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項次 書目
1
題名:Monitoring Paraquat-induced Pulmonary Fibrosis in Rats with Micro-CT Finding and Histological Examination     (16點)
著者:Kai-Sung WangShih-Hsien ChangChi-Yuan LuChung-Hsin YehMing-Wei Lee
出版地區:台灣
出版城市:台南市
學科:醫學綜合
關鍵字:Micro-CT ; Paraquat ; Pulmonary fibrosis ; Histological sections ; 3D reconstruction
刊名:Journal of Medical and Biological Engineering
卷期:29卷6期(2009.12)
頁碼:312-319
語言:英語
摘要: 英文摘要PDF

The aim of this study is to monitor paraquat-induced pulmonary fibrosis in rats with micro-computed tomography (micro-CT) findings. Adult rats were divided into four groups and given a single oral dosage of aqueous solution of paraquat at 0 mg/kg, 40 mg/kg, 60 mg/kg, and 80 mg/kg, respectively. In the control group, the color and luster of the lung samples appeared normal and no petechia was observed. In the experimental groups, some petechia was observed in lung samples, and fibroblast and fibrinogen were found in histological sections, and the ground-glass predominance and reticulation in micro-CT findings increased during the period from the 1st week to the 3rd week, and decreased in the 4th week after the administration. In the experimental groups, the lung weight of adult rats increased when the dosage of paraquat was increased, but the body weight increments of adult rats decreased, therefore the ratios of lung weight over body weight increased with increased dosage, From the analysis of 3D micro-CT images, the results show that the effective capacity volume of the lungs gradually decreased with increased dosage, therefore micro-CT is seen as a powerful tool for fast diagnosis and longitudinal monitoring of pulmonary fibrosis.


    

本卷期目次
Journal of Medical and Biological Engineering 29卷6期 (2009.12)
Review: Synthesis of Fluorescent Metallic Nanoclusters toward Biomedical Application: Recent Progress and Present Challenges/ Cheng-An J. LinChih-Hsien LeeJyun-Tai HsiehHsueh-Hsiao WangJimmy K. LiJi-Lin ShenWen-Hsiung ChanHung-I YehWalter H. Chang
Influence of Collagen I Nanospheres on the Growth and Osteogenic Difference of Rat Bone Marrow Stromal Cells/ Kuo-Yu ChenChia-Mei ChungShyh-Ming KuoYueh-Sheng ChenChun-Hsu Yao
The Behavior of rhBMP2 Gene Transfecting Cells on Nanometer Hydroxyapatite/Chitosan Scaffold/ Wei-Bin SunKai-Ying SunChen-Lin ChuHai-Bo HuangFan Li
Effect of Vacuum Post-heat Treatment of Plasma-sprayed Hydroxyapatite Coatings on Their in vitro and in vivo Biological Responses/ Chyun-Yu YangChung-Wei YangLih-Ren ChenMing-Che WuTruan-Sheng LuiAndy KuoTzer-Min Lee
Guided Tissue Regeneration with Use of CaSO4-Chitosan Composite Membrane/ Shyh-Ming KuoGregory Cheng-Chie NiuCheng-Wen LanMin-Feng ChengMin-Yu ChiangShwu-Jen Chang
Monitoring Paraquat-induced Pulmonary Fibrosis in Rats with Micro-CT Finding and Histological Examination/ Kai-Sung WangShih-Hsien ChangChi-Yuan LuChung-Hsin YehMing-Wei Lee
Protein Adsorption and Cell Alignment on Micropatterned Phosphorylcholine Surfaces/ Yi-Chang ChungYi-Hong Chiu
The Morphometric Analysis of Maxillopalatal and Mandibular Changes of Skeletal Class Ⅲ Malocclusion Treated with Orthopedic Therapy/ Pao-Hsin LiuHong-Po Chang
 
   
 
   

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