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1
題名:肝癌患者接受立體定位放射線治療期間疲倦及血液數值變化之探討     (24點)
EVALUATION OF THE CHANGES OF FATIGUE AND HEMATOLOGY INDEX LEVEL IN HEPATOCELLULAR CANCER PATIENTS RECEIVING STEREOTACTIC RADIATION THERAPY
著者:蕭雅莉(Ya-Li Hsiao) ;賴裕和(Yeur-Hur Lai) ;邱仲峰(Jeng-Fong Chiou) ;蔡若婷(Jo-Ting Tsai) ;葉啟源(Chi-Yuan Yeh) ;鍾道生(Tao-Sang Chung) ;高仲瑜(Chung-Yu Kao) ;林美良(Meei-Liang Lin)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:立體定位放射線治療 ; 疲倦 ; 血液數值 ; Stereotactic radiotherapy ; Fatigue ; Laboratory data
刊名:放射治療與腫瘤學
頁碼:197-208
語言:繁體中文
摘要: 中文摘要PDF ; 英文摘要PDF

旦的: 在台灣, 肝癌是常見的惡性腫瘤, 近年來立體定位放射線治療是治療肝癌的新方式之一。對於治療期間病患所出現的疲倦問題,目前尚未有研究探討,因此本研究主要探討肝癌患者在接受肝臟重瘤立體定位放射線治療期間所產生的疲{觀度及血河蠍值之變化。 姐姐盟主法: 本研究採前瞻性縱貫式研究設計, 1i~北市三fiJi教學醫院取樣收案,收案時間自民國9 0 年12 月至91 年5 月間, 共收集45 位符合條件之肝癌患者為收案對象, 其中5 位患者分別因死亡或中途退出而中止訪談,故完PXi.連續七週研究渚共計40名;每週以疲倦症狀量表進行疲倦強度、持續時間及對生活平擾程度之測量。血液數值方面每週進行H b 、H t、WB C及P i a te l et 之檢驗,共言十七次;此外分別於放射治療治療前一週、放射治療中第二、四及第六週來追蹤A S T、A L T 及A lb u mi n 之變化。統計方位t SPSS 套裝軟體進行資料分析。 益墨: 所有研究對象於立體定位放射治療前tW存在疲倦現象, 除第三週略為改善外, 疲倦程度於第五週達高峙,第六週便改善( p < 0.0 1 ) , 但整f固、台療期間疲倦租支仍屬輕度範圍。研究對象於治療前一週的血液學數值除H t偏低外,其他數值皆在正常範圍內,但經放射治療後, Hb 、Ht 、WBC 、p l a te l et 隨放射治療而逐漸下降( p < 0.05 ) ,且皆低於正常值。此外, 治療前患者之A S T 、A L T數值皆高,且隨治樹豪程而持續升高,於第六週達高峰; A lb u mi n 數值貝I) 隨放射治療療程而逐漸下降( p < 0 .0 1) ' 但治療前後均處於正常範圍內。而疲f禮拜呈度的高低與血液數值(WBC 、P l a te 蚓、AST、A L T 及A l bu mi n ) 之間並無顯著相關( p > 0 . 05 ) 。 站站:雖然疲倦是肝癌患者於接受立體定位放射線治療期間常見的問題,但所呈現的程度屬輕度範圍, 而血液中代表肝功能之生化數值會隨治療療程部分有改變。本研究結果可提供臨床醫療人員在照護此類病,害時有更多的參考訊息,適時提性相關醫護處置,以協it!]!青患渡過才有直的階段。
Purpose : Hepatocellular carcinoma is a common malignancy in Taiwan. Recently, stereotactic radiotherapy is one of the new treatment modality for this disease. However, there still do not have study focused on the changes of fatigue level in patients receiving this treatment. The purpose of this study was to evaluate the changes of fatigue and hematology index in hepatocellular cancer patients receiving stereotactic radiotherapy. Materials and methods : Prospective longitudinal research design was developed to examine the changes of fatigue and hematology index during and after stereotactic radiotherapy. Data were collected from December 2001 to May 2002. A total of 45 eligible subjects were recruited from two teaching hospitals in Taipei. Five patients were excluded due to expire or dropout from this study. Forty eligible patients finished the seven weeks study. Fatigues index were evaluated by questionnaire of Fatigue Symptom Inventory (FSI) which measured the fatigue intensity, fatigue duration and fatigue interference weekly. Hb, Ht, WBC and Platelet were measured weekly for 7 weeks. Besides, AST, ALT and albumin blood index were measured one week before radiation therapy and at week 2, week 4 and week 6 during treatment. Data were analyzed by SPSS computer program. Results : All the subjects in this study had mild fatigue in the beginning of the treatment. Their fatigue intensity, fatigue duration and fatigue interference were significantly increased from pre-treatment to the 5th week except the 3rd week. The peak level of fatigue occurred in the 5th week and it decreased since the 6th week (p < 0.01). Blood Hb, Ht, WBC and platelet level descended gradually to abnormal along with treatment (p < 0.05), but the blood AST and ALT level rise along with the treatment. Though the blood albumin level decreased, it was in normal range. Nonsignificant correlations between fatigue level and laboratory data were found. Conclusion : Fatigue was a commonly experienced problem in hepatocellular cancer patients receiving stereotactic radiotherapy, but the fatigue scores were at minimal level. Part of the hematology study data change during treatment. The results of this study can provide the clinical personnel information about the change of fatigue level in hepatocellular cancer patients receiving stereotactic radiotherapy


    

本卷期目次
放射治療與腫瘤學
單管圓柱狀近接裝療器劑量分佈最佳化的影響因素/ 李政橋蔡介生黃英強李俊德傅定國李文翰羅慶榮
肝癌患者接受立體定位放射線治療期間疲倦及血液數值變化之探討/ 蕭雅莉賴裕和邱仲峰蔡若婷葉啟源鍾道生高仲瑜林美良
Treatment Results of Tongue Cancer in Patient Younger than 40 Years Old/ Kang-Hsing FanChen-Kan TsengPing-Ching PaiNgan-Ming TsangJi-Hong Hong
在不同深度下量測電子射束之有效射源-表面距離以運用於臨床/ 張秀淘白淑珍葛迺玟鄭秀成
以迷你豬作為腮腺輻射反應研究之模式及初步結果/ 任益民蘇萬福林曜祥劉岱瑋趙興隆張俊梁林宏益林群書岑榮潤
Brain Necrosis as a Consequence of Reirradiation in Meningeal Hemangiopericytoma: A Case Report and Review of the Literature/ Suzun ShawJing-Shan HuangShih-Hung HuangYung-Chien HuangChin-Ming JengChing-Jung Wu
Preliminary Results of Three-Dimensional Conformal Radiotherapy and Thalidomide for Advanced Hepatocellular Carcinoma/ Po-Ming WangWei-Chung HsuSue-Ching ChanNa-Na ChungLai-Lei TingKung-Shih YingChe-Jen ChaoGau-De Lin
Is Melanin a Radioprotector or Radiosensitizer? It’s Implication for Radiotherapy/ Wen-Lin HsuJing-Min HwangDai-Wei LiuYee-Min JenChien-Yuan Chen
Concurrent Chemoradiation with Weekly Cisplatin plus Systemic Adjuvant Chemotherapy for Locally Advanced Esophageal Cancer: A Pilot Study/ Shih-Kai HungHung-Chang LiuKuo-Hwa ChangYuen-Liang LaiCharng-Jer HuangYu-Jen Chen
以迷你豬作?腮腺輻射反應研究之模式及初步結果/ 任益民蘇萬福林曜祥劉岱瑋趙興隆張俊梁林宏益林群書岑榮潤
肝癌患者接受立體定位放射線治療期間疲倦及血液數值變化之探討/ 蕭雅莉賴裕和邱仲峰蔡若婷葉啟源鍾道生高仲瑜林美良
PRELIMINARY RESULTS OF THREE-DIMENSIONAL CONFORMAL RADIOTHERAPY AND THALIDOMIDE FOR ADVANCED HEPATOCELLULAR CARCINOMA/ Po-Ming WangWei-Chung HsuSue-Ching ChanNa-Na ChungLai-Lei TingKung-Shih YingChe-Jen ChaoGau-De Lin
TREATMENT RESULTS OF TONGUE CANCER IN PATIENT YOUNGER THAN 40 YEARS OLD/ Kang-Hsing FanChen-Kan TsengPing-Ching PaiNgan-Ming TsangJi-Hong Hong
CONCURRENT CHEMORADIATION WITH WEEKLY CISPLATIN PLUS SYSTEMIC ADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED ESOPHAGEAL CANCER-A PILOT STUDY/ Shih-Kai HungHung-Chang LiuKuo-Hwa ChangYuen-Liang LaiCharng-Jer HuangYu-Jen Chen
IS MELANIN A RADIOPROTECTOR OR RADIOSENSITIZER? IT'S IMPLICATION FOR RADIOTHERAPY/ Wen-Lin HsuJing-Min HwangDai-Wei LiuYee-Min JenChien-Yuan Chen
在不同深度下量測電子射束之有效射源-表面距離以運用於臨床/ 張秀淘白淑珍葛迺玟鄭秀成
單管圓柱狀近接裝療器劑量分佈最佳化的影響因素/ 李政橋蔡介生黃英強李俊德傅定國李文翰羅慶榮
BRAIN NECROSIS AS A CONSEQUENCE OF REIRRADIATION IN MENINGEAL HEMANGIOPERICYTOMA: A CASE REPORT AND REVIEW OF THE LITERATURE/ Su-Zun ShawJing-Shan HuangShih-Hung HuangYung-Chien HuangChin-Ming JengChing-Jung Wu
放射治療與腫瘤學第八至十卷作者姓名索引
Subject index of volume 8-10 of Therapeutic Radiology and Oncology
 
   
 
   

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