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題名:出血性結膜炎腺病毒和科沙奇病毒感染血管內皮細胞     (14點)
INFECTION OF VASCULAR ENDOTHELIAL CELLS WITH HEMORRHAGIC CONJUNCTIVITIS VIRUSES, ADENOVIRUSES AND COXSACKIEVIRUS
著者:張丞賢(Cheng-Hsien Chang) ;許明木(Ming-Muh Hsu) ;高英賢(Ying-Hsien Kao) ;林貴香(Kuei-Hsiang Lin)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:adenovirus ; enterovirus (coxsackievirus A type 24 variant) ; hemorrhage ; conjunctivitis
刊名:中華民國眼科醫學會雜誌
卷期:42卷4期(2003.12)
頁碼:397-403
語言:繁體中文
摘要: 中文摘要PDF ; 英文摘要PDF

流行性病毒角結膜炎為台灣常見之流行病,主要由腺病毒之亞屬 D 及腸病毒之柯沙奇病毒A24 型變異株所引起O 結膜下出血本為腸 病毒感染之特徵,但1995 至1997 年高醫調查結果發現腺病毒引起之 結膜炎亦有出血增加之趨勢O 更可怕的是最近在北美洲報告有大量之 鹿群因感染腺病毒而全身出血死亡。為了探討出血性結膜炎之致病機 轉,我們槍驗從結膜炎病人分離出來的腺病毒19 型、37 型及柯沙奇 病毒A24 型對人類濟帶血管內皮細胞的是否有感染力,實驗結果顯 示19 及37 型腺病毒20 株病毒中有18 株會產生血管內皮細胞病變, 而柯沙奇病毒則20 株中有17 株產生細胞病變。進一步實驗顯示柯沙 奇病毒A24 型變異株較腺病毒有較強之感染性O 接著又比較造成病 人結膜出血與不出血的病毒是否有毒性差異。但是在有結膜下出血與 無結膜下出血病人分離出之病毒株對人類膀帶血管內皮細胞的相對 感染力,兩手且間無顯著差異O 本研究証明了結膜炎病毒在体外無論出 血株或不出血株都會感染血管內皮細胞O
Epidemic viral conjunctivitis is a common infectious disease in Taiwan. The main causative agents are subgenus 0 of adenoviruses and caxsackievirus A type 24 varaint of enterovirus. Subconjunctival hemorrhage is a characteristic of enteroviral conjunctivitis. However, adenovirus-associated conjunctivitis also exhibited an increased incidence of subconiunctival hemorrhage in a s盯vey of Kaohsiung Medical University 企om 1995 to 1997. Moreover, animal adenovirus was reported to cause a systemic hemorrhage and lethal disease in deer of North America. To study the pathogenesis of bleeding after an ocular infection of the adenoviruses and coxsackievirus, we tested the susceptibi1ity of vascular endothe1ial cells to adenovirus type 19 (Ad19) and type 37 (Ad3 7) and coxsackievirus A type 24 variant (CA24v). The results showed that in 20 S仕ains of Ad19 or Ad37, eighteen strains exhibited cytopathic effects in vascular endothelial cells while 17 in 20 strains of CA24v showed cytopathic effects. By comparing the relative TCI050 of infected HUVEC and HeLa, CA24v exhibited a higher infectivity than adenoviruses. Furthermore, we compared the endothelial susceptibility to hemorrhagic and non-hemorrhagic s甘ains of viruses. However, no significant difference of infectivity between hemorrhagic and non-hemorrhagic strains of adenoviruses and CA24v was noted. This study exhibited that vascular endothelial cells are in vitro susceptible to conjunctivitis viruses, irrespective of hemorrhagic or non-hemorrhagic s甘ams.


    

本卷期目次
中華民國眼科醫學會雜誌 42卷4期 (2003.12)
SURVEY OF INDICATIONS AND RESUL TS OF VITREORETINAL SURGERY IN A REGIONAL HOSPITAL/ Chang-Sue YangChing-Yao TsaiTing-Jia ChangLin-Chung Woung
出血性結膜炎腺病毒和科沙奇病毒感染血管內皮細胞/ 張丞賢許明木高英賢林貴香
糖尿病整體照護──視網膜病變篩檢流程之評估/ 謝瑞玟陳立仁韋熙
MARGINAL CORNEAL ULCER AFTER CATARACT SURGERY IN PATIENT WITH RHEUMATOID ARTHRITIS/ Hsuei-Yuh LuTing-Wen Wang
FLAP SUTURING TO TREAT RECALCITRANT FLAP STRIAE AFTER LASER IN SITU KERA TOMILEUSIS/ Ming-Cheng TaiJen-Chieh LiuDa-Wen Luand Cheng-Jong Chang
JUVENILE RETINOSCHISIS──CASE REPORT/ Shih-Yu ChouDer-Chong TsaiFenq-Lih LeeWen-Ming Hsu
CHALCOSIS OCULI──A CASE REPORT/ Chien-Liang WuChien-Ming LiaoChung-May YangAi-Ho Wang
雷射角膜層狀塑型術後瀰漫性層狀角膜炎之病例報告/ 沈應誠馮士釗李怡芬
 
   
 
   

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