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題名:Photodynamic Diagnosis Using PhotofrinR for Induced Malignant Oral Lesions in an Animal Model     (20點)
使用PhotofrinR光動力診斷於引發性口腔癌之動物模型
著者:Muh-Shi Lin(林牧熹) ;Sally M H Cheng(鄭名琁) ;Pei-Shu Hwang(黃培書) ;Cheng-Jen Chang(張承仁)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:PhotofrinR ; photodynamic diagnosis ; oral neoplasms ; hamster
刊名:Formosan journal of surgery
卷期:39卷1期(2006.2)
頁碼:9-18
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

治療之口腔癌病人之癒後與改善和早期診斷之結果有關。而切除範圍之標定亦關係著切除手術之結果與重建手術之難易。因此,本研究主要的目的即是在評估光顯劑PhotofrinR用於診斷早期口腔癌及病變之動物模型。期待藉此結果能推展於人類口腔病變之臨床診斷。於14隻倉鼠兩側口腔內膜用0.5%致癌劑(DMBA)擦拭一天二次持續二週,以造成引發性口腔黏膜病變。以2.5 mg/kg PhotofrinR靜脈注射於各個口腔黏膜病變之倉鼠。約三小時後用波長380至420奈米之藍光照射而使之顯現螢光,並切片處理以為病理檢查之對照。定量之分析則以比較正常與病變組織螢光顯影於紅藍綠及黑灰對比之影像處理系統,並以變異數分析法(ANOVA)為多方之統計分析。在28個倉鼠口腔黏膜病變的切片組織中,4(14%)為鱗狀上皮增生(1例為輕微,3例為嚴重)及24(86%)鱗狀上皮細胞癌。其靈敏度在肉眼下觀察合併紅藍綠及黑灰對比之影像處理為92%,在顯微觀察下經合併紅藍綠及黑灰對比之影像處理則為94%。其專一性在肉眼觀察下為95%,在顯微觀察下則為97%。結果顯示,正常組織與病變組織之分別在統計學上有明顯的差異性。因此,吾人認為光誘發螢光以偵測PhotofrinR於動物模型口腔內病變是一種可行之方法。藉此可診斷早期口腔病變及口腔癌。
Objective: The prognosis of patients suffering from oral cancer can be improved by early diagnosis. Exact demarcation of tumor margins could contribute to optimal results in surgical excision and reconstruction. Therefore, this study evaluates PhotofrinR with protoporphyrin IX (PPXI) fluorescence as a new diagnostic procedure for the detection of oral neoplasms in animal models. The aim of this study is to assess these parameters, which can be extended to clinical applications for human oral neoplasms. Methods: Fourteen male Golden Syrian hamsters were included in this study. 0.5% D.M.B.A (9,10 dimethyl1-1, 2-benzanethracene), was brushed onto the cheek pouches bilaterally daily for 2 weeks. Hamsters with oral neoplasms received 2.5 mg/kg PhotofrinR intravenously. After a period of 3 hours, the neoplasms underwent fluorescence illumination (λ ex = 380-420 nm). A quantitative analysis of the fluorescence contrast between the neoplastic and surrounding tissues was performed using the RGB Mode (Red, Green, Blue) and the GS (Gray Scale). Statistical analysis was performed by means of ANOVA test for multiple comparisons. Results: Analysis of the 14 hamsters' 28 biopsies revealed that 4 (14%) displayed squamous hyperplasia (1 mild, 3 severe) and 24 (86%) displayed squamous cell carcinoma. The sensitivity of neoplastic tissue evaluated using the RGB and GS modes combined reached 92% in the macroscopic study, and 93% in the microscopic study. The specificity of neoplastic tissue evaluated using the RGB and GS modes combined reached 95% in the macroscopic study, and 97% in the microscopic study. The difference between healthy tissue and the lesions as a group is statistically significant. Conclusions: Light-induced fluorescence detection using PhotofrinR provides a sensitive technique for the early identification of malignant neoplasms in the oral cavity of our animal models.


    

本卷期目次
Formosan journal of surgery 39卷1期 (2006.2)
Intraoperative Intracranial Pressure Monitoring for Early Detection of Delayed Intracranial Hematoma: A Report of 3 Cases/ Tsung-Chih YehJinn-Rung KuoChung-Ching Chio
Spontaneous Rupture of the Kidney due to Genitourinary Tuberculosis/ Yen-Chieh WangYung-Chiong ChowWen-Chou LinStone Yang
Rectal Ameboma Associated with Amebic Liver Abscess Mimicking Rectal Carcinoma with Liver Metastasis: Report of a Case/ Hsin-Yuan LinYang-Guo FanDien-Wei Wang
Idiopathic Thoracic Duct Stenosis Causing Chylopericardium: Report of a Case/ Li-Ming HsuPo-Chih Cheng
Caval Inflow Occlusion during Surgery for Tricuspid Infective Endocarditis: Report of a Case/ Kuan-Ming ChiuJer-Shen ChengTzu-Yu LinShu-Hsun ChuShao-jung Li
Magnolol Modifies the Cytokine Response after Sublethal Hemorrhage/ Hsin-Chin ShihJackson Jerkan WuMu-Shun HuangChun-I HuangChen-Hsen Lee
Photodynamic Diagnosis Using Photofrin(superscript ®) for Induced Malignant Oral Lesions in an Animal Model/ Muh-Shi LinSally M H ChengPei-Shu HwangCheng-Jen Chang
Fistula between Esophagust Subclavian Artery Caused by Foreign Body Penetration: Report of a Case/ Jia-Ming ChangYueh-Feng TsaiMing-Ho WuYau-Lin TsengWu-Wei LaiMu-Yen LinI-Ling Hsu
Tension Pneumocephalus: Report of Two Cases/ Te-Cheng YuehKuang-Chen HungDyi-Sheng Chang
Magnolol Modifies the Cytokine Response after Sublethal Hemorrhage/ Hsin-Chin ShihJackson Jerkan WuMu-Shun HuangChun-I HuangChen-Hsen Lee
Fistula between Esophagust Subclavian Artery Caused by Foreign Body Penetration: Report of a Case/ Jia-Ming ChangYueh-Feng TsaiMing-Ho WuYau-Lin TsengWu-Wei LaiMu-Yen LinI-Ling Hsu
Spontaneous Rupture of the Kidney due to Genitourinary Tuberculosis/ Yen-Chieh WangYung-Chiong ChowWen-Chou LinStone Yang
Intraoperative Intracranial Pressure Monitoring for Early Detection of Delayed Intracranial Hematoma: A Report of 3 Cases/ Tsung-Chih YehJinn-Rung KuoChung-Ching Chio
Caval Inflow Occlusion during Surgery for Tricuspid Infective Endocarditis: Report of a Case/ Kuan-Ming ChiuJer-Shen ChengTzu-Yu LinShu-Hsun ChuShao-Jung Li
Tension Pneumocephalus: Report of Two Cases/ Te-Cheng YuehKuang-Chen HungDyi-Sheng Chang
Idiopathic Thoracic Duct Stenosis Causing Chylopericardium: Report of a Case/ Li-Ming HsuPo-Chih Cheng
Rectal Ameboma Associated with Amebic Liver Abscess Mimicking Rectal Carcinoma with Liver Metastasis: Report of a Case/ Hsin-Yuan LinYang-Guo FanDien-Wei Wang
Photodynamic Diagnosis Using PhotofrinR for Induced Malignant Oral Lesions in an Animal Model/ Muh-Shi LinSally M H ChengPei-Shu HwangCheng-Jen Chang
 
   
 
   

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