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1
題名:Total Urinary Isothiocyanates, Glutathione S-Transferase M1 Genotypes, and Lung Cancer Risk: A Preliminary Nested Case-Control Study in Taiwan    
著者:Yu-Ching ChouMei-Hsuan WuCho-Chieh WuTsann YangChi-Ming ChuChing-Huang LaiChang-Yao HsiehSan-Lin YouChien-Jen ChenChien-An Sun
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:glutathione S-transferase M1 ; isothiocyanates ; lung cancer ; nested case-control study
刊名:Journal of Medical Sciences
卷期:25卷1期(2005.2)
頁碼:21-25
語言:英語
摘要: 英文摘要PDF

Background: This study was conducted as a preliminary examination of the relationship between urinary ITC levels and lung cancer risk, and the effect of polymorphisms in the GSTM1 gene on this ITC-associated risk. Methods: A nested case-control study using a urinary biomarker of total dietary intake of ITCs was performed. Thirty histologically confirmed lung cancer cases, ascertained by computerized linkage of data with information from the National Cancer Registry, were randomly selected from lung cancer cases in a 7-township cancer-screening cohort in Taiwan. Two cancer-free controls were matched to each case by age (±2 years), sex, residence, and date of collection of biologic specimens (±3 months). Total urinary ITC was measured by high-performance liquid chromatography, and homozygous deletion of the GSTM1 gene was determined by PCR. Results: The percentage of individuals with undetectable ITC in the urine was 20% for cases and 11.7% for controls. Individuals with detectable ITC had a 50% decreased lung cancer risk (adjusted OR=0.5, 95% CI=0.2-1.7). Furthermore, the decreased risk associated with detectable urinary ITC was restricted to individuals with a GSTM1-null genotype. Conclusions: ITCs appear to be associated with a non-statistically significant reduced lung cancer risk in this Chinese population in Taiwan. The GST metabolic genotype modified the protective effect of ITCs on lung cancer risk. Further studies are needed to confirm the findings from this exploratory study.


    

本卷期目次
Journal of Medical Sciences 25卷1期 (2005.2)
5α-Reductase Isozymes in the Prostate/ Yuan-Shan ZhuGuang-Huan Sun
The Anti-Apoptotic Protein Survivin Is Overexpressed in Patients with Primary Brain Lymphoma/ Junn-Liang ChangDai-Wei LiuLai-Fa SheuWei-Hwa Lee
Total Urinary Isothiocyanates, Glutathione S-Transferase M1 Genotypes, and Lung Cancer Risk: A Preliminary Nested Case-Control Study in Taiwan/ Yu-Ching ChouMei-Hsuan WuCho-Chieh WuTsann YangChi-Ming ChuChing-Huang LaiChang-Yao HsiehSan-Lin YouChien-Jen ChenChien-An Sun
Prevalence and Related Factors of Needle-Sharing Behavior among Female Prisoners/ Tony Szu-Hsien Lee
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Sertraline Treatment Caused Elevated Plasma Prolactin Concentrations in a Transsexual Patient with Major Depression/ Tzong-Shi WangYuan-Hwa Chou
Surgery for Cor Triatriatum in a Patient Preparing for Kidney Transplantation/ Chung-Yi LeeHou-Sheng YangChih-Yuan LinYi-Ting TsaiGou-Jieng HongChien-Sung Tsai
Transient Paraplegia and Paresthesia Caused by Type B Aortic Dissection/ Ying-Sheng ShenWen-Jinn LiawHung-Yi KuoMing-Ying LiuLi-Way Chang
Conservative Management of Traumatic Occlusion of a Renal Artery/ Chih-Hsien LeeLi-Way ChangDah-Shyong YuHsaio-Dung LiuHung-Chun ChungMing-Ying LiuDar-Shih Hsieh
 
   
 
   

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