原名「台灣學術線上」
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1
題名:PREOPERATIVE RADIOTHERAPY CONCURRENT WITH CHEMOTHERAPY FOR LOCALLY ADVANCED RECTAL CANCER     (16點)
直腸癌接受術前同步化學合併放射治療
著者:Yu-Xuan Chen(陳玉瑄) ;William Chen(陳自諒) ;Mu-Tai Liu(劉幕台) ;Chih-Yuang Chung(鐘智淵) ;Cheng-Shyong Chang(張正雄) ;Ger-Hau Hsu(許格豪) ;Hong-Chang Chen(陳宏彰) ;Tung-Hao Chang(張東浩) ;Chu-Ping Pi(畢祖平) ;Chih-Chiech Hsu(許智捷)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:直腸癌 ; 術前化學放射治療 ; Rectal cancer ; Preoperative chemoradiation
刊名:Therapeutic Radiology and Oncology
頁碼:19-26
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

且且:分析局部侵犯性直腸癌病人接受術前同步化學及放射線治療,對腫瘤期別下降和肛門保留的幫助。 材料血?可注:在1 9 99年6月到2 002年2月間,本院共有22名宜腸癌病人接受術前同步化學及放射線治療,再行手術切除。其中包括1 6位男性和6位女性,年齡分佈從28到76歲,年齡中位數6 1歲。化學治療使用高劑量子Fluorourac i l (5-FU) 合併Leucovorin 放射治療中位劑量為50.4Gy (45Gy - 50 .4Gy) 針對骨益腔。放射治療結束後平均6 週( 1 至1 1.7 週) 接受治癒性手術。比較于術後病理期別和治療前臨床期別之間的差異,及肛門保留在這些病人的比例。 益星: 22 位病人中有12 位(55% )有期別下降,其中有三位( 1 4 % )得到完全緩解,在切下組織標本中沒有殘存的腫瘤細胞。另外5位則是病理期別和臨床期別一樣。還有兩位則是治療前評估'k!; Nl '但病理期別顯示N2。有1 8位( 8 2 % )病人施行肛門保留性手術。 益益:術前同步化學及放射線治療再加上手術能有效使腫瘤期別下降,並能使大部分局部晚期宜腸癌病人保留肛門。
Purpose: This study is to present the rates of tumor down-staging and sphincter-preservation with pre-operative concurrent chemo-radiation therapy (CCRT) in locally advanced rectal cancer. Methods and Materials: Between June1999 and February 2002, twenty-two patients with advanced rectal cancer were treated with preoperative CCRT, followed by surgical resection of disease. The patient population consisted of 16 males and 6 females that had a median age of 61 years (range 28 to 76 years). Most of patients received high dose 5-Fluorouracil (5-FU) and Leucovorin, concurrent with pelvic irradiation 50.40Gy(45-50.4 Gy) in 28 fractions over 5.5 weeks. The median interval between completion of radiotherapy and surgery was 6 weeks (range 1- 11.7 weeks). The pre-treatment and post-treatment stages were compared and rates of sphincter preservation were evaluated. Results: Twelve (55%) out of 22 patients achieved tumor downstaging, and 3 (14%) patients had pathologic complete remission. Five patients remained the same stage as pretreatment clinical stage. Two patients had clinical N1 disease but pathologic N2 stage. Sphincter- preserving surgery can achieve in 18(82%) patients. Conclusion: Pre-operative CCRT followed by surgery can be effective for tumor shrinkage, tumor downstaging, and achieving sphincter preservation in most of patients.


    

本卷期目次
Therapeutic Radiology and Oncology
AAPMTG-51號議定書光子與電子劑量計算程式/ 郭力誠鄭秀成游浚彥陳妙芬陳文政
Preperative Radiotherapy Concurrent with Chemotherpy for Locally Advaced Rectal Cancer/ Yu-Xuan ChenWilliamChenMu-Tai LiuChih-Yuang ChungCheng-Shyong ChangGer-Hau HsuHong-Chang ChenTung-Hao ChangChu-Ping PiChih-Chiech Hsu
雙盲對照實驗評估口服pilocarpine對放射線治療引起頭頸部癌症病患口乾症於馬偕醫院之使用主觀效果及安全性報告/ 陳舜鼎張國華陳裕仁鍾昌宏吳孟浩蘇文浩陳虹汶賴允亮
Preoperative Radiotherapy and Chemotherapy for Low or Locally Advaced Rectal Cancer/ I-Chun YehHelen H.W. ChenJeng-Chang LeeWu-Chou SuHong-Ming TsaiHenry W.C. Leung
改良式軟片劑量驗證應用於強度調控放射線治療之先期研究/ 蔡忠宏莊克士戴宏旗周志成蕭安成林芳仁
Definitive Radiotherapy for the Patients with Prostatic Adenocarcinoma: Analysis of Short-Term Outcome and Prognostic Factors/ Shena Yu-Hsuan ChenJason Chia-Hsien ChengStella Y. TsaiSkye Hon-Giun ChengDaniel S. ChangAlex Lien-Yen YangJames Jer-Min Jian
固定深度治療對直腸肛門癌放射治療的影響/ 曾雁明范綱行白冰清蔡介生林倩伃陳臣苑曾振淦
DEFINITIVE RADIOTHERAPY FOR THE PATIENTS WITH PROSTATIC ADENOCARCINOMA: ANALYSIS OF SHORT-TERM OUTCOME AND PROGNOSTIC FACTORS/ Shena Yu-Hsuan ChenJason Chia-Hsien ChengStella Y TsaiSkye Hongiun ChengDaniel S ChangAlex Lien-Yen YangJames Jer-Min Jian
雙盲對照實驗評估口服pilocarpine對放射線治療引起頭頸部癌症病患口乾症於馬偕醫院之使用主觀效果及安全性報告/ 陳舜鼎張國華陳裕仁鍾昌宏吳孟浩蘇文浩陳虹汶賴允亮
PREOPERATIVE RADIOTHERAPY CONCURRENT WITH CHEMOTHERAPY FOR LOCALLY ADVANCED RECTAL CANCER/ Yu-Xuan ChenWilliam ChenMu-Tai LiuChih-Yuang ChungCheng-Shyong ChangGer-Hau HsuHong-Chang ChenTung-Hao ChangChu-Ping PiChih-Chiech Hsu
PREOPERATIVE RADIOTHERAPY AND CHEMOTHERAPY FOR LOW OR LOCALLY ADVANCED RECTAL CANCER/ I-Chun YehHelen H. W. ChenJeng-Chang LeeWu-Chou SuHong-Ming TsaiHenry W. C. Leung
固定深度治療對直腸肛門癌放射治療的影響/ 曾雁明范綱行白冰清蔡介生林倩?陳臣苑曾振淦
AAPMTG-51號議定書光子與電子劑量計算程式/ 郭力誠鄭秀成游浚彥陳妙芬陳文政
改良式軟片劑量驗證應用於強度調控放射線治療之先期研究/ 蔡忠宏莊克士戴宏旗周志成蕭安成林芳仁
 
   
 
   

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