原名「台灣學術線上」
包含TAO期刊庫 + TAO書籍庫 + 論文 + 史料文獻
首頁 | 關於TAO | 瀏覽 | 進階查詢 | 參考工具 | 會員服務 | 已購專書 | RSS服務 | 電子報 | FAQ  
查詢範圍:
   
查詢模式:
熱門查詢詞:
dvd賴氏肥料誘變
   
   
   
     
   
 
項次 書目
1
題名:BRAIN STEM DOSES FOR PATIENTS OF T3/T4 NASOPHARYNGEAL CARCINOMA TREATED BY BID IRRADIATION AND CONCOMITANT CHEMOTHERAPY     (28點)
局部嚴重性鼻咽癌病人一天兩次放射治療合併化學治療之腦幹劑量分佈長期追蹤研究成果
著者:Stella Y. C. Tsai(蔡玉真) ;Skye Hon-Giun Cheng(鄭鴻鈞) ;James Jer-Min Jian(簡哲民) ;Chao-Ming Huang(黃昭明) ;K. Lawrence Yen(閻愷正) ;Kwan-Yee Chan(詹光裕) ;Szu-Yun Leu(呂思韻) ;Yen-Chun Lin(林燕君) ;Nei-Min Chu(褚乃銘) ;Tran-Der Tan(譚傳德) ;Cheng-Yee Hsieh(謝政毅) ;Mei-Hua Tsou(曾美華) ;Ching-Yuan Lin(林敬原) ;Andrew T. Huang(黃達夫)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:鼻咽癌 ; 腦幹放射治療耐受度 ; 一天兩次放射治療 ; Nasopharyngeal carcinoma ; Brain stem tolerance ; Hyperfractionation radiation
刊名:Therapeutic Radiology and Oncology
頁碼:167-180
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:根據我們過去的經驗發現,對於局部嚴重性第三期及第四期的鼻咽癌病人,於顱底骨方向之放射線治療範圍安全距離必須大於一公分才能達到良好之局部控制。為了達到此目的,部份腦幹也會接受與原發腫瘤相近之高劑量;為了減少高放射治療劑量對腦幹之傷害,本院設計使用一天二次放射治療配合化學治療,以期達到提高局部控制率,而不造成長期腦幹受傷之研究。 材料與方法:於1991 年9 月至1998 年12 月,總共有69 位T3 、T4 鼻咽癌病人於和信醫院接受一天二次放射治療合併化學治療。原發腫瘤接受一天二次放射治療,一次1.2 Gy ,每週治療五天,總共74.4 Gy 分62 次給予。對於每一個病人之放射治療範圍之設計,於一開始之大範圍治療至40.8 至43.2 Gy ;安全距離為15 mm ,第一次縮小之治療範圍治療劑量至60 Gy ,安全距離則降為7 mm 至10 mm 。而最後加強照射之14.4 Gy ,則安全距離降為3 至7 mm 。69 位病人有25 位病人於1996 年之後接受治療,其原始治療計畫可以用目前我們三度空間的治療計畫來分析其腦幹的劑量分佈曲線。這25 位病人中其中5 位病人於三年內因疾病死亡,所以不列入統計。 結果:經過至少49 個月以及追蹤時間中位值97 個月的追蹤,這20 位病人的五年局部控制率為93.8% ,我們只觀察到其中一位病人有輕微的第二級同側上肢麻痺。這些病人沒有人因腦幹受傷而導致死亡。平均腦幹接受最高劑量為75.12 Gy 。平均腦幹接受大於50 Gy 、55 Gy 、60Gy 、65 Gy 及70 Gy 的體積分別為10.32 ml 、7.72 ml 、5.67 ml 、3.58 ml 及1.72 ml 。 結論:由我們的經驗,一天二次分次放射治療可以給予局部嚴重性鼻咽癌之病人足夠之放射線劑量以達良好局部控制而不造成長期腦幹功能之損傷。
Purpose : Our prior study revealed that at least 1 cm safe margin at clivus direction is necessary to obtain good local control of nasopharyngeal carcinoma (NPC). We retrospectively studied whether hyperfractionation irradiation to treat T3/T4 NPC patients could decrease the long-term side effect to the brain stem. Patients and Methods : Sixty-nine patients with T3/T4 (American Joint Committee on Cancer, 1997 staging system) NPC were treated with concomitant chemotherapy and twice a day radiation followed by adjuvant chemotherapy between September 1991 and December 1998 in Koo Foundation Sun Yat-Sen Cancer Center, Taipei. The planning dose of radiation was 74.4 Gy in 62 fractions, twice a day, 5 days per week. Every patient had 15 mm safe margin at clivus direction in the initial field to 40.8-43.2 Gy, 7mm to 10 mm to 60Gy at the 2nd boost field, and 3-7 mm at the final boost field to a total dose of 74.4 Gy. Twenty-five patients were treated between 1996 and 1998; their previous treatment plan data could be retrieved for analysis in our current CMS (Computerized Medical Systems, INC) three dimension treatment planning system for dose volume histogram calculation of brain stem. Five patients died from disease within 3 years after completion of treatment were excluded from the analysis. Results : With a minimal and median follow-up of 49 and 97 months, respectively, 5- year local control rate of the 20 patients was 93.8%. Brain stem toxicity was observed in one of 20 patients with the manifestation of grade II sensory loss at ipsilateral upper limb. There was no treatment related death. The average maximal dose to brain stem was 75.12 Gy and mean dose was 35.56 Gy. The average volumes of brain stem dose more than 50 Gy, 55 Gy, 60 Gy, 65 Gy, and 70 Gy were 10.32 ml, 7.72 ml, 5.67 ml, 3.58 ml, and 1.72 ml, respectively. Conclusion : Our data indicated that adequate irradiation dose could be given safely with hyperfractionation for T3/T4 NPC patients to achieve good local tumor control without significant long-term side effect to brain stem.


    

本卷期目次
Therapeutic Radiology and Oncology
鈷-60輻射污染鋼筋建物居民輻射風險因子之研究/ 蔡顯智許世明張國華陳為立
Long-Term Survival with No Evidence of Brain Metastasis in 6 Patients of Limited-Stage Small Cell Lung Cancer Receiving Prophylactic Cranial Irradiation/ Chia-Chun HuangMu-Tai LiuChu-Ping PiTung-Hao ChangWen-Shan LiuChao-Yuan Huang
Treatment Results and Prognostic Factors of Esthesioneuroblastoma (ENB)/ Yu-Ming WangChong-Jong WangEng-Yen HuangHui-Chun ChenLi-Min SunFu-Min FangHsuan-Chih HsuChing-Yeh HsiungYu-Jie HuangChang-Yu Wang
第一期下期與第二期上期之子宮頸癌經不同治療模式後的長期生活品質比較/ 許維中詹淑卿鍾娜娜陳宇嘉丁禮莉陳斯榮蔡崇煌王博民謝保群林高德
動態準直儀葉片於虛擬楔形濾板之研究/ 邱仲峰黃光偉李俊信顏上惠蕭正英陳培勳蔡若婷李玉麟陳良光
Radiotherapy in the Management of Localized Classic Kaposi's Sarcoma/ Yao-Ching WangLai-Lei TingChun-Ru ChienSung-Hsin KuoKuo-Ming HuangChao-Yuan HuangMing-Kuen LaiChia-Hsien Cheng
強度調控式放射治療之劑量驗證/ 梁基安蕭安成蘇經雄施文彬潘佳穎
Brain Stem Doses for Patients of T3/T4 Nasopharyngeal Carcinoma Treated by Bid Irradiation and Concomitant Chemotherapy/ Stella Y. C. TsaiSkye Hongiun ChengJames Jer-Min JianChao-Ming HuangK. Lawrence YenKwan-Yee ChanSzu-Yun LeuYen-Chun LinNei-Min ChuTran-Der TanCheng-Yee HsiehMei-Hua TsouChing-Yuan LinAndrew T. Huang
Metastatic Cardiac Tumor from Primary Tongue Cancer: A Case Report/ Tzu-Hwei WangWen-Shan Liu
BRAIN STEM DOSES FOR PATIENTS OF T3/T4 NASOPHARYNGEAL CARCINOMA TREATED BY BID IRRADIATION AND CONCOMITANT CHEMOTHERAPY/ Stella Y. C. TsaiSkye Hon-Giun ChengJames Jer-Min JianChao-Ming HuangK. Lawrence YenKwan-Yee ChanSzu-Yun LeuYen-Chun LinNei-Min ChuTran-Der TanCheng-Yee HsiehMei-Hua TsouChing-Yuan LinAndrew T. Huang
第一期下期與第二期上期之子宮頸癌經不同治療模式後的長期生活品質比較/ 許維中詹淑卿鍾娜娜陳宇嘉丁禮莉陳斯榮蔡崇煌王博民謝保群林高德
TREATMENT RESULTS AND PROGNOSTIC FACTORS OF ESTHESIONEUROBLASTOMA (ENB)/ Yu-Ming WangChong-Jong WangEng-Yen HuangHui-Chun ChenLi-Min SunFu-Min FangHsuan-Chih HsuChing-Yeh HsiungYu-Jie HuangChang-Yu Wang
RADIOTHERAPY IN THE MANAGEMENT OF LOCALIZED CLASSIC KAPOSI'S SARCOMA/ Yao-Ching WangLai-Lei TingChun-Ru ChienSung-Hsin KuoKuo-Ming HuangChao-Yuan HuangMing-Kuen LaiChia-Hsien Cheng
LONG-TERM SURVIVAL WITH NO EVIDENCE OF BRAIN METASTASIS IN 6 PATIENTS OF LIMITED-STAGE SMALL CELL LUNG CANCER RECEIVING PROPHYLACTIC CRANIAL IRRADIATION/ Chia-Chun HuangMu-Tai LiuChu-Ping PiTung-Hao ChangWen-Shan LiuChao-Yuan Huang
動態準直儀葉片於虛擬楔形濾板之研究/ 邱仲峰黃光偉李俊信?上惠蕭正英陳培勳蔡若婷李玉麟陳良光
強度調控式放射治療之劑量驗證/ 梁基安蕭安成蘇經雄施文彬潘佳穎
鈷-60輻射污染鋼筋建物居民輻射風險因子之研究/ 蔡顯智許世明張國華陳?立
METASTATIC CARDIAC TUMOR FROM PRIMARY TONGUE CANCER: A CASE REPORT/ Tzu-Hwei WangWen-Shan Liu
 
   
 
   

與TAO合作 | 隱私與版權聲明 | 聯絡方式 | 下載Adobe Reader
地址:台北市中正區(100)北平東路30-12號3樓
電話:(02)2393-6968 傳真:(02)2393-6877
Email: service@wordpedia.com
Wordpedia Family: 學校、企業版入口 | 遠流影音館
Copyright©2011 Wordpedia Co., Ltd. All Rights Reserved.