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1
題名:Fractionated High-Dose-Rate Stereotactic Brachytherapy in the Management of Malignant Gliomas     (14點)
惡性膠質細胞瘤之立體定位分次高劑量率近接治療
著者:Wen-Cheng Chen(陳文政) ;Jami Yeh(葉健一) ;Simon G. Tang(湯國政) ;Kuo-Chen Wei(魏國珍) ;Chen-Nen Chang(張承能) ;David Y. C. Huang(黃英強)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:膠質細胞瘤 ; 近接治療 ; 高劑量率 ; 立體定位 ; Glioma ; Brachytherapy ; High-dose-rate ; Stereotactic
刊名:Therapeutic Radiology and Oncology
頁碼:115-121
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

高劑量率立體定位近接治療技術已成功被引進,用於治療惡性膠質細胞瘤之病患。首先,先將CRW鐵環固定於病人頭上,戴上電腦斷層定位框後,病人接受電腦斷層掃描。電腦斷層影像經由光碟片傳送至三度空間治療計劃軟體(BrainSCAN)。先前之治療計劃,經由導管數目、位置及各導管內射源停留的位置及時間的決定而產生。最主要的目標是使標的體積內達到最均勻的劑量,而在標的體積外的劑量快速遞減。一旦決定好治療計劃,病人再送至開刀房。依據先前的治療計劃,腦神經外科醫師使用手鑽在頭殼上打一個小洞,再將導管置入預定位置中。藉著互相垂直方向照得的X光片,可以驗證真王導管及先前治療計劃導管位置的差異。經過適當地調整射源位置及停留時問以彌補導管位置的誤差,再將病人以MicroSelectron後荷治療機施行治療。根據我們的初步經驗,已開始進行第一/二相的研究試驗。
A stereotactic high-dose-rate brachytherapy technique has recently been implemented for the treatment of malignant gliomas. A Cosman-Roberts-Wells (CRW) base ring is attached to the patient's skull with a CT localization frame attached to the base ring. The patient undergoes a contrast enhanced CT scanning. The CT images are transferred to the three-dimensional stereotactic brachytherapy treatment planning system (Brain-SCAN) through optical disc. Then the pre-plan is generated to determine the number of catheters, the location of each catheter, the source positions in each catheter and the implant time. The goal is to provide a steep dose fall off outside the target volume while providing the best possible dose homogeneity within the target volume. Once the plan is approved, the patient is taken to the operation room. According to the pre-plan data, neurosurgeons make a small hole by twist-drill on the skull and then place the catheters into the desired location. Later on, the real positions of catheters in the brain are verified by orthogonal radiographics and compare with the preplanned positions. After adjusting the implant time and position of each seed to compromise the position deviation of catheters, the patient is treated with MicroSelectron unit. High activity Ir-192 source is afterloaded into the catheters by remote-control system. Based on our preliminary experience, a phase I/II clinical study has been initiated.


    

本卷期目次
Therapeutic Radiology and Oncology
以電腦斷層攝影為影像基礎的順形放射治療:技術細節與初步經驗/ 王重榮梁雲陳惠君蔡宗翰孫立民方富民吳嘉明陳春志
胸腔部位放射治療之能量選擇-物理考量/ 劉文山蔡麗芳吳永平陳及三張慶雄顏上惠陳光耀
鼻咽癌斜位眼眶下照射部位之問接驗證/ 顏上惠林光大梁錦榮蕭正英陳光耀
Hyperfractionated Radiotherapy of Lung Cancer: Report of a Pilot Study/ Yee-Min JenWen-Lin HsuChing-Jung WuPei-Wei ShuengChih-Chung SuJing-Ming HwangTung-Hao Chang
The Interplay of Chemotherapy and Radiation Therapy in Pediatric Oncology Risks Versus Benefits/ Giulio J. D'Angio
赫濟時的基礎教育一位對中國大陸與台灣放射線學有鉅大貢獻的教授早年經歷/ 陳光耀
國立台灣大學附設醫院放射治療科的發展/ 雷德丁禮莉王博民方麗麗鍾娜娜
Fractionated High-Dose-Rate Stereotactic Brachytherapy in the Management of Malignant Gliomas/ Wen-Cheng ChenJami YehSimon G. TangKuo-Chen WeiChen-Nen ChangY. C. Huang
Inauguration Speech of the President of the American Bureau for Medical Advancement in China at the Annual Meeting of the Board of Directors/ Gerard M. Turino
Induction Chemotherapy Followed by Radiotherapy in Locally Advanced Cervical Cancer: A Review / Pei-Wei ShuengWen-Lin HsuYee-Min JenChing-Jung Wu
赫濟時醫師的專業訓練/ 陳光耀
Induction Chemotherapy Followed by Radiotherapy in Locally Advanced Cervical Cancer: A Review/ Pei-Wei ShuengWen-Lin HsuYee-Min JenChing-Jung Wu
Fractionated High-Dose-Rate Stereotactic Brachytherapy in the Management of Malignant Gliomas/ Wen-Cheng ChenJami YehSimon G. TangKuo-Chen WeiChen-Nen ChangDavid Y. C. Huang
Hyperfractionated Radiotherapy of Lung Cancer: Report of a Pilot Study/ Yee-Min JenWen-Lin HsuChing-Jung WuPei-Wei ShuengChih-Chung SuJing-Ming HwangTung-Hao Chang
以電腦斷層攝影為影像基礎的順形放射治療:技術細節與初步經驗/ 王重榮梁雲陳惠君蔡宗翰孫立民方富民吳嘉明陳春志
胸腔部位放射治療之能量選擇--物理考量/ 劉文山蔡麗芳吳永平陳及三張慶雄顏上惠陳光耀
鼻咽癌斜位眼眶下照射部位之間接驗證/ 顏上惠林光大梁錦榮蕭正英陳光耀
國立台灣大學附設醫院放射治療科的發展/ 雷德丁禮莉王博民方麗麗鍾娜娜
赫濟時的基礎教育一位對中國大陸與台灣放射線學有鉅大貢獻的教授早年經歷/ 陳光耀
赫濟時醫師的專業訓練/ 陳光耀
Inauguration Speech of the President of the American Bureau for Medical Advancement in China at the Annual Meeting of the Board of Directors/ Gerard M. Turino
The Interplay of Chemotherapy and Radiation Therapy in Pediatric Oncology Risks Versus Benefits/ Giulio J. D'Angio
Long-Term Follow-Up of Cervical Cancer Patients Treated with Preloaded Radium Brachytherapy from 1977 to 1983/ Lily FongLouis Tak LuiLai-Lei TingSHU-CHEN HUANGChang-Yao Hsieh
 
   
 
   

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