原名「台灣學術線上」
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1
題名:Detecting the Process of Blood Coagulation and Clot Formation with High Frequency Ultrasound     (14點)
著者:Chih-Chung HuangPo-Hsiang TsuiShyh-Hau WangChun-Yi Chiu
出版地區:台灣
出版城市:台南市
學科:醫學綜合
關鍵字:Blood coagulation ; Clot formation ; High frequency ultrasound
刊名:Journal of Medical and Biological Engineering
卷期:25卷4期(2005.12)
頁碼:171-177
語言:英語
摘要: 英文摘要PDF

High frequency ultrasounds, up to 50 MHz, were applied to assess changes of blood properties during coagulating and clotting. Experiments were performed using calcium chloride solution to induce the blood coagulation (BC) and clot formation (CF) in porcine whole blood of various hematocrits ranged from 25 to 55%. The ultrasonic signals backscattered from the whole blood were digitized at a 500 MHz sampling frequency and collected for 30 minutes at one A-line per second temporal resolution. The corresponding M-mode images and integrated backscatters acquired from four transducers of different frequencies were processed to characterize blood properties. Two parameters, denoted as S(subscript r) and t(subscript c) respectively in response to the rate of change and duration between the onset of blood coagulation and the end of clot formation, were derived from the integrated backscatter as a function of time to further evaluate the sensitivity and accuracy for measurements. Results showed that backscattered signals acquired from different frequencies and their relative analysis may be applied to effectively detect the process of BC and CF. In particular, measurements using high frequency ultrasound tended to exhibits a better sensitivity to detect the coagulation, with larger average S(subscript r) and shorter t(subscript c) respectively corresponding to 0.23 dB/sec and 756 seconds measured from a hematocrit of 35% using a 50 MHz transducer. The discrepancy between results of t(subscript c) measured by different frequencies may be readily associated with the resultant size of the resolution cell of the transducer and the pulse duration. Both ultrasonic M-mode image and integrated backscatter in this study were validated to monitor the process of BC and CF and specifically with those quantitative parameters, S(subscript r) and t(subscript c). It enables a potential to further apply high frequency ultrasounds for early detecting BC and CF in clinical diagnoses.


    

本卷期目次
Journal of Medical and Biological Engineering 25卷4期 (2005.12)
Ultrasonic Image Enhanced by Shockwave-induced Cavitation/ Wen-Shiang ChenPing-Mo MaChih-Kuang Yeh
Ultrasound-Mediated Perfluorocarbon Microbubbles Bursting for Gene Transfection/ Yu-Hsiang LeeChun-Yen LaiPai-Chi LiChing-An Peng
Destruction Threshold Parameters Estimation for Ultrasonic Contrast Agents/ Chih-Kuang YehShin-Yuan SuWen-Shiang Chen
A Study on Microbubble-assisted Acoustic Cavitation/ Tzu-Yin WangKuan-Yu LaiChun-Yen LaiPai-Chi Li
Detecting the Process of Blood Coagulation and Clot Formation with High Frequency Ultrasound/ Chih-Chung HuangPo-Hsiang TsuiShyh-Hau WangChun-Yi Chiu
Synthetic Aperture Photoacoustic Imaging on Small Vessel Phantom Study/ Teng-Yuan LiuShu-Wei HuangHuihua Kenny Chiang
Cerebrovascular Response to Different Stimulations and Patterns in Healthy Volunteers/ Cheng-Yu YenLi-Ming LienJiann-Shing ShiehWei-Hung ChenHou-Chang Chiu
The Representations of Sonographic Image Texture for Breast Cancer Using Co-occurrence Matrix/ Shao-Jer ChenKuo-Sheng ChengYuan-Chang DaiYung-Nien SunYen-Ting ChenKu-Yaw ChangWen-Ching HsuTsai-Wang Chang
 
   
 
   

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