原名「台灣學術線上」
包含TAO期刊庫 + TAO書籍庫 + 論文 + 史料文獻
首頁 | 關於TAO | 瀏覽 | 進階查詢 | 參考工具 | 會員服務 | 已購專書 | RSS服務 | 電子報 | FAQ  
查詢範圍:
   
查詢模式:
熱門查詢詞:
dvd臺灣中國荷爾蒙
   
   
   
     
   
 
項次 書目
1
題名:Pathophysiological Factors Contributing to Keloid Formation     (12點)
蟹足腫形成之病理生理因子
著者:Fa-Lai Yeh(葉發來)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:keloid ; pathophysiology
刊名:Formosan journal of surgery
卷期:43卷1期(2010.2)
頁碼:1-6
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

正常之傷口癒合會導致蟹足腫。目前蟹足腫的治療對醫師們而言,仍是相當困難且具挑戰性。若我們能對這種疾病之成因有更完整的了解,將有助於成功治療方式之開發。本文乃綜述目前我們對蟹足腫成因之了解。文獻上以及我們的研究結果顯示,與來自正常組織的纖維母細胞相比,蟹足腫纖維母細胞呈現較強的生長潛力,以及可以產生較多量的膠原蛋白。此外,我們的研究結果亦顯示,與正常的纖維母細胞相比,蟹足腫纖維母細胞產生較少量的、能參與以及調控發炎反應的物質,包括MCP-1、PGE2、MMP-1、MMP-2以及TIMP-2。近來的文獻也顯示,蟹足腫的組織產生過量的TGF-β,且TGF-β的產生調控也不正常。以上這些在傷口癒合程序中所發生的改變,可能導致延遲的、延續的發炎反應,以及皮膚傷口膠原蛋白的堆積,而形成難纏的蟹足腫。
Keloid formation occurs following an abnormal wound healing. It represents a significant therapeutic challenge to physicians. A better understanding of the pathophysiologic processes underlying keloid formation may help in the development of more successful therapeutic interventions. This article delineates current information on the pathogenesis of keloids. Results reported in the literature and obtained from our studies showed that keloid-derived fibroblasts demonstrated a higher growth potential and produced higher levels of procollagen than those produced by control-derived fibroblasts. In addition, our results also showed a decreased production of inflammatory mediators of MCP-1, PGE2, MMP-1, MMP-2 and TIMP-2 by keloid-derived fibroblasts as compared with normal skin-derived fibroblasts. Furthermore, current literature also indicates that the growth factor TGF-s is overproduced and poorly regulated in keloid tissue. These alterations in the wound healing process may result in delayed and prolonged activation of injury-induced inflammation as well as imbalance in the extracellular matrix formation and degradation that may contribute to excess deposition of collagen in skin lesions and lead to keloid formation.




本卷期目次
Formosan journal of surgery 43卷1期 (2010.2)
Pathophysiological Factors Contributing to Keloid Formation/ Fa-Lai Yeh
Results of Unstable Peritrochanteric Fractures Treated with Dynamic Hip Screws (DHS) Fixation with or without Trochanter Stabilizing Plate (TSP) Augmentation/ Chun-Wei YewChun-Yu ChangPo-Wen Shen
Dexamethasone Combined with Morphine does not Decrease Postoperative Nausea and Vomiting in Patients Undergoing Thyroidectomy or Parathyroidectomy/ Jong-Yueh LinFong-Fu ChouTing-Lung LinKun-Chou HsiehYa-Ling Yang
Malignant Extrarenal Rhabdoid Tumors of the Omentum with Hemoperitoneum: Report of a Case/ Hui-Han LinShih-Chi WuRay-Jade ChenYu-Chiang Lin
Stab Wound in the Neck with Injury to the Cervical Cord and Ipsilateral Vertebral Artery: Report of a Case/ Da-Wei HuangKuo-Cheng HuangVong-Kuoy PhuongShih-Hahn Chen
Umbilical Metastasis-An Unusual Presentation of Colon Cancer: Report of two Cases and Review of Literature/ Ting-Min HsiehCheuk-Kwan SunHong-Hwa Chen
Primary Intraventricular Hemorrhage due to Rupture of Angiographically Occult Vascular Malformation: Report of a Case/ Yu-Kai ChengMing-Shian LuJen-Tsung YangMing-Hsueh LeeChen-Hsing SuTing-Chung Wang
First-line Therapy with Lapatinib (TykerbR) in Metastatic Breast Cancer that Progressed on Adjuvant Trastuzumab (HerceptinR) Treatment: Report of a Case/ Ya-Fen HsuFiona Tsui-Fen ChengYen-Kung ChenChin-Chu Wu
Arterial Switch Operation for Transposition of the Great Arteries/ Ing-Sh Chiu
 
   
 
   

與TAO合作 | 隱私與版權聲明 | 聯絡方式 | 下載Adobe Reader
地址:台北市中正區(100)北平東路30-12號3樓
電話:(02)2393-6968 傳真:(02)2393-6877
Email: service@wordpedia.com
Wordpedia Family: 學校、企業版入口 | 遠流影音館
Copyright©2011 Wordpedia Co., Ltd. All Rights Reserved.