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題名:配戴各類型隱形眼鏡下人類免疫球蛋白A之比較     (18點)
THE ANALYSIS OF HUMAN SECRETORY IMMUNOGLOBULIN A IN VARIOUS CONTACT LENSES WEARERS
著者:洪啟庭(Chi-Ting Horng) ;鍾漢軍(Hang-Chium Chung) ;陳福安(Fu-An Chen) ;劉峻正(Chun-Cheng Liu) ;陳建同(Jiann-Tong Chen) ;孫昭玲(Jau-Ling Suen)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:Immunoglobulin A ; Orthokeratology ; tear ; contact lenses
刊名:中華民國眼科醫學會雜誌
卷期:45卷4期(2006.12)
頁碼:398-406
語言:繁體中文
摘要: 中文摘要PDF ; 英文摘要PDF

目的:研究配戴各式隱形眼鏡時淚液中免疫球蛋白A 之數值, 並觀察其免疫反應與在臨床上之影響O 方法:本實驗蒐集100 雙眼近視眼志願者淚液,年紀介於18 至 25 歲之間,共分為四組:第一組25 位不曾配戴隱形眼鏡者;第二組 25 位為配戴軟式隱形眼鏡者;第三組為25 位配戴硬式高透氧型隱形 眼鏡者;第四組為25 位接受夜間角膜塑型術的近視患者O 每位受測 者隨機選取一眼,於白天收集其刺激型淚液,隨後以免疫酵素呈色法 分析其中的全免疫球蛋白A(IgA) 的量O 同時也觀察每位相對應眼之 淚液試驗結果、結膜充血現象、結膜乳頭大小與角膜上皮之螢光染色 情形O 結果:第一組正常人IgA 平均為39.2:l:: 16.0μg/ml' 弟三組使用 硬式隱形眼鏡者IgA 平均為42.3士8.7μg/ml ,兩者差異不大O 第二組 配戴軟式隱形眼鏡者IgA 平均為169 .4土62.8μg/ml ,有升高的現象O 第四組夜間使用角膜塑型片IgA 平均為410.1 土70.5μg/ml' 明顯的比 正常組上升將近10 倍左右O 同時在臨床上我們也觀察到使用軟式隱 形眼鏡與角膜塑形片者之乾眼、結膜充血、巨大乳頭狀結膜炎與角膜 上皮缺陷等現象均較為明顯O 結論:隱形眼鏡目前廣為使用,先進的角膜塑型術更解決了部分 學童的屈光問題,其功效甚大O 但是長期配戴軟式隱形眼鏡者極容易 誘發發炎反應,尤其夜間使用角膜塑型片者更為明顯O 如何指導近視 眼患者安全配戴隱形眼鏡,尤其是角膜塑型片之使用,絕對是一種醫 療行為O 避免後續感染與視力喪失等問題之發生,更應該是國內眼科 醫師的權利與天職O
Purpose: To determine secretory IgA in the tears of various contact lens wearers and evaluate the effects of immune reaction in clinics. Method We collected the stimulated tears of 100 myopic volunteers between 18 to 25 age years old. The su吋ects were divided into four categories: non-contact lenses wears (n =25), daily-wear soft lenses wearers (n=25), daily-wear rigid gas-permeable lenses wearers (n= 25), and ovemight ortho-k lens wearers (n=25). The immunglobulins A of tear samples were measured by ELlSA (enzyme-linked immunosorbent assay). The schirmer test 1, degree of conjunctival redness, papillary formation, corneal staining with fluorescein were observed at the same time. Result : We determined the levels of IgA and the results revealed that (1) the normal group are mean 39 .2::t 16.0μg/ml , (2) daily-wear soft lenses wearers have a significant1y higher mean, up to 169 .4土62.8 時Iml (P < 0.05), (3) ovemight ortho-k lens wearers exhibit mean 410. ]::t70.5 Ilg!ml, 10 times greater than that of the normal group (P < 0.05). It is obvious that the soft contact lenses more easily induce inflammation, especially the ovemight users, and (4) the IgA of daily-wear RGP wearers, average 42 .3士8.7 1lg!m l. The relatively lower immune reaction may be considered. In clinics, dry eye, conjunctival redness, contact lens-induced papillary conjunctivitis, comeal epithelial defects of daily-wear soft lenses and ovemight ortho-k lens wearers were apparent1y found. Conclusion A moderate to severe degree of immune reaction, symptoms and signs in daily-wear soft lenses and ovemight ortho-k lens wearers were noted. Instructing all contact les wearers to care for themselves and prevent from infection and visual loss should be the duty and right of all ophthalmologists.


    

本卷期目次
中華民國眼科醫學會雜誌 45卷4期 (2006.12)
OPHTHALMOLOGIC ABNORMALITIES IN TEENAGERS WITH DOWN'S SYNDROME/ Mei. Ling LiuYi-Sheng ChangHon-Chun ChengMin-Hsiu ShihSung-Huei TsengChia-Lia Teng
CIRCUMSCRIBED CHOROIDAL HEMANGIOMA COMPARISON OF OUTCOMES BY TREATMENT WITH LASER PHOTOCOAGULATION OR TRANSPUPILLARY THERMOTHERAPY/ Chih-Wei ShihChang-Hao YangChung-May YangJen-Shang HuangChang-Pin LinTzyy-Chang HoMuh-Shy Chen
PARANASAL SINUSITIS FOLLOWING ORBITAL DECOMPRESSION IN PATIENTS WITH GRAVES' OPHTHALMOPATHY/ Lan LeeLih MaShu-Ya WuYueh-Ju Tsai
BREAKDOWN OF THE BLOOD-AQUEOUS BARRIER CAUSED BY ARGON LASER PANRETINAL PHOTOCOAGULATION IN THE RABBIT RETINA/ Muh-Shy ChenChing-Chung ChangSzu-Yuan LinPeng-Chen WangPing-Kang Hou
OUTCOMES OF TRABECULECTOMY VERSUS TRABECULECTOMY COMBINED WITH DEEP SCLERECTOMY IN GLAUCOMA PATIENTS──15-MONTH FOLLOW-UP (A PRELIMINARY REPORT)/ Min-Wen HsuShiuh-Liang HsuKwou-Yeung Wu
VITRECTOMY WITHOUT INTERNAL LIMITING MEMBRANE PEELING FOR MACULAR RETINOSCHISIS IN HIGHLY MYOPIC EYES/ Shu-I YehWei-Chun ChanLee-Jen Chen
配戴各類型隱形眼鏡下人類免疫球蛋白A之比較/ 洪啟庭鍾漢軍陳福安劉峻正陳建同孫昭玲
斜視術後類固醇引起之高眼壓/ 李美侖黃福進史敏秀
JUXTAPAPILLARY CHOROIDAL MELANOMA──A CASE REPORT/ Feng-Chi LinJiann-Torng ChenChiao-Hong ChenPo-Liang ChenDa-Wen Lu
EOSINOPHILIC LYMPHOGRANULOMA (KIMURA'S DISEASE) OFLACRIMAL GLAND──A CASE REPORT/ Chia-Ling LeePei-Hisn HuCheng-Hsien ChangShiuh-Liang HsuMing-Yang Sul
AMNIOTIC MEMBRANE TRANSPLANTATION FOR PERSISTENT CORNEAL EPITHELIAL DEFECT AND ULCERATION/ Chia-Hung LiMing-Cheng TaiJiann-Tomg ChenI Jy-Been LiangDa-Wen Lu
RETINALASTROCYTIC HAMARTOMA COMPLICATED WITH VITREOUS HEMORRHAGE IN TUBEROUS SCLEROSIS/ Chao-Kung LuShih-Jen ChenFenq-Lih LeeWen-Ming Hsu
ANTERIOR CAPSULAR PHIMOSIS AFTER SUCCESSFUL SURGERY FOR A PATIENT WITH TRAUMATIC ATARACT: CASE REPORT/ Chih-Hsien HsiaoCheng-Jong ChangPo-Liang Chen
CONJUNCTIVAL SEBACEOUS CARCINOMA WITH AN UNUSUAL CLINICAL COURSE──A CASE REPORT/ Hsiao-Yen ChenHon-Chun ChengSung-Huei TsengYi- Chang Tsai
FAMILIAL EXUDATIVE VITREORETINOPATHYA──CASE REPORT/ Chun-Pin TsaiDer-Chong TsaiLing-Ing LauFenq-Lih LeeWen-Ming Hsu
 
   
 
   

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