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1
題名:TREATMENT RESULTS OF LANGERHANS CELL HISTIOCYTOSIS: A LONG TERM FOLLOW-UP     (16點)
蘭格漢氏組織細胞增多症的治療結果:長期追蹤
著者:Chun-Shu Lin(林群書) ;Jing-Min Hwang(黃經民) ;Yee-Min Jen(任益民) ;Yi-Jen Peng(彭奕仁) ;Li-Ping Chang(張立平) ;Hsing-Lung Chao(趙興隆) ;Dai-Wei Liu(劉岱瑋) ;Hon-Yi Lin(林宏益) ;Weng-Yoon Shum(岑榮潤)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:蘭格漢氏組織細胞增多症 ; 組織細胞增多症X ; Langerhans cell histiocytosis ; Histiocytosis X
刊名:Therapeutic Radiology and Oncology
頁碼:185-192
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

且且: 研究蘭格漢氏組織細胞增多症患者治療後的長期追蹤結果。 材料與于守法: 自1 9 7 8 年l 月至2 0 0 2 年1 2 月止, 共有2 0 位蘭格漢氏組織細胞增多症患者於三軍總醫院接受治療。患者年齡的中位值為1 2歲。治療方法包括手術、化學治療、放射治療、台併多種治療方式及觀察。追蹤時間的中位值為87個月。 鎧星: 五年的整體存活率及無疾病進展存活率分別為10 0 % 及9 2 % 。五年無疾病進展存活率在接受放射治療及沒有接受放射治療的病人中,分別為100%及8 3 % ( p = 0 . 3 I7 ) 。五年的整體局部控制率為8 7 % '其中第一期、第二期、第三期及第四期患者的局部控制率分別為1 0 0 % 、100 % 、75 % 及50 % ( p = 0.695 ) 。有接受放射治療及沒有接受放射治療的五年局部控制率分別是7 5 %與1 0 0 % ( p = O . O的, 但有接受放射治療的局部症狀緩解效果佳) 。年紀小於2 5 歲及大於2 5 歲的五年局部控制率分別為1 00%及5 0 % ( p = O.OOOn 。 起益: 不論是何種治療方式, 蘭格漢氏組織細胞增多症患者皆有非常好的存活率, 因此我們建議對於這頡患者的治療應盡量避免產生副作用,並就疾病侵犯的程度來選擇治療方式。多處骨惜侵犯或神經侵犯似乎不會明顯的影響存活率。第一期及第二期患者的五年局部控制率和存活率沒有差異。
Purpose : To investigate the long-term treatment outcome of patients of Langerhans cell histiocytosis (LCH). Materials and Methods : Twenty patients with the diagnosis of LCH between January 1978 and December 2002 were included in our study. Median age was 12 years. Treatment included surgery, chemotherapy, radiotherapy, combination of multiple modalities and observation. The median follow-up is 87 months. Results : The 5-year overall and progression-free survival rates for all patients were 100% and 92%, respectively. The 5-year progression-free survival rates for patients treated with and without radiotherapy were 100% and 83%, respectively (p = 0.317). The overall local control rate was 87% at five years. Of these, the 5-year local control rates for stage 1, 2, 3, and 4 were 100%, 100%, 75%, and 50%, respectively (p = 0.695). The 5- year local control rates for patients treated with and without radiotherapy were 75% and 100%, respectively (p= 0.065, despite a good response to local radiotherapy). The 5-year local control rates for age ?25 and > 25 years were 100% and 50%, respectively (p = 0.0007). Conclusion : All of our LCH patients had a very high survival regardless of the treatment modalities. This suggests that less aggressive treatments may be the reasonable initial therapy to avoid side effects. The choice of treatment depends on the extent of disease. It seems that multiple bone or neurological involvement did not significantly influence survival. There is no difference in the 5-year local control and survival rates between stage 1 and 2.


    

本卷期目次
Therapeutic Radiology and Oncology
An Evaluation of the Contents and Quality of Radiation Oncology Homepages in Taiwan/ Yu-Jie HuangChong-Jong WangChang-Yu WangChing-Hui HsiehShiao-Hen Chang
預防動靜脈瘻管阻塞之狹長型電子射束劑量分析/ 柯卉玲許淑惠蕭安成李俊信林芳仁季匡華
Treatment Results of Langerhans Cell Histiocytosis: A Long Term Follow-Up/ Chun-Shu LinJing-Min HwangYee-Min JenYi-Jen PengLi-Ping ChangHsing-Lung ChaoDai-Wei LiuHon-Yi LinWeng-Yoon Shum
Granulocytic Sarcoma of the Uterine Cervix: A Case Report and Review of the Literature / Ming-Yii HuangShi-Long LianChih-Jen HuangSheng-Fung LinKun-Bow TsaiCheng-Hui Yang
頭頸部放射治療的活體劑量驗證/ 王慧娟羅素花董傳中吳嘉明王重榮
Metaplastic Carcinoma of the Breast: One Case Report and Literature Review/ Daniel WinardiShi-Long LianChih-Jen HuangKun-Bow TsaiJui-Sheng HsuMing-Feng Hou
Bile Duct Cancer, Its Survival and Local-Control after Radiotherapy/ Fu-Ti ChangNgan-Ming TsangYou-Kang ChangWai-Man Leung
癌症患者放射治療後迴診追蹤中斷的原因及分析/ 林奎利郭珍妮林立青林逢嘉蘇玫綺
BILE DUCT CANCER, ITS SURVIVAL AND LOCAL-CONTROL AFTER RADIOTHERAPY/ Fu-Ti ChangNgan-Ming TsangYou-Kang ChangWai-Man Leung
AN EVALUATION OF THE CONTENTS AND QUALITY OF RADIATION ONCOLOGY HOMEPAGES IN TAIWAN/ Yu-Jie HuangChong-Jong WangChang-Yu WangChing-Hui HsiehShiao-Hen Chang
癌症患者放射治療後迴診追蹤中斷的原因及分析/ 林奎利郭珍妮林立青林逢嘉蘇玫綺
預防動靜脈?管阻塞之狹長型電子射束劑量分析/ 柯卉玲許淑惠蕭安成李俊信林芳仁季匡華
頭頸部放射治療的活體劑量驗證/ 王慧娟羅素花董傳中吳嘉明王重榮陳惠君
TREATMENT RESULTS OF LANGERHANS CELL HISTIOCYTOSIS: A LONG TERM FOLLOW-UP/ Chun-Shu LinJing-Min HwangYee-Min JenYi-Jen PengLi-Ping ChangHsing-Lung ChaoDai-Wei LiuHon-Yi LinWeng-Yoon Shum
GRANULOCYTIC SARCOMA OF THE UTERINE CERVIX: A CASE REPORT AND REVIEW OF THE LITERATURE/ Ming-Yii HuangShi-Long LianChih-Jen HuangSheng-Fung LinKun-Bow TsaiCheng-Hui Yang
METAPLASTIC CARCINOMA OF THE BREAST: ONE CASE REPORT AND LITERATURE REVIEW/ Daniel WinardiShi-Long LianChih-Jen HuangKun-Bow TsaiJui-Sheng HsuMing-Feng Hou
 
   
 
   

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