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項次 書目
1
題名:THERAPEUTIC EFFECT OF ARSENIC TRIOXIDE CONTAINING LOTION IN A HUMAN BLADDER CARCINOMA XENOGRAFT MODEL    
三氧化二砷外用劑對異體移植模式人類膀胱癌細胞的治療效果
著者:Yi-Fang Chang(張義芳) ;Yun-Long Tseng(曾雲龍) ;Ken-Hong Lim(林建鴻) ;Johnson Lin(林炯森) ;Yu-Fang Hu(胡宇芳) ;Yao-Kun Huang(黃耀坤) ;Ruey-Kuen Hsieh(謝瑞坤) ;Ming-Jer Huang(黃明哲)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:Arsenic trioxide (ATO) Cutaneous metastasis Solid tumor
刊名:Journal of the Chinese Oncology Society
頁碼:9-14
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

背景:轉移性癌症的病人大約有10%會產生皮膚轉移。這些皮膚性的轉移病變通常以局部放射線治療或化學藥物治療,但是治療的結果並不令人滿意。在本篇中,我們研究用接種人類膀胱癌細胞的老鼠,來評估三氧化二砷外擦劑對於轉移性皮膚病變的抗癌效果。 方法:用2 x 106個活HTB-9腫瘤細胞打入雌性BALB/c-Hfhllnu老鼠的左側脅腹皮下。在第19天,腫瘤約長到7-8mm時,隨機分成三組,每組6隻老鼠。第一組使用不含三氧化二砷的外擦劑當作控制組。第二組則對接種的皮下腫瘤製造一個人工傷口再塗含三氧化二砷的外用劑治療。第三組則直接在皮下腫瘤的皮膚上擦三氧化二砷的外用劑。三組的外用劑均一週使用三次,共持續八週。每次使用的外用劑為0.14gm(含0.0462 mg的三氧化二砷)。 結果:在治療35天後,第一組跟第二組之間以及第一組跟第三組之間腫瘤的生長有明顯的差別(P<0.05)。但是第二組跟第三組之間就沒有差別。這個研究顯示使用含三氧化二砷的外用劑,可以抑制皮下膀胱癌腫瘤的生長。 結論:在皮膚轉移病變的治療上,三氧化二砷的外用劑值的進一步的研究其使用之可行性。
BACKGROUND: Patients with metastatic carcinoma develop cutaneous metastases in about 10% of cases. These skin metastatic lesions are usually treated by radiation therapy and/or chemotherapy with disappointing results. In this study we used human bladder carcinoma xenograft nuice as a model to investigate whether arsenic trioxide lotion has an anti-tumor effect on skin metastases of human solid tumor cells. MATERIALS AND METHODS: Female BALB/c-Hfbllnu mice received subcutaneous injection to the left flanks on day 0 with 2 x 106 viable HTB-9 tumor cells. When the mean tumor size reached 7-8 mm at the 19th day, the mice were randomly divided into three groups of six mice. The first group was treated with the lotion containing no arsenic trioxide and served as the control group. The second group were given artificial wounds on tumors which were then treated with arsenic trioxide lotion. The third group was treated with the arsenic trioxide lotion on tumors. The treatment schedule was three times a week. The total dose of each treatment was 0.14 gm lotion (containing 0.0462 mg arsenic trioxide), which was applied to the skin over each visible tumor. RESULTS: There was a significant difference (P<0.05) in tumor growth between group 1 and group 2, and between group 1 and group 3 beginning from the 35th day after treatment, but there was no significant difference between group 2 and group 3. Arsenic trioxide lotion treatment delayed the growth of the subcutaneous bladder carcinoma regardless of whether the tumor was covered by skin or artificially wounded. CONCLUSION: The results of this study suggest that arsenic trioxide lotion is a worthy candidate for clinical trials.


    

本卷期目次
Journal of the Chinese Oncology Society
BONE MARROW NECROSIS AND MALIGNANCY: A SINGLE INSTITUTION EXPERIENCE/ Shyh-Jer LinHung-Bo WuMing-Sun YuHui-Hwa TsengYuk-Cheung Wang
THERAPEUTIC EFFECT OF ARSENIC TRIOXIDE CONTAINING LOTION IN A HUMAN BLADDER CARCINOMA XENOGRAFT MODEL/ Yi-Fang ChangYun-Long TsengKen-Hong LimJohnson LinYu-Fang HuYao-Kun HuangRuey-Kuen HsiehMing-Jer Huang
 
   
 
   

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