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1
題名:ANTI-CD 20 ANTIBODY AS INITIAL TREATMENT FOR PRIMARY CONJUNCTIVAL MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA     (14點)
抗CD 20單株抗體做為結膜原發性黏膜相關淋巴組織淋巴瘤之初步治療
著者:Chang-Lin Chen(陳昶齡) ;Sheng-Fung Lin(林勝豐) ;Cheng-Hsien Chang(張丞賢) ;Ya-Chi Chen(陳雅琪)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:anti-CD20 monoclonal antibody ; rituximab ; conjunctiva ; mucosa-associated lymphoid tissue lymphoma
刊名:中華民國眼科醫學會雜誌
卷期:50卷2期(2011.12)
頁碼:296-302
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:報告一病例以anti-CD20單株抗體治療結膜原發性MALT淋巴瘤之成效。 方法:病例報告。 結果:這位53歲的女性病人患有雙側結膜MALT淋巴瘤第IVA期,病人接受anti-CD20單株抗體(Rituximab)治療,在完成了第五次的Rituximab注射療程後,左眼的淋巴瘤完全消失,而右眼的淋巴瘤縮小但未完全消失,之後雙眼的淋巴瘤在追蹤期間內一直維持穩定,Rituximab注射並未引起全身性的副作用。診斷後29個月由於懷疑骨髓細胞異常,病人接受化學治療CEOP(Endoxan、Epirubicin、Vincristine和prednisolone)合併Rituximab。但因肝功能異常未完成治療而終止。診斷後73月右結膜病理檢查顯示無腫瘤細胞。 結論:單獨使用Anti-CD 20 antibody來治療結膜MALT lymphoma可達到初期縮減腫瘤效果,且無全身性副作用。
Purpose: Investigation of Anti-CD20 monoclonal antibody as an initial and single regiment to treat conjunctival mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) Methods: Case report. Results: A 53-y/o female patient with bilateral conjunctival MALT lymphoma in stage IV A (bone marrow aspiration showing increased lymphocytes) was treated with anti-CD20 monoclonal antibody (Rituximab 530mg per dose for 9 times). After the fifth injection of Rituximab, the lymphoma of the left eye achieved complete remission and remained stable. The lymphoma of the right eye reduced in size but the residual tumor persisted. No side effect was noted during the course of anti-CD20 antibody treatment. Twenty-nine months after diagnosis, she received an incomplete course of chemotherapy: CEOP (Endoxan, Epirubicin, Vincristine and prednisolone) in combination of rituximab due to suspected bone marrow involvement. The treatment ceased due to abnormal liver function. At 73 months after diagnosis, the right conjunctival biopsy revealed negative tumor cells. Conclusion: Anti-CD20 alone exhibits a marked effect of treating primary conjunctival MALT lymphoma without systemic side effect.


    

本卷期目次
中華民國眼科醫學會雜誌 50卷2期 (2011.12)
淚囊鼻淚管疾病/ 林素玲
隔膜前蜂窩性組織炎及眼窩蜂窩性組織炎/ 畢勇賢謝嫣文
甲狀腺眼病變的內科治療/ 陳雅琪張丞賢
甲狀腺突眼治療新觀念/ 廖述朗
成人淚囊炎之致病菌與藥物敏感性/ 朱書緯張丞賢
抗血管內皮生長因子於青光眼手術之運用/ 吳秀琛
ADVANCED SURGERY AND OCULAR SURFACE RECONSTRUCTION FOR CORNEAL INJURY/ Lung-Kun YehYeong-Fong ChenDavid HK Ma
TOMOGRAPHIC CHANGES IN DIABETIC MACULAR EDEMA MANAGED BY INTRAVITREAL BEVACIZUMAB WITH OR WITHOUT POSTERIOR SUBTENON INJECTION OF TRIAMCINOLONE/ Jia-Kang Wang
SHORT-TERM RESPONSE OF DIABETIC MACULAR EDEMA TO INTRAVITREAL BEVACIZUMAB: AN OPTICAL COHERENCE TOMOGRAPHIC PATTERNS ANALYSIS/ Jia-Kang Wang
AHMED VALVE IMPLANTATION IN THE CILIARY SULCUS IN A PATIENT WHO HAD PREVIOUSLY UNDERGONE PENETRATING KERATOPLASTY/ Shu-I PaoDa-Wen LuMing-Cheng TaiYi-Hao ChenKe-Hung Chien
ANTI-CD 20 ANTIBODY AS INITIAL TREATMENT FOR PRIMARY CONJUNCTIVAL MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA/ Chang-Lin ChenSheng-Fung LinCheng-Hsien ChangYa-Chi Chen
ACUTE VISION LOSS AS THE INITIAL PRESENTING FEATURE OF ACUTE MYELOID LEUKEMIA IN A YOUNG MAN/ Meng-Wei HsiehKe-Hung ChienYun-Hsiang ChangJiann-Torng ChenDa-Wen Lu
TRAN-SCLERAL FIXED INTRAOCULAR LENS DISLOCATION PRESUMABLY CAUSED BY A ROLLER-COASTER RIDE/ Pei-Tzu KuanHung-Yu LinShih-Chun Chao
CLINICAL AND CONFOCAL MICROSCOPY FINDINGS OF FUNGAL KERATITIS CAUSED BY ZYGOMYCOTA: A CASE REPORT/ Wen-Hong HoMing-Cheng TaiJiann-Torng Chen
WOUND INFECTION BY MYCOBACTERIUM FORTUITUM AFTER CLEAR-CORNEA CATARACT SURGERY--A CASE REPORT/ Li-Ying ChienHui-Chuan ZhengZong-Xue LiuWei-Chun Chan
STAPHYLOCOCCUS AUREUS INFECTIOUS SCLERITIS WITH UNKNOWN CAUSE: A CASE REPORT/ Chih-Chien HsuPei-Yu LinYu-Mei ChangShui-Mei Lee
ATYPICAL CASE OF TRICHILEMMAL CARCINOMA OF THE EYELID/ Ying-Hsuen WuChun-Chi ChiangYi-Yu Tsai
DENSE CORNEAL BLOOD STAINING AND ITS HISTOPATHOLOGICAL CHARACTERISTICS--A CASE REPORT/ Yi-Chieh PoonMing-Tse KuoHun-Ju YuPo-Chiung Fang
ACUTE ANGLE-CLOSURE ATTACK ASSOCIATED WITH TRAVOPROST INDUCED UVEAL EFFUSION IN A NANOPHTHALMIC EYE--A CASE REPORT/ Yu-Hsuan HuangTing-Yu WuTsing-Hong WangJehn-Yu Huang
偏頭痛患者使用Topiramate引起兩眼急性隅角閉鎖型青光眼及急性近視性變化-病例報告/ 林志忠曾柏宸陳純貞翁林仲劉秀雯
INTRAVITREAL BEVACIZUMAB (AVASTIN) INJECTION-INDUCED RAPID RESOLUTION OF SEVERE HYPERTENSIVE RETINOPATHY IN A PATIENT WITH CHRONIC RENAL DISEASE: A CASE REPORT/ Ren-Wen HoChih-Hsin Chen
CAVITARY CHANGES IN RETINOBLASTOMA AFTER CHEMOTHERAPY--A CASE REPORT/ Chang-Yu LuLing-Yuh Kao
VITRECTOMY WITH INTERNAL LIMITING MEMBRANE PEELING FOR HIGHLY MYOPIC FOVEOSCHISIS/ Li-Feng ChiangChing-Yao TsaiLin-Chung WoungYen-Jui Chang
ACUTE INTRAOCULAR PRESSURE ELEVATION ATTACK FOLLOWING A 2.5 MG DOSAGE OF INTRAVITREAL INJECTION OF BEVACIZUMAB (AVASTIN): A CASE REPORT./ Pei-Kang LiuJong-Jer LeeIng-Chou LaiChih-Hsin Chen
CILIORETINAL ARTERY OCCLUSION COMBINED WITH NON-ISCHEMIC CENTRAL RETINAL VEIN OCCLUSION IN A YOUNG MAN WITH HYPERHOMOCYSTEINEMIA/ Sung-Ying HuangWei-Chun ChanLee-Jen Chen
PRESUMED OCULAR TUBERCULOSIS PRESENTING AS RETINAL OCCLUSIVE VASCULITIS--REPORT OF THREE CASES/ Chun-Fu LiuLing YeungYu-Chih LiuYih-Shiou Hwang
CENTRAL RETINAL ARTERY OCCLUSION BY ORBITAL PSEUDOTUMOR--A CASE REPORT/ Lien-Sheng LeeChun-Chen ChenChih-Chung LinHao-Chen ChangShiow-Wen Liou
INTRAVITREAL INJECTION OF BEVACIZUMAB AND FOCAL LASER PHOTOCOAGULATION FOR CHOROIDAL METASTATIC TUMORS--A CASE REPORT/ Yu-Fang HsuWen-Chiuan Wu
BILATERAL ORBITAL DIFFUSE LARGE B-CELL LYMPHOMA--A CASE REPORT/ Shang-Hsien YangI-Mo Fang
SUPERFICIAL ADNEXAL LYMPHANGIOMA: CASE REPORT AND LITERATURE REVIEW/ Yi-Ming HuangChieh-Chih TsaiShu-Ching KaoShui-Mei Lee
SPONTANEOUS REGRESSION OF INDIRECT CAROTID-CAVERNOUS SINUS FISTULA/ Shao-Jung LeeYoun-Shen BeeMuh-Chiou LinJiunn-Liang ChenChia-Jung ShenShwu-Jiuan Sheu
ACQUIRED OCULAR TOXOPLASMOSIS IN A PATIENT WITH SULFA ALLERGY--A CASE REPORT/ Wei-Chun ChanShawn H. TsaiLee-Jen Chen
交感性眼炎-病例報告/ 傅振男莊秋同林俊佑吳宗典許淑娟
原發性結霜樹枝狀血管炎之病例報告/ 莊秋同吳宗典許淑娟
LONG-STANDING TEMPORAL VISUAL FIELD DEFECT WITH PERIPAPILLARY PIGMENTARY CHANGES--TWO CASE REPORTS/ Jen-Pin SunPo-Ting YehChung-May Yang
 
   
 
   

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