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1
題名:LONG-TERM SURVIVAL WITH NO EVIDENCE OF BRAIN METASTASIS IN 6 PATIENTS OF LIMITED-STAGE SMALL CELL LUNG CANCER RECEIVING PROPHYLACTIC CRANIAL IRRADIATION     (14點)
侷限型小細胞肺癌病人接受預防性腦部照射後長期存活且無腦部轉移
著者:Chia-Chun Huang(黃家俊) ;Mu-Tai Liu(劉幕台) ;Chu-Ping Pi(畢祖平) ;Tung-Hao Chang(張東浩) ;Wen-Shan Liu(劉文山) ;Chao-Yuan Huang(黃昭源)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:小細胞肺癌 ; 預防性腦部放射線照射 ; 長期追蹤 ; 腦部轉移 ; Small Cell Lung Cancer ; Prophylactic Cranial Irradiation ; Long-term Follow-up ; Brain Metastasis
刊名:Therapeutic Radiology and Oncology
頁碼:207-213
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:小細胞肺癌病人在初始治療之後若達到局部完全緩解,通常會建議接受預防性腦部放射線照射。在本文中,我們報告了6 位侷限型小細胞肺癌病人接受預防性腦部照射後,持續3 年以上無腦部轉移。 材料與方法:自1998 年11 月至2002 年1 月,有6 位診斷為小細胞肺癌的病人。其中5 位(83%)是男性, 1 位(17%)是女性。病人的平均年齡是61 歲。所有病人的癌症期別皆為侷限期小細胞肺癌。根據ECOG (Eastern Cooperative Oncology Group) performance status 狀態來評分, 1位病人(17%)是ECOG 0 , 4 位(66%)是ECOG 1 , 1 位(17%)是ECOG 2 。所有病人皆接受同步化學與放射線治療。化學治療的藥物為Cisplatin 與Etoposide 。肺部的放射線治療劑量中位數為54 Gy 。所有6 位病人皆達到局部完全緩解,並且接受總劑量中位數為36 Gy 的預防性腦部放射線照射。 結果:所有6 位病人在最近一次追蹤中皆存活,並且持續3 年以上無腦部轉移。最長的追蹤時間為75 個月。3 位病人(50%)有腦部以外的轉移,包括了2 位病人有骨轉移, 1 位病人有腎臟轉移。 結論:侷限型小細胞肺癌病人在同步化學治療與放射線治療後,若達到完全緩解並且接受預防性腦部照射,可以達到長期存活且無腦部轉移的結果。不過,一半以上的病人仍舊有腦部以外的遠端轉移。相對於其他部位的轉移,預防性腦部放射線照射能夠有效避免腦部轉移的發生.
Background : Prophylactic cranial irradiation (PCI) is generally suggested for limitedstaged small cell lung cancer (SCLC) patients with complete local response to initial therapies. We presented 6 patients with no evidence of brain metastasis for more than 3- year follow-up after receiving PCI. Materials and Methods : From November 1998 through January 2002, 6 patients were diagnosed as SCLC in our institution. Five patients (83%) were male and 1 (17%) was female. The median age at diagnosis was 61 years. All patients were classified as limited stage. According to ECOG (Eastern Cooperative Oncology Group) performance status, 1 patient (17%) was scaled to 0, 4 patients (66%) were 1, and 1 patient (17%) was 2. All patients were treated with concurrent chemoradiotherapy (CCRT). Chemotherapy regimens consisted of cisplatin and etoposide. The median cumulative thoracic irradiation dose was 54Gy. All 6 patients achieved complete local response after CCRT, and then they received PCI with median cumulative dose of 36Gy. Results : All patients were alive and had a long-term follow-up more than 3 years with no evidence of brain metastasis. The longest follow-up duration was 75 months. Three patients (50%) had metastasis to distant sites other than brain, including 2 patients with bone and one patient with kidney metastases. Conclusions : In our study, long-term survival with no evidence of brain metastasis was achieved in patients of SCLC receiving PCI after complete local response to initial treatments of CCRT. Distant metastases to other sites still developed in half of these patients. PCI might have benefits in preventing distant metastasis to brain on the respect of failures to other distant sites with long-term follow-up.


    

本卷期目次
Therapeutic Radiology and Oncology
第一期下期與第二期上期之子宮頸癌經不同治療模式後的長期生活品質比較/ 許維中詹淑卿鍾娜娜陳宇嘉丁禮莉陳斯榮蔡崇煌王博民謝保群林高德
Long-Term Survival with No Evidence of Brain Metastasis in 6 Patients of Limited-Stage Small Cell Lung Cancer Receiving Prophylactic Cranial Irradiation/ Chia-Chun HuangMu-Tai LiuChu-Ping PiTung-Hao ChangWen-Shan LiuChao-Yuan Huang
Treatment Results and Prognostic Factors of Esthesioneuroblastoma (ENB)/ Yu-Ming WangChong-Jong WangEng-Yen HuangHui-Chun ChenLi-Min SunFu-Min FangHsuan-Chih HsuChing-Yeh HsiungYu-Jie HuangChang-Yu Wang
Radiotherapy in the Management of Localized Classic Kaposi's Sarcoma/ Yao-Ching WangLai-Lei TingChun-Ru ChienSung-Hsin KuoKuo-Ming HuangChao-Yuan HuangMing-Kuen LaiChia-Hsien Cheng
強度調控式放射治療之劑量驗證/ 梁基安蕭安成蘇經雄施文彬潘佳穎
動態準直儀葉片於虛擬楔形濾板之研究/ 邱仲峰黃光偉李俊信顏上惠蕭正英陳培勳蔡若婷李玉麟陳良光
鈷-60輻射污染鋼筋建物居民輻射風險因子之研究/ 蔡顯智許世明張國華陳為立
Brain Stem Doses for Patients of T3/T4 Nasopharyngeal Carcinoma Treated by Bid Irradiation and Concomitant Chemotherapy/ Stella Y. C. TsaiSkye Hongiun ChengJames Jer-Min JianChao-Ming HuangK. Lawrence YenKwan-Yee ChanSzu-Yun LeuYen-Chun LinNei-Min ChuTran-Der TanCheng-Yee HsiehMei-Hua TsouChing-Yuan LinAndrew T. Huang
Metastatic Cardiac Tumor from Primary Tongue Cancer: A Case Report/ Tzu-Hwei WangWen-Shan Liu
BRAIN STEM DOSES FOR PATIENTS OF T3/T4 NASOPHARYNGEAL CARCINOMA TREATED BY BID IRRADIATION AND CONCOMITANT CHEMOTHERAPY/ Stella Y. C. TsaiSkye Hon-Giun ChengJames Jer-Min JianChao-Ming HuangK. Lawrence YenKwan-Yee ChanSzu-Yun LeuYen-Chun LinNei-Min ChuTran-Der TanCheng-Yee HsiehMei-Hua TsouChing-Yuan LinAndrew T. Huang
第一期下期與第二期上期之子宮頸癌經不同治療模式後的長期生活品質比較/ 許維中詹淑卿鍾娜娜陳宇嘉丁禮莉陳斯榮蔡崇煌王博民謝保群林高德
TREATMENT RESULTS AND PROGNOSTIC FACTORS OF ESTHESIONEUROBLASTOMA (ENB)/ Yu-Ming WangChong-Jong WangEng-Yen HuangHui-Chun ChenLi-Min SunFu-Min FangHsuan-Chih HsuChing-Yeh HsiungYu-Jie HuangChang-Yu Wang
RADIOTHERAPY IN THE MANAGEMENT OF LOCALIZED CLASSIC KAPOSI'S SARCOMA/ Yao-Ching WangLai-Lei TingChun-Ru ChienSung-Hsin KuoKuo-Ming HuangChao-Yuan HuangMing-Kuen LaiChia-Hsien Cheng
LONG-TERM SURVIVAL WITH NO EVIDENCE OF BRAIN METASTASIS IN 6 PATIENTS OF LIMITED-STAGE SMALL CELL LUNG CANCER RECEIVING PROPHYLACTIC CRANIAL IRRADIATION/ Chia-Chun HuangMu-Tai LiuChu-Ping PiTung-Hao ChangWen-Shan LiuChao-Yuan Huang
動態準直儀葉片於虛擬楔形濾板之研究/ 邱仲峰黃光偉李俊信?上惠蕭正英陳培勳蔡若婷李玉麟陳良光
強度調控式放射治療之劑量驗證/ 梁基安蕭安成蘇經雄施文彬潘佳穎
鈷-60輻射污染鋼筋建物居民輻射風險因子之研究/ 蔡顯智許世明張國華陳?立
METASTATIC CARDIAC TUMOR FROM PRIMARY TONGUE CANCER: A CASE REPORT/ Tzu-Hwei WangWen-Shan Liu
 
   
 
   

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