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項次 書目
1
題名:Study on Mechanical Properties of Thrombomodulin-transfected Cancer Cells by Atomic Force Microscopy     (14點)
著者:Chi-Chang LinTsung-I YinYi-Dong LinTung-I LinYing-Ting ChenJen-Fin LinHua-Lin WuHsien-Chang Chang
出版地區:台灣
出版城市:台南市
學科:醫學綜合
關鍵字:Atomic force microscopy (AFM) ; Thrombomodulin (TM) ; Mechanical properties of cell
刊名:Journal of Medical and Biological Engineering
卷期:30卷5期(2010.10)
頁碼:313-319
語言:英語
摘要: 英文摘要PDF

Thromb omodulin (TM) is a glycoprotei n dis tributed on cell membrane, which can alter the coagu lant activity of thrombin in terms of forming comple xes with thrombin. Recent studies have demonstrated novel functions of TM on regulating cell-t o-cell adhesion and cell morph ology of cancer cells. In this study, atomic force microscopy (AFM) was used to investigate the effect of TM on regulating cell morphology and mechanical propertie s in TM-negative human melanoma A2058 cells (vector cells) and another cell type which transfected with green fluorescent protein -tagged TM (TMG cells). The results showed the cellular morphology ofTMG cells having larger flattened fan-shaped lamellipod ia protru sion, lower height of the cell-cell junction and clearer stress fiber-like cytoskeleton compared with the vector cells, In addition, the Young 's modulu s of TMG cells (2646 ± 309 Pa) was higher than that of TM negative cells (1687 ± 235 Pa). These preliminary results demonstrate the TM glycoprotein possibly plays an important role to regulat e the cellular lamell ipodia protru sion, spreading and stiffness.


    

本卷期目次
Journal of Medical and Biological Engineering 30卷5期 (2010.10)
Review: Tissue Engineering Technology to Enhance Cell Recruitment for Regeneration Therapy/ Hiroshi KoharaYasuhiko Tabata
Parameter Investigation of Detrended Fluctuation Analysis for Short-term Human Heart Rate Variability/ Rong-Guan YehGau-Yang ChenJiann-Shing ShiehCheng-Deng Kuo
Development of a Multi-scale Noise Reduction Algorithm for Cone-beam Micro-CT Using Fuzzy Logic-based Anisotropic Filter/ Zhi-Wei TangGuang-Shu Hu
A High-capacity Reversible Data-hiding Scheme for Medical Images/ Shu-Chien HuangMing-Shun Lin
Multivariable Fuzzy Logic/Self-organizing for Anesthesia Control/ Yuan-Chao ChouMaysam F. AbbodJiann-Shing ShiehChia-Yu Hsu
Classification of Benign and Malignant Breast Tumors by Ultrasound B-scan and Nakagami-based Images/ Yin-Yin LiaoPo-Hsiang TsuiChih-Kuang Yeh
Study on Mechanical Properties of Thrombomodulin-transfected Cancer Cells by Atomic Force Microscopy/ Chi-Chang LinTsung-I YinYi-Dong LinTung-I LinYing-Ting ChenJen-Fin LinHua-Lin WuHsien-Chang Chang
Feasibility Study of Noninvasive Tumor Treatment with Focused Ultrasound/ Khaldon LweesyLuay FraiwanMais Al-ShalabiLayali MohammadRazan Al-Oglah
The Use of Virtual Reality-based Dynamometer Training to Enhance Selective Joint Torque Control in a Child with Cerebral Palsy/ Imre CikajloZlatko Matjačić
 
   
 
   

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