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1
題名:Is antiphospholipid antibody related to outcome of lupus nephritis?-A 2-year analysis     (14點)
抗磷脂抗體是否為紅斑性狼瘡腎炎的預後因子
著者:Wen-Chan Chiu(邱文燦) ;Shun-Chen Huang(黃純真) ;Chung-Jen Chen(陳忠仁) ;Chung-Yuan Hsu(許鐘元) ;Tsong-Shing Yang(楊聰信) ;Ching-Lan Chou(周靜蘭) ;Fu-Mei Su(蘇富美) ;Yu-Jih Su(蘇昱日) ;Shan-Fu Yu(尤珊富) ;Chun-Kai Chiu(邱俊凱) ;Ying-Chou Chen(陳英州) ;Han-Ming Lai(賴漢明) ;Tien-Tsai Cheng(鄭添財)
出版地區:台灣
出版城市:台中市
學科:醫學綜合
關鍵字:狼瘡腎炎 ; 長期預後 ; 抗磷脂抗體 ; lupus nephritis ; prognosis ; International Society of Nephrology and the Renal Pathology Society (ISN/RPS) classification ; antiphospholipid antibody
刊名:Formosan Journal of Rheumatology
卷期:24卷1、2期合刊(2010.12)
頁碼:22-28
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:研究抗磷脂抗體對紅斑性狼瘡腎炎的腎功能預後的影響。方法:本研究回溯性調閱本院過去經診斷為紅斑性狼瘡腎炎病人之病歷,他們都符合美國風濕病醫學會紅斑性狼瘡分類標準,並於1986-2007期間在本院接受過腎臟切片,經確認為狼瘡性腎炎。但我們只收集有驗過至少一項抗磷脂抗體試驗的病患之人口統計學,血清學資料及治療內容。主要觀察重點為24個月內達到兩倍血中肌酸酐或末期腎病變/死亡的比率。結果:我們總共收錄66病患,其中包括55個女性及11個男性。平均年齡30.53±11.09歲。18位病患抗磷脂抗體陽性(27.3%)(Ⅰ),餘下48位病患為陰性(72.7%)(Ⅱ)。在2年的存活分析發現抗磷脂抗體陽性的病患(Ⅰ)有較好的腎臟預後(p<0.05)。結論:與之前的研究相反的是抗磷脂抗體陽性在我們狼瘡腎炎的病患可能有較好的腎臟預後。
Objective: To investigate the impact of antiphospholipid antibodies (aPLA) on renal outcome in lupus nephritis (LN). Materials and Methods: A retrospective chart review study of patients with biopsy-proven LN was conducted between 1986 and 2007 at Chang Gung Memorial Hospital in Kaohsiung. All of the patients fulfilled the systemic lupus erythematosus classification criteria of the American College of Rheumatology and had histopathological findings compatible with LN. Only those patients whose aPLA, including anti-cardiolipin antibody, anti-β2GPI antibody, Venereal Disease Research Laboratory test, and lupus anticoagulant had been checked were recruited. We reviewed the charts and collected the demographics, clinical characteristics, serological parameters, and treatment courses of the patients recruited. The renal outcome end point was either end-stage renal disease or doubling of serum creatinine within 24 months Results: A total of 66 subjects were recruited, including 55 females and 11 males. The mean age was 30.5±11.1 years. aPLA was present in 18 patients (27.3%) (group Ⅰ), and 48 patients (72.7%) (group Ⅱ) had negative test results. The seropositive ratios of anti-dsDNA and anti-RNP in group Ⅰwere significantly higher (p=0.023 and 0.026) than in group Ⅱ, respectively. There was no statistical difference in other parameters between the groups. The subjects in group Ⅰ had a more favorable (p=0.038) renal outcome after 2 years of follow-up. Conclusions: Contradictory to previous studies, the presence of aPLA in patients with LN is probably associated with a better renal outcome.


    

本卷期目次
Formosan Journal of Rheumatology 24卷1、2期合刊 (2010.12)
Increased serum IFN-γ in women with a history of repeated implantation failures after in vitro fertilization and embryo transfer/ Wei-Ting HungYi-Ming ChenMing-Jer ChenDer-Yuan ChenJoung-Liang LanHsin-Hua Chen
Pott's disease-a retrospective study of 35 patients/ Chun-Kai ChiuYu-Jih SuHan-Ming LaiChung-Jen ChenTien-Tsai Cheng
Is antiphospholipid antibody related to outcome of lupus nephritis?-A 2-year analysis/ Wen-Chan ChiuShun-Chen HuangChung-Jen ChenChung-Yuan HsuTsong-Shing YangChing-Lan ChouFu-Mei SuYu-Jih SuShan-Fu YuChun-Kai ChiuYing-Chou ChenHan-Ming LaiTien-Tsai Cheng
Prognostic factors of survival in patients with dermatomyositis and polymyositis/ Hsiao-Chun ChangYeong-Jian Jan WuShue-Fen LuoHuei-Huang HoLieh-Bang LiouJi-Yih ChenWen-Pin TsaiChang-Fu KuoChung-Han YangI-Jung ChenKuang-Hui Yu
Myelitis in patients with systemic lupus erythematosus/ Chung-Yuan HsuWen-Chan ChiuTsong-Shing YangChing-Lan ChouYu-Jih SuShan-Fu YuChun-Kai ChiuYing-Chou ChenHan-Ming LaiTien-Tsai ChengChung-Jen Chen
Outcome of lupus nephritis-A 5-year analysis/ Tsong-Shing YangShun-Chen HuangChung-Jen ChenChung-Yuan HsuWen-Chan ChiuChing-Lan ChouFu-Mei SuYu-Jih SuShan-Fu YuChun-Kai ChiuYing-Chou ChenHan-Ming LaiTien-Tsai Cheng
Association of high sensitivity C-reactive protein with hyperuricemia in Taiwanese patients with gout/ Ming-Han ChenWei-Sheng ChenHui-Ting LeeChang-Youh TsaiChung-Tei Chou
Angiopoietin-1 and endoglin are not associated with pulmonary arterial hypertension in patients with systemic lupus erythematous/ Ling-Jung YenHsiu-Man KengChin-Chang ChengJiung-Jun ChuChieh-Mei HsuXin-Tian LinJui-Cheng TsengJui-Chieh HuLing-Ying Lu
Metabolic syndrome in patients with rheumatoid arthritis: association of lifestyle with anthropometric measurements/ Ming-Fu ChenYi-Ming ChenDer-Yuan ChenJoung-Liang Lan
Ruptured Baker's cyst in patients with rheumatic diseases: analysis of 235 Baker's cysts in 198 patients/ Song-Feng YehDeh-Ming ChangJenn-Haung LaiChen-Hung ChenTsung-Yun HouSan-Yuan KuoChi-Sheng ChiouChi-Ching Chang
Clinical and serological features of patients with anti-Jo-1 antibodies/ Ting-Hui ChangSong-Chou HsiehChia-Li Yu
Distinct MHC class Ⅰ and class Ⅱ alleles in Taiwanese patients with ankylosing spondylitis/ Bao-Bao HsuMing-Chi LuKuo-Liang YangKuang-Yung HuangChien-Hsueh TungSu-Qin LiuNing-Sheng Lai
Sonographic findings of Weber Christian disease involving the breasts: a case report/ Kuang-Yung HuangYi-Ming ChenDer-Yuan ChenHsin-Hua Chen
Refractory chylothorax in a patient with systemic lupus erythematosus: case report/ Bao-Bao HsuChien-Hsueh TungMing-Chi LuKuang-Yung HuangNing-Sheng Lai
Multicentric reticulohistiocytosis mimicking rheumatoid arthritis in a 35-year-old woman-case report/ Chyou-Shen LeeMei-Eng TuTien-Ling Chen
"Hide-bound" bowel sign in a patient with progressive systemic sclerosis and chronic intestinal pseudo-obstruction/ Pei-Chen Hsu
 
   
 
   

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