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1
題名:家族性甲狀腺癌    
Familial Thyroid Cancer
著者:鄭世平(Shih-Ping Cheng) ;楊圳隆(Tsen-Long Yang) ;鄭國祥(Kuo-Shyang Jeng) ;劉建良(Chien-Liang Liu) ;李居仁(Jie-Jen Lee) ;劉滄柏(Tsang-Pai Liu)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:癌症遺傳學 ; 基因篩檢 ; 多發性內分泌腫瘤 ; 多發性原發腫瘤 ; 甲狀腺癌 ; cancer genetics ; genetic screening ; multiple endocrine neoplasia ; multiple primary neoplasms ; thyroid cancer
刊名:中華民國癌症醫學會雜誌
頁碼:41-48
語言:繁體中文
摘要: 中文摘要PDF ; 英文摘要PDF

家族性甲狀腺癌包含源自甲狀腺濾泡細胞的「家族性甲狀腺非髓質癌」或濾泡旁細胞的「家族性甲狀腺髓質癌」(多發性內分泌腫瘤第二型)。家族性甲狀腺非髓質癌可以是多發性腫瘤症候群的一部分,也可以獨立發生,定義為兩位或以上一等親緣關係的病患被診斷出有源發自甲狀腺濾泡的癌症。家族性甲狀腺非髓質癌有較高機率的多發性、淋巴轉移及復發率,宜採取積極的治療。此外,甲狀腺非髓質癌病患的近親有較高得到甲狀腺癌的機會,應考慮接受定期檢查。甲狀腺髓質癌的病患,則應常規接受RET原致癌基因檢查,基因檢查有兩個目的:一是追蹤檢查患者本身其他多發性內分泌腫瘤第二型的併發症(嗜鉻細胞瘤和副甲狀腺機能亢進),二是家族篩檢方便早期發現其他的帶原者。基因篩檢若發現帶有突變的RET原致癌基因,多發性內分泌腫瘤2B型應於一歲之前接受預防性甲狀腺切除,其他則視突變位置的危險度於五到十歲之前接受甲狀腺切除手術。雖然基因篩檢有助於早期診斷或預防癌症,臨床醫師應注意基因篩檢對患者及其親屬心理、倫理層面的影響。
Familial thyroid cancer can arise from follicular cells (familial nonmedullary thyroid cancer, FNMTC) or from parafollicular cells (multiple endocrine neoplasia type Ⅱ, MEN2). Familial nonmedullary thyroid cancer occurs either as a discrete entity defined by the presence of thyroid cancers of follicular cell origin within two or more first-degree relatives or as part of other multitumor syndromes. FNMTC is associated with multifocality, aggressive behavior and frequent recurrences, and therefore should be treated aggressively. Family members are at an increased risk of developing thyroid cancer and need to be followed closely. For patients with medullary cancer, genetic testing for a RET mutation is necessary for timely detection of other MEN2 manifestations particularly pheochromocytomas and early identification of new family members who are gene carriers. Patients with MEN2B should undergo total thyroidectomy during infancy and prophylactic thyroidectomy should be performed in other gene carriers before 5 to 10 years of age. Clinicians must be aware of psychosocial and ethical issues related to patients with familial thyroid cancer and their family members.


    

本卷期目次
中華民國癌症醫學會雜誌
Treatment Outcome in Oropharyngeal Carcinoma-Preliminary Report/ Chih-Yung YangYi-Shing LeuJehn-Chuan LeeYi-Fang ChangMin-Jer HuangYu-Jen ChenHong-Wen ChenHung-Tao HsiaoChung-Ji Liu
Carcinoid Tumors of the Appendix-Experience in a Teaching Hospital/ Jiunn-Chang LinTsang-Pai LiuJee-Jen LeeChien-Liang LiuTsen-Long Yang
Transanal Local Excision of Rectal Malignant Neoplasms/ Wai-Hung LeungMing-Jen Chen
Local Anesthesia to Improve Postoperative Outcome for Breast Cancer Surgery: Preliminary Results/ Chung-Hsin TsaiYung-Wei HsuShih-Ping ChengChien-Liang LiuTsen-Long YangChun-Yueh LinYuan-Ching Chang
電腦刀立體定位放射性手術於治療第一型及第二型聽神經腫瘤之研究/ 林乾閔蔡若婷林牧熹林家瑋蘇鈺凱柯宗伯魏立邱文達張丞圭葉宜憲
家族性甲狀腺癌/ 鄭世平楊圳隆鄭國祥劉建良李居仁劉滄柏
影響臺灣地區非安寧照顧下進展性癌症病患認知預後的因素/ 陳貞秀劉莉妮徐翠霞蔣曉文雷靜怡唐秀治
原發性膽囊癌的臨床分析/ 陳志仁王蒼恩張文熊林錫泉白明忠李晉賢
A Case of Gastrointestinal Stromal Tumor (GIST) of Jejunum Presenting as Hollow Organ Perforation/ Shu-Hong ChuangHung-Bun LamChien-Liang Liu
A Disappearing Splenic Tumor on CT and MRI-A Case Report of Splenic Hamartoma/ Ming-Feng TsaiFei-Shih YangTsang-Pai LiuBe-Fong ChenTsang-En WangChien-Liang Liu
 
   
 
   

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