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題名:CONCURRENT WEEKLY CISPLATIN AND RADIOTHERAPY PLUS ADJUVANT CHEMOTHERAPY FOR NASOPHARYNGEAL CANCER-A PRELIMINARY STUDY     (14點)
同步每週給予cisplatin合併放射線治療加上輔助性化學治療對於鼻咽癌作用的初步研究結果
著者:Chien-An Chen(陳建安) ;Kou-Hwa Chang(張國華) ;Yi-Shing Leu(呂宜興) ;Jehn-Chuan Lee(李振川) ;Yuen-Liang Lai(賴允亮) ;Eu-Jun Chen(陳昱君) ;Chang-Hung Chung(鍾昌宏) ;Yu-Jen Chen(陳裕仁)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:鼻咽癌 ; 同步化學放射治療 ; 輔助性化療 ; Nasopharyngeal carcinoma ; Concurrent chemoradiotherapy ; Adjuvant chemotherapy
刊名:Therapeutic Radiology and Oncology
頁碼:9-15
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

且且:已有研究顯示在局部晚期的鼻咽癌病患中, 接受同步化學放射線治療者比單純接受放射線治療者有較好的存活率。為了強化放射線的效果,同時減少化學治療引起的毒性,我們使用位劑量的c i s p l at i n 作為同步化學放射線治療的藥物並評估其功效與毒性。 主法: 共有1 4 個符合條件的病患接受原發部位7 0 ~ 72 Gy 的遠隔及3 .5 Gy 的腔內放射組治療,同時每週給予一次低劑量的c i sp l atin ( 30 mg/m2) , 共7 至U 8 週: 在同步化學放射線治療之後給予4次的輔助性化學治療,每次每個月注射CDDP 20 mg/m2/day 和5-FU 1000 mg/m2/24hs 連續注射5天, 並分析腫瘤反應與毒性。 結果: II 位病患在8 ~ 1 0 週之間, 3 位延後至I I j1§J 完成同步化學放射線治療, 一半的病患接受完整4 週期的輔助性化學治療。1 0 個病患( 7 1 .4%) 在完成同步化學放射治療後有完全反應,另外三個在接受完整個治療計劃' 包含同步化學放射治療與輔助性化療後達到完全反應。在同步化學放射治療期間, 3 個病人(2 1.4 % ) 有3 或4 級的口咽黏膜炎, 8 個病人(57.1 %)有3或4級的放射性皮膚炎; 在這個治療中, 沒有發生嚴重的腎臟或致命的毒性。在1 9 . 5 個月的中位數追蹤期中, I 個病患仍有殘餘腫瘤, 1 個復發, 2 個有全身性轉移。 結論: 同步化學放射線治療配台輔助性化療的治療計劃對於鼻咽癌病患有助益, 且其急性毒性是可接受而且是可回復的,這種治療計劃的初步結果值得進一步用隨機分派的臨床計劃證實之。
Purpose : It has been shown that concurrent chemoradiotherapy (CCRT) confers significantly better survival in locally advanced nasopharyngeal carcinoma (NPC) compared with radiotherapy. We conducted a prospective pilot study to evaluate the efficacy and toxicity of a CCRT regimen using low-dose cisplatin (CDDP) for treatment of NPC to see if it enhanced radiation response and reduced chemotherapy-induced toxicity. Materials and Methods : A total of 14 patients were enrolled. The CCRT regimen consisted of radiotherapy (RT), 70~72 Gy to the primary tumor with concurrent CDDP 30 mg/m2 administered once a week for 7 to 8 weekly doses. After CCRT, 4 cycles of adjuvant CDDP, 20 mg/m2/day, and 5-FU, 1000 mg/m2 infused over 24 hours for 5 consecutive days were given monthly. Tumor response and toxicity were analyzed. Results : Eleven patients completed CCRT in 8 to 10 weeks, 3 patients delayed up to eleven weeks, and half (50%) received 4 complete courses of adjuvant chemotherapy. Ten (71.4%) patients had a complete response (CR) after CCRT, with an additional 3 achieving a CR after adjuvant chemotherapy, for a total of 13 (92.9%) out of 14. Adverse effects of CCRT included grade 3 or 4 oropharyngeal mucositis in 3 (21.4%) and grade 3 or 4 radiation dermatitis in 8 (57.1%). There was no severe renal or fatal toxicity from the treatment. At a median follow-up of 19.5 months, 1 patient still had residual tumor, 1 had recurrence and 2 had systemic metastases. Conclusion : CCRT followed by adjuvant chemotherapy was effective in a small series of NPC patients, with acceptable and reversible acute toxicity. This protocol deserves further investigation in randomized prospective trials


    

本卷期目次
Therapeutic Radiology and Oncology
Primary Tracheal Malignancy: Our Experience / Weir-Chiang YouJian-Sheng JanJin-Ching LinYih-Chyang Weng
Spinal Cord Drop Metastasis of Intracranial Oligodendroglioma: A Case Report/ Shih-Tshung ChangWen-Shan Liu
Primary Central Nervous System Fibrosarcoma: Case Report and Literature Review / Forn-Chia LinJsung-Chia TsiaChang-Chuan SuChung-Ching ChioLi-Ching Lin
Primary Central Nervous System Lymphoma: A Meta-Analysis Study / Cheng-Hong LiouMu-Tai LiuShi-Hai LTung-Hao ChangChu-Ping PiChao-Yuan HuangAi-Yih WangChih-Chieh Hsu
乳房乳管原位癌患者接受乳房保留手術合併放射線治療:預後因子分析 / 黃家俊劉幕台張東浩畢祖平
應用於放射治療之自動食道邊緣分割演算法 / 范佩華李宗其許靖涵
Recurrent Pigmented Villonodular Synovitis of Knee Treated with Surgery and Adjuvant Radiotherapy: A Case Report/ Yu-Chang LiuYu-Jen ChenYung-Chang LuChang-Hung Chung
鼻咽癌使用強度調控放射治療影響耳下腺功能的因子/ 劉文山蘇茂昌辛宗翰李永康周希諴郭祥吉
Concurrent Weekly Cisplatin and Radiotherapy Plus Adjuvant Chemotherapy for Nasopharyngeal Cancer –A Preliminary Study / Chien-An ChenKou-Hwa ChangYi-Shing LeuJehn-Chuan LeeYuen-Liang LaiEu-Jun ChenChang-Hung ChungYu-Jen Chen
鼻咽癌使用強度調控放射治療影響耳下腺功能的因子/ 劉文山蘇茂昌辛宗翰李永康周希諴郭祥吉
乳房乳管原位癌患者接受乳房保留手術合併放射線治療:預後因子分析/ 黃家俊劉幕台張東浩畢祖平
PRIMARY TRACHEAL MALIGNANCY: OUR EXPERIENCE/ Weir-Chiang YouJian-Sheng JanJin-Ching LinYih-Chyang Weng
PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA: A META-ANALYSIS STUDY/ Cheng-Hong LiouMu-Tai LiuShi-Hai LiTung-Hao ChangChu-Ping PiChao-Yuan HuangAi-Yih WangChih-Chieh Hsu
應用於放射治療之自動食道邊緣分割演算法/ 范佩華李宗其許靖涵
RECURRENT PIGMENTED VILLONODULAR SYNOVITIS OF KNEE TREATED WITH SURGERY AND ADJUVANT RADIOTHERAPY: A CASE REPORT/ Yu-Chang LiuYu-Jen ChenYung-Chang LuChang-Hung Chung
PRIMARY CENTRAL NERVOUS SYSTEM FIBROSARCOMA: CASE REPORT AND LITERATURE REVIEW/ Forn-Chia LinJsung-Chia TsiaChang-Chuan SuChung-Ching ChioLi-Ching Lin
SPINAL CORD DROP METASTASIS OF INTRACRANIAL OLIGODENDROGLIOMA: A CASE REPORT/ Shih-Tshung ChangWen-Shan Liu
CONCURRENT WEEKLY CISPLATIN AND RADIOTHERAPY PLUS ADJUVANT CHEMOTHERAPY FOR NASOPHARYNGEAL CANCER-A PRELIMINARY STUDY/ Chien-An ChenKou-Hwa ChangYi-Shing LeuJehn-Chuan LeeYuen-Liang LaiEu-Jun ChenChang-Hung ChungYu-Jen Chen
 
   
 
   

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