each stage was ranged from 16.67% to 100%. Complete remission was observed on 14 patients (40.0%). Distant metastasis after treatment was found on 3 patients and local recurrence was found on 1 patient. No significant difference of the well-response rate between the patients who received full dosage of chemotherapy and those who received decreased dosage. Conclusions: In this article we present the experience for the treatment of the oropharyngeal carcinoma. The suggested policies of management in oropharyngeal carcinoma is concurrent chemoradiation in priority. There is no negative effect in reduced dosage of chemotherapy with less side effect.




本卷期目次
Journal of the Chinese Oncology Society
Treatment Outcome in Oropharyngeal Carcinoma-Preliminary Report/ Chih-Yung YangYi-Shing LeuJehn-Chuan LeeYi-Fang ChangMin-Jer HuangYu-Jen ChenHong-Wen ChenHung-Tao HsiaoChung-Ji Liu
Carcinoid Tumors of the Appendix-Experience in a Teaching Hospital/ Jiunn-Chang LinTsang-Pai LiuJee-Jen LeeChien-Liang LiuTsen-Long Yang
Transanal Local Excision of Rectal Malignant Neoplasms/ Wai-Hung LeungMing-Jen Chen
Local Anesthesia to Improve Postoperative Outcome for Breast Cancer Surgery: Preliminary Results/ Chung-Hsin TsaiYung-Wei HsuShih-Ping ChengChien-Liang LiuTsen-Long YangChun-Yueh LinYuan-Ching Chang
電腦刀立體定位放射性手術於治療第一型及第二型聽神經腫瘤之研究/ 林乾閔蔡若婷林牧熹林家瑋蘇鈺凱柯宗伯魏立邱文達張丞圭葉宜憲
家族性甲狀腺癌/ 鄭世平楊圳隆鄭國祥劉建良李居仁劉滄柏
影響臺灣地區非安寧照顧下進展性癌症病患認知預後的因素/ 陳貞秀劉莉妮徐翠霞蔣曉文雷靜怡唐秀治
原發性膽囊癌的臨床分析/ 陳志仁王蒼恩張文熊林錫泉白明忠李晉賢
A Case of Gastrointestinal Stromal Tumor (GIST) of Jejunum Presenting as Hollow Organ Perforation/ Shu-Hong ChuangHung-Bun LamChien-Liang Liu
A Disappearing Splenic Tumor on CT and MRI-A Case Report of Splenic Hamartoma/ Ming-Feng TsaiFei-Shih YangTsang-Pai LiuBe-Fong ChenTsang-En WangChien-Liang Liu
 
   
 
   

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