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1
題名:Outcome of lupus nephritis-A 5-year analysis     (12點)
紅斑性狼瘡腎炎的預後-五年分析報告
著者:Tsong-Shing Yang(楊聰信) ;Shun-Chen Huang(黃純真) ;Chung-Jen Chen(陳忠仁) ;Chung-Yuan Hsu(許鐘元) ;Wen-Chan Chiu(邱文燦) ;Ching-Lan Chou(周靜蘭) ;Fu-Mei Su(蘇富美) ;Yu-Jih Su(蘇昱日) ;Shan-Fu Yu(尤珊富) ;Chun-Kai Chiu(邱俊凱) ;Ying-Chou Chen(陳英州) ;Han-Ming Lai(賴漢明) ;Tien-Tsai Cheng(鄭添財)
出版地區:台灣
出版城市:台中市
學科:醫學綜合
關鍵字:狼瘡腎炎 ; 長期預後 ; Lupus nephritis ; prognosis ; ISN/RPS classification
刊名:Formosan Journal of Rheumatology
卷期:24卷1、2期合刊(2010.12)
頁碼:44-49
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:調查第四期紅斑性狼瘡腎炎的長期預後並分析影響預後因子。方法:本研究回溯性調閱本院157位過去經診斷為紅斑性狼瘡腎炎病人之病歷,他們都符合美國風濕病醫學會紅斑性狼瘡分類標準並於1986-2004期間在本院接受過腎臟切片,經確認為狼瘡性腎炎。但我們只收集符合2003 ISN/RPS第四期紅斑性狼瘡腎炎病患之人口統計學,血清學資料及治療內容。主要觀察重點為60個月內達到兩倍血中肌酸酐(Cr)(Ⅰ)及末期腎病變(ESRD)/死亡(Ⅱ)的比率。結果:我們總共收錄75位符合2003 ISN/RPS第四期紅斑性狼瘡腎炎病患之資料,其中包含13位男生,62位女生。平均年齡25.9±9.7歲。五年後16人(21.3%)達到觀察重點(Ⅰ),15人(20%)達到觀察重點(Ⅱ)。其中沒有發展成兩倍Cr者比達到兩倍Cr者,有較高(14.5±2.1)活動指數(activity index, AI)(HR=0.552, CI=0.351-0.870, p=0.01)。沒有發展成ESRD/death者比達到者的AI為14.4±2.2 vs. 13.5±2.3(HR=0.666, CI=0.443-1.000, p=0.05)。結論:第四期紅斑性狼瘡腎炎在末期腎病變/死亡方面達到五年長期存活預後的比率為80%,略低於其他的調查。另外腎臟切片時有較高的AI是好的腎臟預後因子。
Objective: To investigate the long-term outcome of class IV lupus nephritis (LN) and to analyze its prognostic factors. Materials and Methods: We performed a retrospective chart review study of 157 patients with LN between January 1986 and June 2004 in Chang Gung Memorial Hospital at Kaohsiung. All of these LN patients fulfilled the systemic lupus erythematosus classification criteria of the American College of Rheumatology and had histopathological findings of LN. Only those pathology-proved subjects with class IV by 2003 ISN/RPS classification were recruited. We reviewed the charts and collected the demographic data, serological parameters, and treatment courses of subjects recruited. The end point of renal outcome were doubling of serum creatinine (Ⅰ) and end stage renal disease (ESRD)/death (Ⅱ) within 60 months after renal biopsy Results: A total of 75 subjects were recruited, including 13 male and 62 female. Mean age was 25.9±9.7 year. Five years after renal biopsy, 16 subjects (21.3%) developed outcome Ⅰ and 15 subjects (20.0%) developed outcome Ⅱ. Those who did not develop outcome Ⅰ had higher mean (14.5±2.1) activity index (AI) than that (13.1±2.5) of those did (HR=0.55, CI=0.35-0.87, p=0.01). For those who did not develop outcome Ⅱ, the mean AI was also higher than those who did (14.4±2.2 vs.13.5±2.3, HR=0.67, CI=0.44-1.00, p=0.05). Conclusions: The 5-year renal survival of current series, in terms of ESRD/death, was 80% and this was not as favorable as those reported in the other investigations. High activity index at biopsy is a predictor of favorable prognosis of long-term renal outcomes in case that aggressive treatment had been given.


    

本卷期目次
Formosan Journal of Rheumatology 24卷1、2期合刊 (2010.12)
Increased serum IFN-γ in women with a history of repeated implantation failures after in vitro fertilization and embryo transfer/ Wei-Ting HungYi-Ming ChenMing-Jer ChenDer-Yuan ChenJoung-Liang LanHsin-Hua Chen
Pott's disease-a retrospective study of 35 patients/ Chun-Kai ChiuYu-Jih SuHan-Ming LaiChung-Jen ChenTien-Tsai Cheng
Is antiphospholipid antibody related to outcome of lupus nephritis?-A 2-year analysis/ Wen-Chan ChiuShun-Chen HuangChung-Jen ChenChung-Yuan HsuTsong-Shing YangChing-Lan ChouFu-Mei SuYu-Jih SuShan-Fu YuChun-Kai ChiuYing-Chou ChenHan-Ming LaiTien-Tsai Cheng
Prognostic factors of survival in patients with dermatomyositis and polymyositis/ Hsiao-Chun ChangYeong-Jian Jan WuShue-Fen LuoHuei-Huang HoLieh-Bang LiouJi-Yih ChenWen-Pin TsaiChang-Fu KuoChung-Han YangI-Jung ChenKuang-Hui Yu
Myelitis in patients with systemic lupus erythematosus/ Chung-Yuan HsuWen-Chan ChiuTsong-Shing YangChing-Lan ChouYu-Jih SuShan-Fu YuChun-Kai ChiuYing-Chou ChenHan-Ming LaiTien-Tsai ChengChung-Jen Chen
Outcome of lupus nephritis-A 5-year analysis/ Tsong-Shing YangShun-Chen HuangChung-Jen ChenChung-Yuan HsuWen-Chan ChiuChing-Lan ChouFu-Mei SuYu-Jih SuShan-Fu YuChun-Kai ChiuYing-Chou ChenHan-Ming LaiTien-Tsai Cheng
Association of high sensitivity C-reactive protein with hyperuricemia in Taiwanese patients with gout/ Ming-Han ChenWei-Sheng ChenHui-Ting LeeChang-Youh TsaiChung-Tei Chou
Angiopoietin-1 and endoglin are not associated with pulmonary arterial hypertension in patients with systemic lupus erythematous/ Ling-Jung YenHsiu-Man KengChin-Chang ChengJiung-Jun ChuChieh-Mei HsuXin-Tian LinJui-Cheng TsengJui-Chieh HuLing-Ying Lu
Metabolic syndrome in patients with rheumatoid arthritis: association of lifestyle with anthropometric measurements/ Ming-Fu ChenYi-Ming ChenDer-Yuan ChenJoung-Liang Lan
Ruptured Baker's cyst in patients with rheumatic diseases: analysis of 235 Baker's cysts in 198 patients/ Song-Feng YehDeh-Ming ChangJenn-Haung LaiChen-Hung ChenTsung-Yun HouSan-Yuan KuoChi-Sheng ChiouChi-Ching Chang
Clinical and serological features of patients with anti-Jo-1 antibodies/ Ting-Hui ChangSong-Chou HsiehChia-Li Yu
Distinct MHC class Ⅰ and class Ⅱ alleles in Taiwanese patients with ankylosing spondylitis/ Bao-Bao HsuMing-Chi LuKuo-Liang YangKuang-Yung HuangChien-Hsueh TungSu-Qin LiuNing-Sheng Lai
Sonographic findings of Weber Christian disease involving the breasts: a case report/ Kuang-Yung HuangYi-Ming ChenDer-Yuan ChenHsin-Hua Chen
Refractory chylothorax in a patient with systemic lupus erythematosus: case report/ Bao-Bao HsuChien-Hsueh TungMing-Chi LuKuang-Yung HuangNing-Sheng Lai
Multicentric reticulohistiocytosis mimicking rheumatoid arthritis in a 35-year-old woman-case report/ Chyou-Shen LeeMei-Eng TuTien-Ling Chen
"Hide-bound" bowel sign in a patient with progressive systemic sclerosis and chronic intestinal pseudo-obstruction/ Pei-Chen Hsu
 
   
 
   

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