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題名:Carteolol(ArteopticR)之臨床評估及心血管作用-內因性擬交感神經作用之探討     (14點)
CLINICAL EVALUATION AND CARDIOVASCULAR EFFECTS OF CARTEOLOL (ARTEOPTICR)---THE ROLE OF ISA
著者:陳美如(Mei-Ju Chen) ;周清光(Joe C.K. Chou) ;劉榮宏(Jorn-Hon Liu)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:glaucoma ; Carteolol ; Intraocular Pressure ; ISA
刊名:中華民國眼科醫學會雜誌
卷期:38卷1期(1999.3)
頁碼:50-56
語言:繁體中文
摘要: 中文摘要PDF ; 英文摘要PDF

Carteolol(ArteopticR)是目前唯一具有ISA(內因性擬交感神經作用)的非選擇性β阻斷劑。本篇試驗對象為原先點用0.5% Timolol的POAG患者13名及從未曾點藥的NTG患者13名,經篩選後開始點用2% Carteolol,一日兩次。分別於用藥前、用藥後第2,4,8,12週進行眼部檢查,並測量眼壓、收縮壓、舒張壓、脈搏及記錄自覺症狀。結果予以記錄並做統計分析。我們發現POAG患者改用2% Carteolol後眼壓仍能維持良好的控制,而NTG患者的眼壓於使用4,8,12週後分別下降2.8、1.3及1.0mmHg,降幅為7-19%,達統計學上的意義。不論POAG或NTG患者,點藥後的血壓約有下降的情形,收縮壓平均下降4~11毫米汞柱,舒張壓則為2~8毫米汞柱。而在脈搏方面,兩組降低的幅度皆在每分鐘心跳降低3次的範圍內。不管是收縮壓、舒張壓或是脈搏,兩組的降幅並不具有統計學上的意義。相較於國內外文獻有關非選擇性β阻斷劑(Timolol)造成的血壓降低、心跳變慢等嚴重副作用的報告,Carteolol對於全身性心血管作用的影響較小,對於年紀大,心肺功能較差,或是高危險群的NTG患者來說,應是較佳的選擇。
Carteolol (ArteopticR) is the only one non-selective Beta-blocker with ISA (Intrinsic Sympathomimetic Activity) now. Thrirteen POAG patients under 0.5% Timolol and thirteen NTG without treatment patients were enrolled in this study. All patients had complete eye examinations and systemic vital signs checkup before and after Carteolol use. IOP, SBP, DBP, PR, subjective symptoms were taken in the visits scheduled at 2,4,8,12 weeks with data recorded and analysed. After 12 weeks therapy, Carteolol reduced IOP approximately 7-19% in patients with NTG with statistically significance and achieved good IOP control in patients with POAG. The reduction of SBP ranged between 4 and 11 mmHg and DBP between 2 and 8 mmHg while the PR reduction was less than 3 bpm. No statistically significant difference was found in the SBP, DBP and PR in both groups. Most patients reported no subjective symptoms except few gritty sensation and transient blurred vision. Beta-adrenergic antagonists with ISA have been shown to cause less systemic cardiovascular effects in literatures. Therefore, they may be useful in patients in whom old aged, bradycardia, poor cardiovascular function, or high risk NTG is a Problem.


    

本卷期目次
中華民國眼科醫學會雜誌 38卷1期 (1999.3)
INDOCYANINE GREEN ANGIOGRAPHIC FEATURES IN IDIOPATHIC SUBFOVEAL CHOROIDAL NEOVASCULARIZATION/ Wei-Li ChenPing-Kang HouMuh-Shy Chen
A TWO YEARS STUDY OF CORNEAL TOPOGRAPHIC STABILITY FOLLOWING RADIAL KERATOTOMY/ Sung-Huei TsengJia-Jane LeuFred K Chen
眼底缺損合併小眼角膜-家族病例報告/ 王錦銘陳建同周秉義
全身性紅斑狼瘡急性發作期導致暫時性高度近視及結膜水腫--病例報告/ 梁中玲李瑞鋒郭錫恭賴盈州鄭添財
RECONSTRUCTION OF LARGE ORBITAL FRACTURES WITH HIGH-DENSITY POROUS POLYETHYLENE CHANNEL IMPLANTS/ Yu-Hong LaiCheng-Hsien ChangHwei-Zu Wang
老年性?斑部病變之境界不明脈絡膜新生血管的灌流變化/ 陳世真李鳳利楊昌叔林伯剛李安斐劉榮宏
碳酸酐?抑制劑6-Hydroxyethoxy-2-benzothiazole Sulfonamide靜脈注射後之兔眼藥物動力學/ 呂大文高繼文江樵熹張澶榮林秋燕
碳酸酐?抑制劑6-Hydroxyethoxyzolamide局部點眼後之兔眼藥物動力學/ 呂大文江樵熹張澶榮林秋燕
Carteolol(ArteopticR)之臨床評估及心血管作用-內因性擬交感神經作用之探討/ 陳美如周清光劉榮宏
復興鄉色覺調查/ 高玲玉史麗珠林淑梅梁有松
高雄地區九所高中職專二年級學生近視狀況與環境因素之研究/ 陳文甲王惠珠李穎勳吳孟憲陳育芬許俊傑陳正僓
台中市中小學生斜視罹患率之調查/ 林慧茹廖惠芬李揚銘黃韻如蔡慶皇黃瓊瑢陳宏任林正介李采娟
經濟簡便的後房人工水晶體鞏膜固定術/ 陳家祿王泰元劉秀雯林人傑邱正仁
NOCARDIA ASTEROIDES CORNEAL ULCER--A CASE REPORT/ Ching-Liang KuoHui-Kang MaRay Jui-Fang Tsai
ISOLATED MYOSITIS OF THE LEVATOR MUSCLE/ Inn-Yaing LeeJeng-Shyong Shyu
TRANSNASAL ENDOSCOPIC APPROACH FOR ORBITAL DECOMPRESSION OF THYROID ORBITOPATHY--CASE REPORT/ Cheng-Hsien ChangHwei-Zu WangChih-Feng Tai
小兒巧克力囊腫的血液動力分析-病例報告/ 林宜蓉康孟?
 
   
 
   

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