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題名:後房注射Alpha-chymotrypsin誘發之高眼壓兔眼模式之房水動力學變化     (20點)
A COMPARISON OF INTRAOCULAR PRESSURE DYNAMICS BETWEEN ALPHA-CHYMOTRYPSIN POSTERIOR CHAMBER INJECTION INDUCED OCULAR HYPERTENSIVE RABBIT EYES AND NORMAL EYES
著者:呂大文(Da-Wen Lu) ;江樵熹(Chiao-His Chiang) ;張澶榮(Charn-Jung Chang) ;林秋燕(Chiu-Yen Lin)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:Glaucoma ; Animal Model ; Alpha-chymotrypsin-induced Ocular Hypertensive Rabbit Eyes (AOHRE) ; Relationship
刊名:中華民國眼科醫學會雜誌
卷期:38卷2期(1999.6)
頁碼:215-224
語言:繁體中文
摘要: 中文摘要PDF ; 英文摘要PDF

在研究青光眼的機轉或是降眼壓藥物作用機轉時,若能建立類似人類青光眼變化的動物模式則其研究結果較能預測在人體上真正的變化。由於Alpha-chymotrypsin後房注射產生之高眼壓兔子常被用來當作模式動物,而其房水動力學變化未曾有文獻報告過,故在本研究中利用Alpha-chymotrypsin注射入兔眼後房以研究其房水動力學變化,結果發現兔眼經Alpha-chymotrypsin注射後眼壓即急劇升高,但在術後兩週內眼壓有較大之起伏變化,自二個月後至二年之間,經Alpha-chymotrypsin誘發之青光眼,其眼壓(平均值38.4mmHg)則皆維持在較正常眼(平約值18.3 mmHg)為高之水平(p<0.01)。此外在高眼壓兔眼有較大之前房體積、虹膜-睫狀體複合體有明顯充血現象及水晶體有高比例之脫位(38%)情形。 利用此一模式研究不同體積之Balanced Salt Solution (BSS)瞬時注入前房後,等量之體積是否產生相同之眼壓上升時,可以發現其再現性良好。若逐次微量的將BSS加入前房中可以觀察到眼壓上升之現象:加入之體積愈多,眼壓上升之幅度愈大,但在高眼壓眼需加入較正常眼為多之BSS體積始可達同幅度之眼壓上升。若以眼壓開始上升至完全回復至基線(Baseline)的時間為過量前房體積之排除時間,則可以發現在正常眼所加入之BSS體積量與排除時間之關係為拋物線形,而高眼壓眼由於額外加入之體積在前房會有逐漸蓄積的現象,故基線不斷的升高,因此無法建立排除時間與加入體積之關係。
When we study the mechanisms of glaucoma or antiglaucoma agents, it is beneficial and helpful to have animal models that simulate the changes of human glaucoma. Alpha-chymotrysin-induced ocular hypertensive rabbit eyes (AOHRE) were frequently used as an animal model in studying glaucoma, yet the changes of aqueous humor dynamics of such a model have never been described. In this study, we reported the aqueous humor dynamics in AOHRE. It was found that the intraocular pressure (IOP) of the rabbits dramatically increased immediately after the injection of alpha-chymotrypsin. Although there was variation in IOP levels within the first two weeks after alpha-chymotrypsin injection, yet from two months to two years, the AOHRE showed significantly elevated IOPs (mean: 38.4 mmHg) than those of the normal controls (mean: 18.3 mmHg) (p<0.01). In addition to that, the AOHRE had larger anterior chamber volume, obvious injection on the surface of iris-ciliary body complex and higher incidence of lens dislocation (38%). In studying the relationship between extra-added volumes and IOPs of AOHRE and normal controls, it was found that the reproducibility was good between instant anterior chamber injection of Balanced Salt Solution (BSS) and IOP changes. The larger the amount injected into the anterior chamber, the higher the IOP level would be. But in AOHRE, it needed more volumes of BSS than in normal controls to result in the same amplitude of IOP elevation. In addition, if we defined that the time needed for the extra-volume of BSS to be excreted as excretion time, it was found that the excretion profile for the normal controls would be a parabolic curve, while in AOHRE, due to gradual accumulation of BSS in the anterior chamber, there was no such relationship existed.


    

本卷期目次
中華民國眼科醫學會雜誌 38卷2期 (1999.6)
A NEW TECHNIQUE FOR REPOSITIONING A DISPLACED LACRIMAL SILICONE TUBE/ Yi-Yu TsaiFu-Chin HuangSung-Huei Tseng
高度近視病人之閃爍融合閾值的變化/ 陳寶全翁林仲楊正烽施永豐林隆光
後房注射Alpha-chymotrypsin誘發之高眼壓兔眼模式之房水動力學變化/ 呂大文江樵熹張澶榮林秋燕
慢性青光眼神經盤上單一扭曲之靜脈環狀血管/ 黃敏生周景清
早產兒視網膜病變之發生率及發展過程/ 藍郁文吳愛卿
安全氣囊造成眼部傷害之分析/ 郭淑純蔡武甫
BILATERAL SEROUS RETINAL DETACHMENT IN ASSOCIATION WITH PREECLAMPSIA--A CASE REPORT/ Huei-Chen HungShih-Chi LiuYao-I LinShwu-Jiuan Sheu
RETINAL PIGMENT EPITHELIAL HAMARTOMA--A CASE REPORT/ Man-Ching HuangAi-Ching Wu
HORIZONTAL TRANSPOSITION OF THE VERTICAL RECTUS MUSCLES TO TREAT CYCLOTORSION-A CASE REPORT/ Ai-Hou WangChun-Hung LiuMei-Ru ShihHsuei-Yuh Lu
FIBROUS DYSPLASIA ASSOCIATED WITH OPTIC ATROPHY--A CASE REPORT/ Pei-Ching DingRong-Kung TsaiChung-Yi Sun
ORBITAL LYMPHOBLASTOMA---A CASE REPORT/ Hon-Chun ChengYi-Sheng ChangJiann-Shiuh ChenYing-Tai Jin
WAARDENBURG SYNDROME--REPORT OF THREE CASES IN A FAMILY/ Cheung-Kei WongElsa Lin-Chin MaiYao-Huei Lee
源於中腦腫瘤之班尼第症候群-病例報告/ 陳昭杰蘇娟儀陳文甲蘇明揚蔡榮坤
眼眶部偽腫瘤-病例報告/ 林義博沈劍西尤之浩
外傷後虹彩表皮囊腫自發性破裂-病例報告/ 林蓓雯林淑妍鄧美琴夏恆健
綠膿桿菌性角膜感染之視力重建-病例報告/ 葉啟清江元弘蔡武甫
白內障術後角膜後纖維增生-壹病例報告/ 蔡悅如黃朝銘彭曄
 
   
 
   

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