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1
題名:Quantitative Analysis of 11C-acetate in Nasopharyngeal Carcinoma with Positron Emission Tomography     (12點)
應用11C-acetate正子電腦斷層定量分析於鼻咽癌之診斷
著者:Yu-Hua Fang(方佑華) ;Tsair Kao(高材) ;Liang-Chih Wu(吳良治) ;Ren-Shyan Liu(劉仁賢)
出版地區:台灣
出版城市:台南市
學科:醫學綜合
關鍵字:11C醋酸鹽 ; 正子電腦斷層造影 ; 定量分析 ; 動態模型 ; 11C-acetate ; PET ; Quantitative analysis ; Kinetic model
刊名:Journal of Medical and Biological Engineering
卷期:23卷3期(2003.9)
頁碼:97-102
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

對11C-acetate正子電腦斷層影像定量分析來說,目前發展的幾個動態模型都是基於心臟造影提出。本研究旨在應用其中一個動態模型於腫瘤診斷,評估其可行性,並探討估算所得到的參數意義及臨床價值。十名病人,其中包含五名鼻咽癌病人及五名控制組病人,每位病人皆於鼻咽及肌肉各圈選一個ROI,並以非線性最小平方法估測動態模型中的四個參數,最後以這些參數計算11C-acetate攝取比例K值。我們發現在兩組病人間,鼻咽之K值有相當明顯的差異:在鼻咽癌病人平均為0.2675±0.1562,而控制組病人為0.0763±0.0425。此外,鼻咽癌病人的11C-acetate流入速率常數也高於控制組病人,但清除速率常數卻較低。在肌肉部分,兩組病人的速率常數並無明顯差異。這些結果顯示,使用定量分析可得到具生理意義的參數估測,而腫瘤的參數差異可用於腫瘤診斷,並可供臨床醫師作為客觀且定量的診斷依據。
Although several kinetic models have been proposed for myocardium 11C-acetate PET quantitative studies, currently there are no reports applying them to tumor diagnosis. In this study, we adopted one of the existing models for performing quantitative analysis on nasopharynx carcinoma (NPC) patients. Ten patients were included, with five NPC and five control subjects. For each subject, one ROI of nasopharynx area and one ROI of muscle area were drawn on PET images. Four rate constants were then estimated using the non-linear least squares method. The extraction fraction K was calculated from these estimated parameters. We found K showed significant difference in the two groups, while the average K of nasopharynx areas was 0.2675 ± 0.1562 in NPC and 0.0763 ± 0.0425 in control patients. In addition, a higher 11C-acetate inflow rate constant from plasma was observed in the NPC nasopharynx area, while the clearance rate was lower. Meanwhile, the rate constants of muscle area in the two groups showed no significant difference. These results indicate that, for tumors, those estimated parameters will be significantly different due to the characteristics of 11C-acetate uptake. In conclusion, our results proved the portability of applying kinetic model analysis in 11C-acetate tumor studies. Such an analysis can provide physicians with objective reference for clinical diagnosis.


    

本卷期目次
Journal of Medical and Biological Engineering 23卷3期 (2003.9)
Strain Compounding: Improvement in Contour Extraction of Ultrasonic Breast Imaging/ Wei-Ning LeePai-Chi Li
Structural and Functional Image Registration Using Maximum Mutual Information/ Hsiao-Ling HuangHong-Dun LinBeing-Tau ChungKang-Ping Lin
High Resolution Optical Doppler Tomography for in vivo Blood Flow Dynamics with Pharmacological Intervention/ Cheng-Jen ChangZhong-Ping Chen
Packaging Design for Implantable Microstimulator/ Chi-Chan HungCho-Liang ChungGin-Shu YoungKang-Ping LinJia-Jin Chen
A Web Services Based Brain Tumor Image Exchange System with Single Sign-On Access Management/ Ing-Yi ChenChao-Chi HuangHong-Dun LinKang-Ping Lin
Development of Internet Based Remote Health and Activity Monitoring Systems for the Elders/ Chung-hsien KuoFang-Ghun HuangKeng-Liang WangMing-Yih LeeHuai-Wen Chen
Degradation Behavior of Porous Calcium Phosphates/ Chien-Wen WangMin YanHsien-Chang ChangShinn-Jyh Ding
Quantitative Analysis of 11C-acetate in Nasopharyngeal Carcinoma with Positron Emission Tomography/ Yu-Hua FangTsair KaoLiang-Chih WuRen-Shyan Liu
 
   
 
   

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