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1
題名:Epidemiological Correlates of Impaired Liver Function in Taiwan, an Area Endemic for Chronic Liver Disease    
著者:Shu-Ting LuoYu-Ching ChouMei-Hsuan WuTsan YangChi-Ming ChuChing-Huang LaiChang-Yao HsiehSan-Lin YouChien-Jen ChenChien-An Sun
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:hepatitis B virus ; hepatitis C virus ; impaired liver function
刊名:Journal of Medical Sciences
卷期:25卷2期(2005.4)
頁碼:71-76
語言:英語
摘要: 英文摘要PDF

Background: To determine the prevalence and etiology of impaired liver function among Taiwanese. Methods: A cross-sectional study was carried out in 7 townships for 11,251 men aged 30-64 years. Blood specimens were tested for serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and for the presence of hepatitis B surface antigen (HBsAg) and antibodies to hepatitis C virus (anti-HCV). In addition, hepatitis B e antigen (HBeAg) was tested for the HBsAg-positive individuals. Histories of alcohol consumption and cigarette smoking were collected from participants using in-person questionnaires. Univariate analysis and multiple logistic regression analysis were conducted to determine the epidemiological correlates for impaired liver function, as defined by a combination of an ALT level of ≧45 IU/L and an AST level of ≧40 IU/L. Results: The prevalence of impaired liver function was 2.6% (95% confidence interval [CI], 2.3%-2.9%). Multiple logistic regression analysis showed that acquisition of HCV infection (adjusted odds ratio [OR], 13.5; 95% CI, 9.8-18.6) and active replication of HBV in HBsAg carriers (OR, 10.7; 95% CI, 7.3-15.7) were the predominant factors for an increased risk of impaired liver function. There was a significant additive interaction between HCV infection and a history of alcohol intake and cigarette smoking, for the risk of impaired liver function. Conclusions: Hepatitis C and hepatitis B virus infections were the dominant factors that signaled the risk of liver injury. In addition, the presence of HCV showed an additive synergistic effect for alcohol- and smoking-related impaired liver function among these Taiwanese.


    

本卷期目次
Journal of Medical Sciences 25卷2期 (2005.4)
Bipolar Disorder Induced by Resuming Interferon-Alpha Treatment in a Patient with Chronic Hepatitis B/ Chuan-Chia ChangI-Shin ShiahChih-Lun ChenYou-Chen Chao
Amplatzer Septal Occluder-Induced Arrhythmias/ Tsyr-Yuh HoMing-Chih TsaiPi-Chang LeeJen-Her LuChi-Ming LiangChung-Chang Laura MengBetau Hwang
Implantation of rhBMP-2 for Alveolar Augmentation and Oral Implants Osseointegration: Experimental Observations and Clinical Implications/ Ulf ME WikesjoGiuseppe Polimeni
Epidemiological Correlates of Impaired Liver Function in Taiwan, an Area Endemic for Chronic Liver Disease/ Shu-Ting LuoYu-Ching ChouMei-Hsuan WuTsan YangChi-Ming ChuChing-Huang LaiChang-Yao HsiehSan-Lin YouChien-Jen ChenChien-An Sun
Supersensitivity of Brachial Artery Endothelium-Independent Vasodilatation Reverses to a Normal Response to Flunarizine in Subjects with Migraine/ Jiunn-Tay LeeGiia-Sheun PengChang-Hung HsuChun-An ChengJiann-Chyun LinYaw-Don HsuJin-Ding LinJiu-Haw Yin
Occult Lung Cancer Masquerading as an Esophageal Submucosal Tumor/ Xian-Yuan GuoYeung-Leung ChengHsian-He HsuShih-Chun Lee
Successful Aggressive Treatment of Isolated Intraabdominal Metastases from a Thymic Carcinoma 16 Years after Surgery and Radiotherapy/ Hon-Yi LinYee-Min JenChung-Bao Hsieh
Chylous Ascites Caused by Right Hemicolectomy with Retroperitoneal Dissection along the Superior Mesenteric Artery/ Jung-Cheng KangShu-Wen Jao
Unilateral Optic Nerve Leukemic Infiltration with Sudden Vision Loss Heralding a Systemic Relapse of Acute Lymphoblastic Leukemia/ Hsuen-Fu LinMing-Shen DaiWoei-Yau KaoTsu-Yi Chao
 
   
 
   

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