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1
題名:De novo CD5-positive Diffuse Large B-cell Lymphoma Presenting with Leg Edema    
以腳部水腫來表現之原發性CD5陽性濔漫性大B細胞淋巴瘤
著者:Huai-Hsuan Huang(黃懷萱) ;Chung-Wu Lin(林中梧) ;Sung-Hsin Kuo(郭頌鑫) ;Ann-Lii Cheng(鄭安理)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:濔漫性大B細胞淋巴瘤 ; CD5陽性 ; 莫須瘤 ; diffuse large B-cell lymphoma ; CD5-positive ; rituximab
刊名:Journal of Cancer Research and Practice
頁碼:120-128
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

背景:濔漫性大B細胞淋巴瘤(diffuse large B-cell lymphoma, DLBCL)是最常見的非何杰金氏淋巴瘤,且也是一個由多種疾病所組成的一群疾病。 案例描述:在此,我們報告一位罹患「原發性CD5陽性濔漫性大B細胞淋巴瘤」(de novo CD5-positive DLBCL)的病人,以右側骼骨附近、右側鼠蹊部附近、右側股骨附近、後腹腔、及食道附近之淋巴結腫大來表現。其初期臨床特徵是以五個月內逐漸惡化的右側大腿水腫為臨床表現。我們使用流式細胞儀,並合併組織病理學特殊染色來診斷原發性CD5陽性濔漫性大B細胞淋巴瘤。病人在接受三回合免疫化學治療(immunochemotherpay of rituximab plus CEOP)後達到完全緩解。然而,在完成六次免疫化學治療四個月後,病人疾病復發並以大量右側胸水表現。同時,我們針對原發性CD5陽性濔漫性大B細胞淋巴瘤的臨床表現及治療作文獻回顧和探討,並顯示它與其他濔漫性大B細胞淋巴瘤有著相當程度的差異,並針對此疾病發展一適合治療策略。 結語:總而言之,原發性CD5陽性濔漫性大B細胞淋巴瘤是一群相當特殊的淋巴瘤,且臨床病程較為侵犯性,預後較差。
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common of all non-Hodgkin's lymphomas, and is also a heterogeneous disease. Case Description: Here, we report a case of de novo CD5-positive DLBCL of the right iliac, right inguinal, and right femoral with retroperitoneal and peri-esophageal involvement who was diagnosed not only by flow cytometric immunophenotyping but also by immunohistochemistry analyses. Initially, the patient presented with a complaint of progressive right leg edema for 5 months. Although complete remission was achieved after three cycles of immunochemotherapy (rituximab plus CEOP), relapse with a massive right side pleural effusion developed four months later, after a total of six cycles of immunochemotherapy were administered. We also reviewed the clinical manifestations and treatments for the disease, and highlighted the importance of identifying de novo CD5-positive DLBCL from other DLBCL, and of developing proper treatment strategies for this subgroup of patients. Conclusions: In conclusion, de novo CD5-positive DLBCL is a distinct group of DLBCL with aggressive courses of disease progress, with typically worse prognosis than DLBCL.


    

本卷期目次
Journal of Cancer Research and Practice
Dual-time Point FDG PET-CT Imaging of Pulmonary Sclerosing Hemangioma Presenting as Solitary Pulmonary Nodule/ Pei-Ing LeeDong-Ling YouChia-Chuan LiuChih-Hsun ShihMing-Yuan LeeYu-Yi Huang
Surgical Management of Facial Nonmelanoma Skin Cancer/ Chien-Jen ChangShun-Yu HsiaoTing-Wei ChangYa-Ju HsiehNan-Lin WuYu-Hua LiKwok-Ming ChangPei-Wen HungYung-Fa Tsai
De novo CD5-positive Diffuse Large B-cell Lymphoma Presenting with Leg Edema/ Huai-Hsuan HuangChung-Wu LinSung-Hsin KuoAnn-Lii Cheng
Vincristine-Induced Polyneuropathy/ Guan-Min LaiCiyuan-Jheng WangChih-Yuan ChungShyuann-Yuh LinChin-Ye LinCheng-Shyong ChangMing-Ching ShenJen-Tsun Lin
Radiation-Induced Osteosarcoma of the Temporal Bone/ Yung-Hsin HsuShih-Ming JungWen-Cheng ChangYeng-Chung Chang
Unusual Case of Colitis Induced by Cytomegalovirus Reactivation after Autologous Peripheral Blood Stem Cell Transplantation in a Patient with Multiple Myeloma/ Shu-Yun HuangPing-Ying ChangCherng-Lih PerngWei-Chen HuangHsin-Chung LinYeu-Chin Chen
 
   
 
   

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