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1
題名:IS MELANIN A RADIOPROTECTOR OR RADIOSENSITIZER? IT'S IMPLICATION FOR RADIOTHERAPY     (20點)
黑色素是輻射保護劑或輻射致敏劑?及其在放射治療上的運用
著者:Wen-Lin Hsu(許文林) ;Jing-Min Hwang(黃經民) ;Dai-Wei Liu(劉岱瑋) ;Yee-Min Jen(任益民) ;Chien-Yuan Chen(陳建源)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:黑色素 ; 輻射保護劑 ; 輻射致敏劑 ; 放射治療 ; 惡性黑色素瘤 ; Eumelanin ; Pheomelanin ; Radioprotector ; Radiosensitizer ; Radiotherapy ; Malignant melanoma
刊名:Therapeutic Radiology and Oncology
頁碼:237-246
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

黑色素對於人類皮膚細胞是光照保護劑( Photoprotector )或光照致敏劑(Photosensitizer ) ,長久以來仍存有許多爭議。流行病學的研究顯示:深膚色人種與白種人相較,因紫外線引發皮膚損傷,包括黑色素瘤或其他皮膚腫瘤的機會較少。然而,過去的研究也發現:黑色素及其中間產物與前驅物在接受紫外線照射後會產生反應性氧化物質( re ac t i ve - o x y g e n species ) , 因此顯示黑色素也是有效的光照致敏劑。 經過十年來不斷創新與前所未有的研究,使我們更加擴展對黑色素的認知與瞭解。黑色素是由酥胺酸( ty ro s i n e )氧化所形成之單元體所建構之高度不規則異化之聚合物,其包含兩種構型e u me l an i n 及p h e ome l a n i n 0 目前證實e ume l a n i n 是具有光照保護效果的色素, 而ph e o melanin在紫外線照射後會產生細胞毒性。 黑色素與游離輻射也存在有類似的效應﹒ e u me l a n in不僅有光照保護效果,同時也有輻射保護效果,這與臨床上所觀察到惡性黑色素瘤細胞之輻射抵抗性的現象相符合。因此若能阻斷eumelanin 色素的合成過程, 對於增進惡性黑色素瘤的放射治療效果當有潛在的意義。
It continues to be debated whether melanins are photoprotecting or photosensitizing in human skin cells. Epidemiologic studies have demonstrated that dark-skinned people are much less susceptible than Caucasians to ultraviolet (UV)-induced skin damage including both non-melanoma and melanoma skin cancer. On the other hand, melanin, its intermediates and precursors can generate reactive-oxygen species when irradiated with UV irradiation and have been shown to be effective photosensitizers. The last decade has witnessed a renewed and unprecedented impetus in melanin research that has significantly expanded our knowledge of this field. Melanin is a highly irregular heteropolymer consisting of monomeric units derived from the enzymatic oxida- tion of the amino acid tyrosine. There are two distinct types of melanin, eumelanin and pheomelanin. Now, it is proved that eumelanins are the main photoprotective pigment in the epidermis and pheomelanins are phototoxic upon irradiation. The same situation is also true for ionizing radiation that eumelanin not only pos- sesses radiation protective effect but also contains photoprotective ability. Since malig- nant melanoma is resistant to radiation therapy, therapeutic strategies targeted to the melanogenesis of eumelanin may have potential benefit for the radiation therapy of malignant melanoma.


    

本卷期目次
Therapeutic Radiology and Oncology
肝癌患者接受立體定位放射線治療期間疲倦及血液數值變化之探討/ 蕭雅莉賴裕和邱仲峰蔡若婷葉啟源鍾道生高仲瑜林美良
Preliminary Results of Three-Dimensional Conformal Radiotherapy and Thalidomide for Advanced Hepatocellular Carcinoma/ Po-Ming WangWei-Chung HsuSue-Ching ChanNa-Na ChungLai-Lei TingKung-Shih YingChe-Jen ChaoGau-De Lin
Treatment Results of Tongue Cancer in Patient Younger than 40 Years Old/ Kang-Hsing FanChen-Kan TsengPing-Ching PaiNgan-Ming TsangJi-Hong Hong
在不同深度下量測電子射束之有效射源-表面距離以運用於臨床/ 張秀淘白淑珍葛迺玟鄭秀成
Is Melanin a Radioprotector or Radiosensitizer? It’s Implication for Radiotherapy/ Wen-Lin HsuJing-Min HwangDai-Wei LiuYee-Min JenChien-Yuan Chen
Concurrent Chemoradiation with Weekly Cisplatin plus Systemic Adjuvant Chemotherapy for Locally Advanced Esophageal Cancer: A Pilot Study/ Shih-Kai HungHung-Chang LiuKuo-Hwa ChangYuen-Liang LaiCharng-Jer HuangYu-Jen Chen
以迷你豬作為腮腺輻射反應研究之模式及初步結果/ 任益民蘇萬福林曜祥劉岱瑋趙興隆張俊梁林宏益林群書岑榮潤
Brain Necrosis as a Consequence of Reirradiation in Meningeal Hemangiopericytoma: A Case Report and Review of the Literature/ Suzun ShawJing-Shan HuangShih-Hung HuangYung-Chien HuangChin-Ming JengChing-Jung Wu
單管圓柱狀近接裝療器劑量分佈最佳化的影響因素/ 李政橋蔡介生黃英強李俊德傅定國李文翰羅慶榮
以迷你豬作?腮腺輻射反應研究之模式及初步結果/ 任益民蘇萬福林曜祥劉岱瑋趙興隆張俊梁林宏益林群書岑榮潤
肝癌患者接受立體定位放射線治療期間疲倦及血液數值變化之探討/ 蕭雅莉賴裕和邱仲峰蔡若婷葉啟源鍾道生高仲瑜林美良
PRELIMINARY RESULTS OF THREE-DIMENSIONAL CONFORMAL RADIOTHERAPY AND THALIDOMIDE FOR ADVANCED HEPATOCELLULAR CARCINOMA/ Po-Ming WangWei-Chung HsuSue-Ching ChanNa-Na ChungLai-Lei TingKung-Shih YingChe-Jen ChaoGau-De Lin
TREATMENT RESULTS OF TONGUE CANCER IN PATIENT YOUNGER THAN 40 YEARS OLD/ Kang-Hsing FanChen-Kan TsengPing-Ching PaiNgan-Ming TsangJi-Hong Hong
CONCURRENT CHEMORADIATION WITH WEEKLY CISPLATIN PLUS SYSTEMIC ADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED ESOPHAGEAL CANCER-A PILOT STUDY/ Shih-Kai HungHung-Chang LiuKuo-Hwa ChangYuen-Liang LaiCharng-Jer HuangYu-Jen Chen
IS MELANIN A RADIOPROTECTOR OR RADIOSENSITIZER? IT'S IMPLICATION FOR RADIOTHERAPY/ Wen-Lin HsuJing-Min HwangDai-Wei LiuYee-Min JenChien-Yuan Chen
在不同深度下量測電子射束之有效射源-表面距離以運用於臨床/ 張秀淘白淑珍葛迺玟鄭秀成
單管圓柱狀近接裝療器劑量分佈最佳化的影響因素/ 李政橋蔡介生黃英強李俊德傅定國李文翰羅慶榮
BRAIN NECROSIS AS A CONSEQUENCE OF REIRRADIATION IN MENINGEAL HEMANGIOPERICYTOMA: A CASE REPORT AND REVIEW OF THE LITERATURE/ Su-Zun ShawJing-Shan HuangShih-Hung HuangYung-Chien HuangChin-Ming JengChing-Jung Wu
放射治療與腫瘤學第八至十卷作者姓名索引
Subject index of volume 8-10 of Therapeutic Radiology and Oncology
 
   
 
   

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