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1
題名:PROGNOSTIC FACTORS ANALYSIS OF LUNG CANCER PATIENTS WITH BRAIN METASTASIS AFTER WHOLE BRAIN IRRADIATION     (18點)
肺癌合併腦轉移病患經全腦放射線治療之預後因子分析
著者:Yi-Ting Shih(施怡婷) ;Jin-Ching Lin(林進清) ;Yih-Chyang Weng(翁益強) ;Jian-Sheng Jan(詹建勝)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:肺癌 ; 腦轉移 ; 預後因子 ; 全腦放射線治療 ; Lung cancer ; Brain metastasis ; Prognostic factor ; Whole brain radiotherapy
刊名:Therapeutic Radiology and Oncology
頁碼:265-273
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:肺癌的病人常有腦部轉移的情形發生。這個研究的目的在於評估肺癌合併腦轉移的病患接受全腦放射線治療後的存活結果與預後因子。 材料與方法:從2001年1月到2008年12月,我們回顧共386位肺癌合併腦轉移病患在本院接受全腦放射線治療的結果。終極目標為整體存活期。我們分析了幾個可能的預後因子,包括年齡、性別、病理組織型態、日常體能狀態、腦部轉移數目、先前肺癌治療、放射線劑量和是否有腦部以外的轉移。 結果:沒有人失去聯絡,至今有374個病人因病死亡,另有12個病人仍存活。整體存活期從2週到40個月(中位數4.7個月)。在單變項分析中,年齡小於65歲(p<0.0001)、女性(p<0.0001)、較佳的日常體能狀態(p=0.0201)及無腦部以外的轉移(p=0.0226)的病患有較好的存活率。在多變項分析中,年齡小於65歲(p<0.001)、女性(p<0.001)、較佳的日常體能狀態(p=0.014)、無腦部以外的轉移(p<0.001)及無先前肺癌治療(p=0.003)為較好的預後因子。 結論:肺癌合併腦轉移的病人接受全腦放射線治療的存活結果仍不理想。其中,年輕、女性、較佳的日常體能狀態、無腦部以外的轉移以及無先前肺癌治療為較好的預後因子。
Purpose: Brain metastases occur commonly in patients with lung cancer. The aim of this study is to evaluate survival outcome and prognostic factors of whole brain radiotherapy (WBRT) for lung cancer patients with brain metastases. Patients and Methods: We retrospectively reviewed the medical records of 386 lung cancer patients with brain metastases who received WBRT between January 2001 and December 2008. The end-point was overall survival (OS). Several potential prognostic factors were studied: age, gender, histology, performance status, number of brain metastases, prior therapy of lung cancer, dose schedule, and presence of extracranial metastases. Results: No patient was lost to follow-up. 374 patients died with disease and 12 patients were alive. OS ranged from 2 weeks to 40 months (median 4.7 months). In the univariate analysis, better survival was observed in age <65 years old (p<0.0001), female gender (p<0.0001), good performance status (p=0.0201) and absence of extracranial metastases (p=0.0226). In the multivariate analysis, age<65 years old (p<0.001), female gender (p<0.001), good performance status (p=0.014), absence of extracranial metastases (p<0.001) and absence of prior therapy of lung caner (p=0.003) were favorable factors. Conclusion: The survival outcome for lung cancer patients with brain metastasis after WBRT was poor. Age<65 years old, female gender, good performance status, absence of extracranial metastases and absence of prior therapy of lung caner were favorable prognostic factors.




本卷期目次
Therapeutic Radiology and Oncology
PROGNOSTIC FACTORS ANALYSIS OF LUNG CANCER PATIENTS WITH BRAIN METASTASIS AFTER WHOLE BRAIN IRRADIATION/ Yi-Ting ShihJin-Ching LinYih-Chyang WengJian-Sheng Jan
TREATMENT RESULTS AND PROGNOSTIC FACTORS OF FIGO STAGE III AND IVA CERVICAL CANCER TREATED WITH CONCURRENT CHEMORADIOTHERAPY/ Haw-Harn YangMu-Tai LiuChu-Ping PiTung-Hao ChangChao-Yuan HuangChia-Chun Huang
醫院服務品質與顧客價值對於癌患滿意度的關係探討/ 陳玉萍曾振淦洪志宏曾雁明
肝癌病患營養狀況評估與生活品質之分析/ 許維中詹淑卿陳宇嘉鍾娜娜王博民
A NOVEL VAGINA ENHANCEMENT MODALITY IMPROVES DOSIMETRIC PARAMETERS IN PELVIC INTENSITY-MODULATED RADIOTHERAPY/ John Chun-Hao ChenChao-Hsing WangGwo-Che HuangI-Chun LinWun-Ke ChenPei-San ChiaMeng-Hao WuYu-Jen Chen
準直儀角度對攝護腺癌患者使用銳速刀治療計劃計算結果之影響/ 賴鵬安劉芳慧謝懿葶葉啟源
以電子驗證影像快速估測光與輻射照野一致性、光子平坦性與對稱性/ 陳元柏葉世安吳嘉明陳昱晴丁慧枝
HELICAL TOMOTHERAPY REDUCES PAIN EFFICIENTLY FOR CIRCUITED PLEURAL METASTASIS OF NASOPHARYNGEAL CARCINOMA-A CASE REPORT/ Chen-Hsi HsiehYu-Jen ChenShih-Hua LiuHui-Ju TienLe-Jung WuChien-An ChenLi-Jen LiaoYu-Chin Linand Pei-Wei Shueng
 
   
 
   

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