原名「台灣學術線上」
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項次 書目
1
題名:Comparative Study of Preoperative Chemoradiation for Surgical Treatment of Esophageal Cancer     (14點)
術前化學放射治療應用於食道癌手術之成效--歷史上之比較
著者:Yung-Chie Lee(李元麒) ;Chen-Th Wu(吳振都) ;Pei-Ming Huang(黃培銘) ;Hsao-Hsun Hsu(徐紹勛) ;Yih-Leong Chang(張逸良)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:esophageal cancer ; preoperative chemoradiation ; surgery
刊名:Formosan journal of surgery
卷期:37卷1期(2004.2)
頁碼:1-7
語言:英語
摘要: 英文摘要PDF

Background and purpose: The result of surgical resection alone for patients with locally advanced esophageal cancer had been unsatisfactory before in our hospital. A treatment protocol was started in 1995 to test the effect of preoperative concurrent chemoradiation (CCRT) followed by surgery on patient survival, compared with surgery alone. Methods: Patients with locally advanced esophageal carcinoma (2T2 or Nt) received preoperative concurrent CCRT, which included daily cisplatin (6 mglm2/day) plus flurouracil (5-Fu) (225 mglm2/day) with concurrent radiation at a daily fraction dosage of 200 cGy, 5 days per week, for a total dose of 3,600 cGy. Surgical resection was performed 3 to 4 weeks after CCRT. Results: During the period from January 1987 through December 1999, a total of 169 patients with esophageal carcinoma were treated in our department. Sixtyseven patients had received complete course of preoperative CCRT. After CCRT, tumor response rate was 55.3% (partial response, 29.9% and complete response, 25.4 %). After surgery, the in-hospital operative mortality was 20.9 % in CCRT plus surgery group, which was slightly higher than surgery alone group (13.7 %), but the difference was statistically insignificant. CCRT plus surgery group had a beUer 5- year survival rate (52.3%) than surgery alone group (19.5%). In this series, tumor size, pathological stage, status of lymph node metastasis and tumor response to CCRT are significant prognostic factors. Conclusions: Utilization of preoperative CCRT followed by surgical resection for locally advanced esophageal cancer provides a beUer patient survival compared with surgery alone.




本卷期目次
Formosan journal of surgery 37卷1期 (2004.2)
Comparative Study of Preoperative Chemoradiation for Surgical Treatment of Esophageal Cancer/ Yung-Chie LeeChen-Th WuPei-Ming HuangHsao-Hsun HsuYih-Leong Chang
Saccharomyces Cerevisiae Causing Multiple Perforation of the Ascending Colon/ Hao-Ming ChangGuan-Yeu DiauHong-Ming ChaoChin-Chun Chu
Laparoscopic Cholecystectomy in Situs Inversus Totalis--A Case Report and Review of the Literature/ Yih-Huei UenChen-Yi KuoYi Chen
Dialysis-Related Amyloidosis with Involvement of Hip and Shoulder Joints--A Report of Two Cases/ Chung-Da WuChi-Chen HouMing-Yang KoeChing-Cherng Tzeng
Drop Foot Induced by Intraspinal Paraganglioma--Case Report/ Chih-Ju ChangJing-Shan HuangShih-Hung HuangYung-Chien Huang
Primary Intraosseous Meningioma--A Case Report/ Jiao-Chiao YangJing-Shan Huang
Mediastinal Cystic Lymphangioma Complicated with Post Operative Chylothorax--A Case Report/ I-Lin HsuYaou FongChang-Chuan Su
Reduction of Superficial Thermal Injury Using Cryogen Spray Cooling in Conjunction with Nd--YAG Laser for Cartilage Reshaping of Composite Cartilage Flaps--Preliminary Investigation/ Cheng-Jen ChangKwok-Leung TsangLynn-Lee ChiuBJF Wong
 
   
 
   

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