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1
題名:Results of Radiation Therapy for Regional Stage T4 Nasopharyngeal Carcinoma     (18點)
局部T4期鼻咽癌放射治療的結果
著者:Chi-Yuan Yeh(葉啓源) ;Yuen-Liang Lai(賴允亮) ;Chang-Hung Chung(鍾昌宏) ;Kou-Hwa Chang(張國華) ;Yih-Cherng Lai(賴易成)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:鼻咽癌 ; 放射治療 ; Nasopharyngeal Carcinoma ; Radiotherapy
刊名:Therapeutic Radiology and Oncology
頁碼:193-201
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

本研究從1 9 70年1月到1 9 88年1 2 月間,共搜集1 4 2位T4 期鼻咽癌接受放射治療的病患而做回顧性分析。其中有90位病患有接受完整的放射治療:有1 8位病患放射治療中中斷,另有34位病患接受放射治療後2個月內併發達端轉移,所以共有52位病患未列入分析。腫瘤原發處所給予的平均劑量為73 Gy ' 而頸部淋巴轉移部分則根據大小給予放射劑量範圍在50 Gy 至70 Gy 之間。鼻咽癌病患T4 期又分為T鉤' T 4 n ' T4bn 等三組, 侵犯顱底的T4b 組有3 7 位: 造成腦神經麻庫的T4n 組有23 位: 合併顱底與腦神經侵犯者(T4 bn)有30位。研究分析結果顯示:腫瘤局部控制率與腦神經被侵犯的數目,腫瘤細胞分化和輻射生物等效劑量三著有關。影響患者實際存活率因素包括:腫瘤細胞分化程度, 屬於何種T4 期分組( T4 b 期以4 9 . 5 % 的五年存活率為最好) 和腫瘤侵犯顱窩的部位( 侵犯中顱窩的五年存活率是4 8 % ' 比後顱窩侵犯1 9 . 6 %和中後顱窩侵犯2 9 . 2 %較好, p <0.0 5) 。這90 位T4 期鼻咽癌病患的五年總存活率是5 6 . 5 % ' 局部復發率為3 4.4 %而無發病期中值時間為1 5 個月。
A retrospective analysis of 142 cases of stage T4 nasopharyngeal carcinoma (NPC) treated with radiotherapy between Jan. 1970 and Dec. 1988 was undertaken. Ninety patients completed radiotherapy while 52 patients were excluded due to incomplete radiotherapy (18 pt) or syst emic disea se within 2 months after radiotherapy (34 pt). The mean dose given to the primary tumor was 73 Gy while neck node metastasis received a dose ranging from 50 Gy to 70 Gy depending on nodal size. The patients were subclas sified into stage T4b for skull base invasion(37 pt) , T4n for cranial nerve palsy (23 pt ) and T4bn for bone and nerve in volvement (30 pt). Analysis showed that local control was associated wit h the numb er of cranial nerve invol ved, tumor grade and biological dose equivalent (BED). Actuarial sur vival was sig nificantly influenced by tumor gr ade, T stage with T4b showing the best surv ival (5- year = 49.5%), and site of tumor in vasion with middle cranial fossa involvement showing a higher 5 year surv ival compared with posterior and middle-posterior cranial fossa in volvement (48% vs. 19.6% vs. 29.2% re spectively, p <0.05). The overa1l 5-year surv ival for these 90st age T4 regional NPC patients was 56.5%, the local recurrence rate was 34.4% with a median-disease free interval of 15 months.


    

本卷期目次
Therapeutic Radiology and Oncology
Patterns of Pelvic Recurrence and Results of Salvage Treatment with Radiation Therapy for Recurrent Rectal Carcinoma/ Chong-Jong WangStephen Wan LeungHui-Chun ChenLi-Min SunFu-Min Fang
Postoperative Radiotherapy for Malignant Gliomas/ Shyh-An YehStephen Wan LeungLi-Mm SunChong-Jong WangHuey-Jiun ChenFu-Min Fang
Postoperative Low Dose Single Fraction Irradiation for Prevention of Heterotopic Bone Formation after Hip Surgery/ Le-Jung WuSang-Hue YenTain-Hsiung ChenLing-Wei WangKwan-Hwa ChiKuang Y. Chen
C型行為與癌的關系-癌症心理學書評-/ 陳光耀
接受輻射治療之鼻咽腫瘤患者其視綱膜病變之評估/ 張東杰林淵謙陳墩祿楊克仁陳麗惠湯國政
西藏癌症與衛生醫療現況/ 顏上惠劉淑娟陳光耀
Results of Radiation Therapy for Regional Stage T4 Nasopharyngeal Carcinoma/ Chi-Yuan YehYuen-Liang LaiChang-Hung ChungKou-Hwa ChangYih-Cherng Lai
醫用直線加速器系統構造與保養作業簡介/ 李財福梁雲王重榮許順能黃置柔吳嘉明
Study on Radiation Safety of High Dose Rate Multiple Cobalt-60 Sources Teletherapy Machine/ Sang-Hue YenYuh-Lin LeeLiung S. ChaoMax M. ChaoDavid HC PanKuang Y. Chen
維生素丙對鼷鼠放射線口腔黏膜炎修復與預防效應之研究/ 許文林黃經民任益民施榕平李恒昇李偉華
The Role of Epstein-Barr Virus Infection and the Immunocompetence of Patients with Nasopharyngeal Cancer/ Kuan-Chih ChowKuang Y. Chen
Curative Radiotherapy for Vocal Cord Carcinoma/ Weng Yih-ChyangJin-Ching LinJian-Sheng Jan
如何使用模擬攝影機之擋影托盤(shadow tray)确認擋塊位置/ 何聖佑鄭秀成雷德
維生素丙對所鼷鼠放射線口腔黏膜炎修復與預防效應之研究/ 詩文林黃經民任益民施榕平李恆昇李偉華
Curative Radiotherapy for Vocal Cord Carcinoma/ Yih-Chyang WengJin-Ching LinJian-Sheng Jan
Results of Radiation Therapy for Regional Stage T4 Nasopharyngeal Carcinoma/ Chi-Yuan YehYuen-Liang LaiChang-Hung ChungKou-Hwa ChangYih-Cherng Lai
接受輻射治療之鼻咽腫瘤患者其視網膜病變之評估/ 張東杰林淵謙陳墩禄楊克仁陳麗惠湯國政
Postoperative Low Dose Single Fraction Irradiation for Prevention of Heterotopic Bone Formation after Hip Surgery/ Le-Jung WuSang-Hue YenTain-Hsiung ChenLing-Wei WangKwan-Hwa ChiKuang Y. Chen
Patterns of Pelvic Recurrence and Results of Salvage Treatment with Radiation Therapy for Recurrent Rectal Carcinoma/ Chong-Jong WangStephen Wan LeungHui-Chun ChenLi-Min SunFu-Min Fang
Postoperative Radiotherapy for Malignant Gliomas/ Shyh-An YehStephen Wan LeungLi-Min SunChong-Jong WangHuey-Jiun ChenFu-Min Fang
Study on Radiation Safety of High Dose Rate Multiple Cobalt-60 Sources Teletherapy Machine/ Sang-Hue YenYuh-Lin LeeLiung S. ChaoMax M. ChaoDavid HC PanKuang Y. Chen
The Role of Epstein-Barr Virus Infection and the Immunocompetence of Patients with Nasopharyngeal Cancer/ Kuan-Chih ChowKuang Y. Chen
如何使用模擬攝影機之擋影托盤(shadow tray)確認擋塊位置/ 何聖佑鄭秀成雷德
醫用直線加速器系統構造與保養作業簡介/ 李財福梁雲王重榮許順能黃置柔吳嘉明
西藏癌病與衛生醫療現況/ 顏上惠劉淑娟陳光耀
C型行為與癌的關係--癌症心理學書評--/ 陳光耀
 
   
 
   

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