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1
題名:RADIOTHERAPY IN THE MANAGEMENT OF LOCALIZED CLASSIC KAPOSI'S SARCOMA     (16點)
局限性傳統卡波西氏肉瘤的放射線治療
著者:Yao-Ching Wang(王耀慶) ;Lai-Lei Ting(丁禮莉) ;Chun-Ru Chien(簡君儒) ;Sung-Hsin Kuo(郭頌鑫) ;Kuo-Ming Huang(黃國明) ;Chao-Yuan Huang(黃昭源) ;Ming-Kuen Lai(賴明坤) ;Chia-Hsien Cheng(成佳憲)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:傳統性卡波西氏肉瘤 ; 放射線治療 ; 劑量 ; 治療反應 ; Classic Kaposi's sarcoma ; Radiotherapy ; Dose ; Response
刊名:Therapeutic Radiology and Oncology
頁碼:199-206
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:傳統性卡波西氏肉瘤是緩慢進展的腫瘤,其盛行在東歐及地中海沿岸人種,但是甚少發生於其他種族。放射線治療對於僅有局部少數病灶的病人可以提供解除症狀及腫瘤控制,但是對於大範圍的治療並不容易。本篇研究的目的在評估傳統性卡波西氏肉瘤對於放射線治療的局部控制及症狀解除的效果。 材料與方法:自1994 年8 月至2004 年11 月間,從本院癌登室的資料, 48 位有組織學證明為卡波西氏肉瘤的病患被選出回顧。符合資格的有11 位病患,皆非人類免疫不全病毒陽性及接受器官移植者。局部治療的方式利用鈷60 ,百萬電子伏特能量的光子或電子射線。由臨床狀況決定照野的範圍,照射的次數及總劑量。 結果:總共11 位病患有20 個病灶進入這個研究。其中9 位是男性, 2 位是女性,平均年齡為66 歲。存活病人的追蹤期為4 至44 個月(中位數為17 個月)。治療的目標劑量從30 Gy/10 次到40 Gy/20 次,但是有4 個病灶(2 位病患)有例外情形。在所有的20 個治療病灶中,有15個治療病灶有完全消退反應(75%),而其他皆為部分消退反應。無復發期間的中位數至目前為止尚未獲得。3 個月, 6 個月及一年半的局部控制率分別為95% , 74% 和74% 。所有的病人都達到症狀解除,而慢性的副作用包含滲液性皮膚炎或各種程度的水腫是很少發生和輕微的。 結論:儘管有輕微的水腫和色素沈著的慢性副作用,局部的放射線治療對傳統性卡波西氏肉瘤是耐受性佳的且有效的治療方式。本篇資料建議局部放射線治療對於局部的非人類免疫不全病毒相關的傳統性卡波西氏肉瘤是有效的治療方式。
Purpose : Classic Kaposi’s sarcoma (CKS) is a prevalent indolent neoplasm among Eastern European and Mediterranean origin, but is rare in the other ethnic groups. Radiotherapy may provide symptom relief and tumor control in patients who have a few lesions in a limited area. This study was to assess the effectiveness of radiotherapy in the local control and the symptom relief of the CKS. Materials and Methods : Between August 1994 and November 2004, 48 patients with histologically proven Kaposi’s sarcoma were selected for review from the Cancer Registry of National Taiwan University Hospital, eleven patients were both human immunodeficiency virus (HIV)-negative and non organ-transplant recipients. These patients received radiotherapy and were eligible for this study. Treatment methods consisted of local radiotherapy using Cobalt-60 teletherapy, megavoltage photon beam or electron beam. The treatment fields, fractionation, and total dose of radiation were determined on the clinical basis. Results : A total of 11 patients (20 lesions) were enrolled into this study. There were 9 men and 2 women, with a mean age of 66 years. Median follow-up for surviving patients ranged from 4 to 44 months (median, 17 months). Target dose ranged from 30 Gy in ten fractions to 40 Gy in twenty fractions, with the exceptions in four lesions (2 patients). The complete response rate was 75% (15 lesions), and the partial response was evident in the remaining lesions. Median free from recurrence interval has not been reached. The 3-month, 6-month and 1.5-year local regional control rates were 95%, 74% and 74%, respectively. Symptom relief was achieved in all patients. Chronic complications including exudative dermatitis and variable degrees of edema were rare and mild. Conclusion : With the few late complication of mild edema and hyperpigmentation, local radiotherapy to CKS was well tolerated and effective. These data suggest that the local radiotherapy remains the effective treatment modality for non-HIV related localized classic Kaposi’s sarcoma.


    

本卷期目次
Therapeutic Radiology and Oncology
動態準直儀葉片於虛擬楔形濾板之研究/ 邱仲峰黃光偉李俊信顏上惠蕭正英陳培勳蔡若婷李玉麟陳良光
Radiotherapy in the Management of Localized Classic Kaposi's Sarcoma/ Yao-Ching WangLai-Lei TingChun-Ru ChienSung-Hsin KuoKuo-Ming HuangChao-Yuan HuangMing-Kuen LaiChia-Hsien Cheng
強度調控式放射治療之劑量驗證/ 梁基安蕭安成蘇經雄施文彬潘佳穎
Long-Term Survival with No Evidence of Brain Metastasis in 6 Patients of Limited-Stage Small Cell Lung Cancer Receiving Prophylactic Cranial Irradiation/ Chia-Chun HuangMu-Tai LiuChu-Ping PiTung-Hao ChangWen-Shan LiuChao-Yuan Huang
第一期下期與第二期上期之子宮頸癌經不同治療模式後的長期生活品質比較/ 許維中詹淑卿鍾娜娜陳宇嘉丁禮莉陳斯榮蔡崇煌王博民謝保群林高德
Treatment Results and Prognostic Factors of Esthesioneuroblastoma (ENB)/ Yu-Ming WangChong-Jong WangEng-Yen HuangHui-Chun ChenLi-Min SunFu-Min FangHsuan-Chih HsuChing-Yeh HsiungYu-Jie HuangChang-Yu Wang
鈷-60輻射污染鋼筋建物居民輻射風險因子之研究/ 蔡顯智許世明張國華陳為立
Brain Stem Doses for Patients of T3/T4 Nasopharyngeal Carcinoma Treated by Bid Irradiation and Concomitant Chemotherapy/ Stella Y. C. TsaiSkye Hongiun ChengJames Jer-Min JianChao-Ming HuangK. Lawrence YenKwan-Yee ChanSzu-Yun LeuYen-Chun LinNei-Min ChuTran-Der TanCheng-Yee HsiehMei-Hua TsouChing-Yuan LinAndrew T. Huang
Metastatic Cardiac Tumor from Primary Tongue Cancer: A Case Report/ Tzu-Hwei WangWen-Shan Liu
BRAIN STEM DOSES FOR PATIENTS OF T3/T4 NASOPHARYNGEAL CARCINOMA TREATED BY BID IRRADIATION AND CONCOMITANT CHEMOTHERAPY/ Stella Y. C. TsaiSkye Hon-Giun ChengJames Jer-Min JianChao-Ming HuangK. Lawrence YenKwan-Yee ChanSzu-Yun LeuYen-Chun LinNei-Min ChuTran-Der TanCheng-Yee HsiehMei-Hua TsouChing-Yuan LinAndrew T. Huang
第一期下期與第二期上期之子宮頸癌經不同治療模式後的長期生活品質比較/ 許維中詹淑卿鍾娜娜陳宇嘉丁禮莉陳斯榮蔡崇煌王博民謝保群林高德
TREATMENT RESULTS AND PROGNOSTIC FACTORS OF ESTHESIONEUROBLASTOMA (ENB)/ Yu-Ming WangChong-Jong WangEng-Yen HuangHui-Chun ChenLi-Min SunFu-Min FangHsuan-Chih HsuChing-Yeh HsiungYu-Jie HuangChang-Yu Wang
RADIOTHERAPY IN THE MANAGEMENT OF LOCALIZED CLASSIC KAPOSI'S SARCOMA/ Yao-Ching WangLai-Lei TingChun-Ru ChienSung-Hsin KuoKuo-Ming HuangChao-Yuan HuangMing-Kuen LaiChia-Hsien Cheng
LONG-TERM SURVIVAL WITH NO EVIDENCE OF BRAIN METASTASIS IN 6 PATIENTS OF LIMITED-STAGE SMALL CELL LUNG CANCER RECEIVING PROPHYLACTIC CRANIAL IRRADIATION/ Chia-Chun HuangMu-Tai LiuChu-Ping PiTung-Hao ChangWen-Shan LiuChao-Yuan Huang
動態準直儀葉片於虛擬楔形濾板之研究/ 邱仲峰黃光偉李俊信?上惠蕭正英陳培勳蔡若婷李玉麟陳良光
強度調控式放射治療之劑量驗證/ 梁基安蕭安成蘇經雄施文彬潘佳穎
鈷-60輻射污染鋼筋建物居民輻射風險因子之研究/ 蔡顯智許世明張國華陳?立
METASTATIC CARDIAC TUMOR FROM PRIMARY TONGUE CANCER: A CASE REPORT/ Tzu-Hwei WangWen-Shan Liu
 
   
 
   

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