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題名:鼻咽癌病患接受體外放射治療-局部治療劑量4500cGy以下結果之探討     (12點)
THE OUTCOME OF PATIENTS WITH NASOPHARYMGEAL CARCINOMA TREATED WITH SUBOPTIMAL RADIATION DOSE
著者:黃意婷(Yi-Ting Huang) ;白冰清(Ping-Ching Pai) ;曾振淦(Chen-Kan Tseng) ;林倩?(Chien-Yu Lin) ;洪志宏(Ji-Hong Hong) ;曾雁明(Ngan-Ming Tsang)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:鼻咽癌 ; 放射治療 ; 治療劑量不足 ; Undertreatment ; Nasopharyngeal carcinoma ; Radiotherapy
刊名:放射治療與腫瘤學
頁碼:63-68
語言:繁體中文
摘要: 中文摘要PDF ; 英文摘要PDF

旦的: 本研究之目的在分析鼻睏癌病患接受體夕材生射線治療, 但局部治療劑量在4 5 0 0 cGy 下之情形。 組組舉主主主:從1 9 79年4月至1 9 97年1 2月,共有1 3 8位鼻睏癌病患在林口長庚醫院接受體外放射治療劑量4 5 0 0 cGy 以下, 且之後並未於他院接受放射線治療或化學治療等Q 其中男性103人、女性3 5人, 年齡分布於1 8歲至8 5歲之間,身咽的治療劑量介於1 80 cG y 至450 0 cGy間,中位劑量( median dose ) 為2 5 2 0 d3 y 0 使用K a pl a n- Me ie r 之方法來決定其生存期。 越是:這1 3 8位病人自說皂蹤期間從3年至1 4 .7年不等,其追蹤之中位數為7 . 1年。直至20 0 1年12 月底止, 仍存活者共有7 人, 其中5 人是無庸字活; 130 人己死亡, 而其中77 人(56 % ) 死於局部腫瘤, 38 人(27 .5% ) 死於遠處車輛事, 14 人( 10% ) 死於惡病質, 1 (0 .7% ) 人死於腦中風1人失去聯絡。年及五年之整體存活率分別為52 %及1 1 % ;中位存活期為1 . 06年,而大部分之病人都於中斷治療後2年內死亡。 益益:研究串在果顯示鼻咽吉病患接受L局部放射治療劑量只有45 0 0 cGy 以下者其預後是很差的, 大部分病患於治療中斷後之2年內死亡,而造成病患治療中斷主要導因乃是病患無法忍受放射治療所引尪急性副作用之故。
Purpose : To study the outcome of undertreated nasopharyngeal carcinomas (NPC) in patients who received external beam radiation doses of no more than 4500 cGy. Materials and Methods : From April 1979 to December 1997, 138 NPC patients receiving radiotherapy with external beam radiation (EBRT) doses of no more than 4500 cGy at the Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, were included in this study. Total doses ranged from 180 cGy to 4500 cGy with a median dose of 2520 cGy. The survivals were calculated by Kaplan- Meier method. The median follow-up time was 7 years. Results : At the time of last follow-up, the 1- and 5-year survival rates for the 138 undertreated NPC patients, derived using the Kaplan-Miere method, were 52% and 11%, respectively. One hundred and twenty-nine patients had died of the disease. One patient had died of intercurrent disease. Five patients were alive without disease. Two patients were alive with disease. One patient was loss of follow-up. The median survival of these patients was 1.06 years (range from 0.03 ~ 19.7 year). At the end of study, local recurrent or persistent tumors were determined for 94 patients (68%). Forty-nine patients (35.5%) subsequently developed distant metastases. The causes of death were: locoregional disease: 56% (n = 77), distant metastasis: 27.5% (n = 38), cachexia: 11% (n = 15), cerebrovascular accident: 0.7% (n = 1). Bone, liver and lung were the most common metastatic sites. Most of the patients died within two years after interruption of treatments. Death was the only outcome evaluated. Less than 5% patients (n = 5) were alive without disease till the time of analysis. Discussion : The prognosis has been dismal for undertreated NPC patients. Our study confirmed that long-term survival is rare in patients with NPC receiving EBRT doses not more than 4500 cGy. The majority of patients died within 2 years after interruption of radiotherapy (RT). The acute side effects and complications of RT were the primary factors influencing the patient’s decisions to drop out of the treatment.


    

本卷期目次
放射治療與腫瘤學
RADIOTHERAPY OF GERM CELL TUMOR IN BASAL GANGLION:CASE REPORT AND REVIEW OF LITERATURE/ Hui-Ling YehJian-Sheng Jan
高密度金屬物質在直線加速器放射治療之劑量擾動效應的蒙地卡羅模擬/ 張柏菁李宗其許任玓葉健一陳俊丞徐椿壽
鼻咽癌病患接受體外放射治療─局部治療劑量4500cGy以下結果之探討/ 黃意婷白冰清曾振淦林倩伃洪志宏曾雁明
RADIOTHERAPY FOR EXTRAMAMMARY PAGET'S DISEASE OF THE VULVA:REPORT OF TWO CASESsease of the vulva:report of two cases/ Ming-Wei YangHelen H.W.ChenJulia Yu-Yun LeeSheau-Chiou ChaoHenry W.C.Leung
188Re液體貝他射源於血管近接治療之劑量評估與量測技術/ 林威廷羅崇功朱健豪謝柏滄黃文松
淬取大腦影像正中矢狀切面進行三維電腦斷層與磁振造影的對準與融合/ 周銘鐘蕭正英陳志成
THREE DIMENSIONAL CONFORMAL RADIOTHERAPY FOR PORTAL VEIN TUMOR THOMBOSIS IN ADVANCED HEPATOCELLULAR CARCINOMA/ Chien-Ru LiuChih-Lin LinLi-Ying LiaoHsing-Yang TuChi-Fu HungChaur-Shine WangJyh-Der Leu
RADIOTHERAPY FOR EXTRAMAMMARY PAGET'S DISEASE OF THE VULVA: REPORT OF TWO CASES/ Ming-Wei YangHelen H. W. ChenJulia Yu-Yun LeeSheau-Chiou ChaoHenry W. C. Leung
RADIOTHERAPY OF GERM CELL TUMOR IN BASAL GANGLION: CASE REPORT AND REVIEW OF LITERATURE/ Hui-Ling YehJian-Sheng Jan
鼻咽癌病患接受體外放射治療-局部治療劑量4500cGy以下結果之探討/ 黃意婷白冰清曾振淦林倩?洪志宏曾雁明
THREE DIMENSIONAL CONFORMAL RADIOTHERAPY FOR PORTAL VEIN TUMOR THROMBOSIS IN ADVANCED HEPATOCELLULAR CARCINOMA/ Chien-Ru LiuChih-Lin LinLi-Ying LiaoHsing-Yang TuChi-Fu HungChaur-Shine WangJyh-Der Leu
高密度金屬物質在直線加速器放射治療之劑量擾動效應的蒙地卡羅模擬/ 張柏菁李宗其許任玓葉健一陳俊丞徐椿壽
淬取大腦影像正中矢狀切面進行三維電腦斷層與磁振造影的對準與融合/ 周銘鐘蕭正英陳志成
188Re液體貝他射源於血管近接治療之劑量評估與量測技術/ 林威廷羅崇功朱健豪謝柏滄黃文松
 
   
 
   

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