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題名:BILATERAL CATARACTS AFTER PSORALEN AND LONG-WAVE ULTRAVIOLENT RADIATION(PUVA) TREATMENT FOR PSORIASIS     (14點)
年輕乾癬患者因PUVA治療誘發雙眼後囊性白內障之病例報告
著者:Chi-Ting Horng(洪啟庭) ;Kuang-Jen Chien(簡光仁) ;Daih-Iluang Kuo(郭代璜) ;Fu-An Chen(陳福安) ;Chien-Te Lin(林建德) ;Ming-Ling Tsai(蔡明霖) ;Po-Chuen Shieh(謝博銓)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:Psoriasis ; Cataracts ; Sunglasses
刊名:中華民國眼科醫學會雜誌
卷期:47卷1期(2008.3)
頁碼:54-60
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

日的:報告一位年輕男性乾癖思者因接受PUVA 治療多年後,誘發雙眼嚴重後囊性白內障。 方法:病例報告 結果:一位35 歲年輕男性,在皮膚科診斷為乾 癖後,安排一系列的PUVA 治療數年。近年來其因為 雙眼視力嚴重不良而至眼科就診。裸視雙眼均僅為 6/60 '裂隙燈檢查發現為嚴重後囊性白內障,但無法 配鏡矯正。病患逞陸續接受雙眼白內障超音波乳化術 合併人工水晶體植入,術後三個月時雙眼裸視均呈 6/6 '且在六個月的追蹤時間內並無明顯的併發症發 生。結論:目前治療乾癖的方法之一為口服 psoralen '同時接受紫外線A 的照射,稱為PUVA 治 療方式。不幸的照射過程中人體的水晶體極容易吸收 紫外線A; 另外口服的8-MOP 也容易在水晶體內擴 散,並與其中的蛋白質與去氧核醋核酸進行不可逆的 結合,進而形成渾濁現象。白內障的產生為接受 PUVA 治療的長期併發症之一,而後囊性白內障在年 輕乾癖患者更為少見,尤其是嚴重到必須接受手術治 療。一般而言眼科方面的症狀極容易被乾癖患者所忽 略,而最佳預防白內障的方法是在乾癖治療期間確實 配戴可吸收紫外線A 的太陽眼鏡。
Purpose: To report a case of bilateral cataracts in one young patient of psoriasis treated with PUVA which induced severe impairment of visual acuity. Method: Case repo比 Results: A 35-year-old male of psoriasis received oral 8 - MOP (8-methoxypsoralen) photo-chemotherapy and exposed to ultravilolet A for 8 years. Recently his best corrected vision were 6/60 in the both eyes on ocular examination. The slit lamp microscopy showed bilateral dense posterior sub-capsular opacity. Clear cornea incision wound of phacoemulsification combined with foldable IOL implantation was pe斤。rmed one by one. Three months later, his bilateral bare visual acuity returned to 6/6 and no other ocular complications were found during the 6 months follow-up. Conclusion: The efficacy of oral psoralen and long wave ultraviolent A radiation (known as PUVA) were popularly used as the treatment for psoriasis. Unfortunately, UVA is largely absorbed by the lens. Oral administered 8-MOP also diffuses in the lens and binds irreversible with DNA molecules and lens proteins. Long-term risks of PUVA including cataracts are relatively rare found in young people. The ocular symptoms may be neglected by the patients of psoriasis. The best method of minimizing the cataract formation is reminding them of the importance of wearing UVA-block protective sunglasses.


    

本卷期目次
中華民國眼科醫學會雜誌 47卷1期 (2008.3)
如何診斷正常眼壓青光眼/ 吳秀琛
INTRAVITREAL BEVACIZUMAB FOR CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION--A SHORT-TERM STUDY/ Yu-Lun LoCheng-Kuo ChengChi-Hsien PengTong-Sheng LeeChao-Chien HuTzu-En WuHueu-Chen LinPai-Huei PengChyi-Huey BaiHuey-Shyan Lin
我國與世界各國軍方空勤視力體檢之比較/ 洪啟庭蔡明霖劉峻正黃博宏吳怡昌袁本治孫卓卿
額前肌瓣前移術用於眼瞼下垂之矯正/ 張欣怡蔡顯揚袁漢良
CONJUNCTIVAL MUCOSA-ASSOCIATED LYMPHOID TISSUE (MALT) LYMPHOMA: REPORT OF 6 CASES/ Wan-Ju LeeSung-Huei TsengYing-Ting ChenHon-Chun ChengFu-Chin Huang
IRIS TUMOR AND SECONDARY GLAUCOMA AS INITIAL PRESENTATIONS OF LUNG CARCINOMA: A CASE REPORT/ Ching-Ya HuangKwou-Yeung Wu
ONE-MINUTE SCHIRMER TEST FOR BASAL TEAR SECRETION/ Yung-Ping TsuiWen-Lu ChenChun-Chi ChiangShih-Yuan HuangChiu-Chen HuangYi-Yu Tsai
BILATERAL CATARACTS AFTER PSORALEN AND LONG-WAVE ULTRAVIOLENT RADIATION(PUVA) TREATMENT FOR PSORIASIS/ Chi-Ting HorngKuang-Jen ChienDaih-Iluang KuoFu-An ChenChien-Te LinMing-Ling TsaiPo-Chuen Shieh
GRID PATTERN LASER TREATMENT FOR ATYPICAL CHRONIC RECURRENT CENTRAL SEROUS CHORIORETINOPATHY--CASE REPORT/ Yu-Kai WuCheng-Kuo Cheng
AIDS PRESENTING EARLY CYTOMEGALOVIRUS RETINITIS--A CASE REPORT/ Chieh-Feng ChengChien-Liang WuChih-Yu Chen
ACUTE ORBITAL COMPARTMENT SYNDROME IN A PATIENT WITH SINUSITIS AFTER LACRIMAL IRRIGATION--A CASE REPORT/ Chun-Hsien LiuHsiao-Hsuan TsaiPei-Yu LinChi-Te ChenChieh-Chih TsaiShu-Ching KaoWen-Ming Hsu
IN VIVO CONFOCAL MICROSCOPY OF COMBINED FUCHS' ENDOTHELIAL DYSTROPHY AND PRE-DESCEMET'S MEMBRANE CORNEAL DYSTROPHY--A CASE REPORT/ Chia-Ching HoHuey-Chuan ChengTzong-Shyne Liu
以急性視力受損為全身紅斑性狼瘡的初發表現--病例報告/ 陳俊寰劉美麟
外科手術成功解除因骨纖維結構不良症造成壓迫性視神經病變之病例報告/ 李美侖黃福進史敏秀
 
   
 
   

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