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題名:Adjuvant Treatment with Fish Oil-based Lipid Emulsion for Patients with Septic Shock in Intensive Care Unit: A Clinical Safety Evaluation     (20點)
以深海魚油脂肪乳劑輔助治療敗血性休克重症病患之臨床安全性評估
著者:Boon-Siang Khor(許文祥) ;Sing-Yi Lin(林幸儀) ;Huang-Sheng Chen(陳煥昇) ;Kou-Chou Hsieh(謝國洲) ;Mei-Chih Yeh(葉美枝) ;Ming-Pin Wu(吳銘斌) ;Yih Ting(丁毅) ;How-Chin Liao(廖浩欽) ;Shiumn-Jen Liaw(廖訓禎)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:深海魚油脂肪乳劑 ; 敗血性休克 ; 臨床安全性評估 ; fish oil-based lipid emulsion ; septic shock ; clinical safety evaluations
刊名:Journal of Emergency and Critical Care Medicine
卷期:23卷1期(2012.3)
頁碼:1-10
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:本研究旨在以靜脈輸注深海魚油脂肪乳劑來輔助治療敗血性休克重症病患,探討其臨床安全性。 材料與方法:本研究為前瞻性之臨床研究設計,符合設定條件之敗血性休克病患於入住加護病房24小時內,經由中央靜脈導管輸注深海魚油脂肪乳劑;並記錄病患於治療前與治療後第3、7及14天的意識狀態、肺功能、肝功能、腎功能、凝血功能、血糖值和血脂值之變化。 結果:研究期間,一共有10位病患納入研究分析。病患之意識狀態、肺、肝、腎功能、血糖和血脂值於第3、7及14天時,未有負面影響的統計意義;血小板於第3天時有顯著性的統計意義降低,但於第7和14天時則沒有差異。 結論:本研究結果顯示,靜脈輸注深海魚油脂肪乳劑輔助治療敗血性休克病患的臨床安全性,以提供未來發展深海魚油脂肪乳劑與敗血症之研究者做為參考。
Purpose: The aim of this study was to evaluate the clinical safety of critically ill patients with septic shock who received fish oil-based lipid emulsion (FOBLE) as adjuvant therapy. Materials and Methods: A prospectively study was performed on the patients with septic shock who received a 5-days course of parenteral FOBLE as adjuvant treatment in the ICU. Analyzed variables, including consciousness, pulmonary, liver, renal functions, platelet counts, coagulations, blood sugar and lipid levels, were compared before FOBLE and on days 3, 7, and 14 after FOBLE infusion. Results: Ten patients fulfilled the criteria and were enrolled for analysis. Comparison results disclosed no statistically adverse impact on consciousness, pulmonary, liver, renal functions, coagulations, and blood sugar and lipid levels following on the days 3, 7 and 14. Significant statistically low platelet counts occurred on day 3 (p=0.022), but there were no significant differences on the days 7 and 14. All patients survived in the following 28 days. Conclusions: A 5-day course of parenteral FOBLE as an adjuvant treatment in critically ill patients with septic shock is clinically safe. Our findings provide a valuable safety experiment on additional study with FOBLE in critically septic patients in the future.




本卷期目次
Journal of Emergency and Critical Care Medicine 23卷1期 (2012.3)
Adjuvant Treatment with Fish Oil-based Lipid Emulsion for Patients with Septic Shock in Intensive Care Unit: A Clinical Safety Evaluation/ Boon-Siang KhorSing-Yi LinHuang-Sheng ChenKou-Chou HsiehMei-Chih YehMing-Pin WuYih TingHow-Chin LiaoShiumn-Jen Liaw
Pneumoperitoneum Caused by Ruptured Gas-Containing Pyogenic Liver Abscess: A Case Report and Literature Review/ Chih-Chung ChaoSung-Yuan HuYing-Hock Teng
Spontaneous Pneumomediastinum and Subcutaneous Emphysema after Jogging: Successful Resolution with Conservative Treatment/ Fu-Yuan SiaoWoei-Horng ChaiChun-Wen ChiuChin-Fu ChangChu-Chung ChouChun-Chieh Chiu
Superior Mesenteric Artery Syndrome: A Case Report/ Min-Po HoChang-Ming LiuKaung-Chau TsaiYuan-Hui Wu
Acromegaly with Pituitary Tumor Apoplexy: A Case Report/ Yu-Hsin ChengYi LiuAnn-Shung Lieu
Pneumonia and Acute Respiratory Distress Syndrome in a Patient with Influenza A (H1N1)/ Deng-Wei ChouKuo-Mou Chung
Obturator Hernia with Small Bowel Incarceration/ Min-Chieh ShiehChi-Wen TuChing-Chung ChiangChi-Szu Liao
Ovarian Torsion: An Interesting Plain Abdominal Radiograph of an Ovarian Teratoma/ Jian-Lin OuFang-Shun LinChung-Cheng LeeChiing-Hsiang SuChung-Jen Weng
 
   
 
   

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