原名「台灣學術線上」
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1
題名:The presence of TP53 and dedifferentiation of low-grade glioma: A rare possible adverse effect of radiotherapy?     (8點)
著者:Yi-Chieh HungHuai-Che YangShih-Chieh LinWen-You GuoWen-Yuh ChungKang-Du Liu
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:low-grade glioma ; malignant transformation ; radiotherapy ; secondary glioblastoma ; TP53
刊名:Formosan journal of surgery
卷期:46卷1期(2013.2)
頁碼:19-22
語言:英語
摘要: 英文摘要PDF

Radiotherapy and radiosurgery are important modes of treatment for benign and malignant brain tumors. Radiation-induced tumors and radiation-induced malignant transformation of tumors have been described in many reports. Radiotherapy is one of the standard treatments for intracranial glial tumors. However, there is limited discussion of radiation carcinogenesis in glioma treatment. We present a 58-year-old male who was initially diagnosed to have low-grade glioma in an eloquent area of the brain by stereotactic biopsy. The tumor progressed rapidly after radiotherapy and a second stereotactic biopsy was done. Based on the WHO classification, the diagnosis for the second specimen was high-grade glioma. Histopathology showed that the expression of TP53 had increased from 40% to 60% in the second specimen. The finding was consistent with other reports of the malignant transformation of benign tumor after radiotherapy. Radiation carcinogenesis may be one of the causes for tumor progression to high-grade within 6 months. The effect of radiotherapy on the control of glioma is well-documented. Radiation carcinogenesis, which could cause malignant transformation of benign brain tumors, could also be observed in low-grade glioma. This report clearly indicates that caution is warranted regarding the use of radiotherapy for glial tumors, especially for low-grade gliomas.


    

本卷期目次
Formosan journal of surgery 46卷1期 (2013.2)
Sex different responses and immunomodulation in severe sepsis/ Tsann-Long Hwang
Chronic subdural hematoma in patients under age 65 years: A comparative study of age cohort/ Wei-Lun LoTao-Chen LeePeng-Shiang FangYu-Hua Huang
Pituitary apoplexy associated with an inverted papilloma of sphenoid sinus/ Sang-Jek LiewJung-Tung LiuChao-Yu ShenWei-Chean Tan
The presence of TP53 and dedifferentiation of low-grade glioma: A rare possible adverse effect of radiotherapy?/ Yi-Chieh HungHuai-Che YangShih-Chieh LinWen-You GuoWen-Yuh ChungKang-Du Liu
Bleeding gastrointestinal stromal tumor in a patient with a history of leiomyoma of the ileum/ Wei-Chen LinChen-Wang ChangChing-Wei ChangChung-Hsin TsaiHorng-Yuan Wang
Ileo-ileal intussusception secondary to inflammatory fibroid polyp with initial presentation of bloody stool/ Li-Chun KaoChe-Jen HuangChun-Chieh WuChih-Bin ChienFeng-Shu ChangJan-Sing Hsieh
Giant cell tumor of the temporal bone/ Shih-Wei HsuDueng-Yuan HuengHsin-Chung LinMing-Ying LiuHsin-I MaChung-Ching Hsia
Appendiceal diverticular disease/ T.-B. Chao
Appendiceal diverticular disease/ Yun-Wu DengHsiao-Bai YangKuei-Chen FengTzu-Hui LeiChih-Ping Lee
 
   
 
   

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