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1
題名:The Role of Epstein-Barr Virus Infection and the Immunocompetence of Patients with Nasopharyngeal Cancer     (36點)
EB病毒的感染與鼻咽癌病人的免疫力
著者:Kuan-Chih Chow(周寬基) ;Kuang Y. Chen(陳光耀)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:EB病毒 ; 鼻咽癌 ; 介白素 ; 免疫能力 ; EBV ; NPC ; Interleukins ; Immunocomprimise
刊名:Therapeutic Radiology and Oncology
頁碼:243-260
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

鼻咽癌患者血清中對EB病毒I gA滴度普遍升高, 而且癌巢內及附近淋巴細胞浸潤大量增加。可是病人的免疫力卻反而衰退。 因為介白素十號(I L - 1 0 )有壓抑細胞性免疫反應(例如殺手細胞及吞噬細胞) . 卻提昇體液性免疫反應(例如抗體的產生) 的作用, 而EB病毒晚期基因BC RF 1與介白素十號有相似的基因序列(又稱vI L- 10) •也可能具有相似的功能。再者可溶性介白素二號受體(I L - 2 R) 也可能壓抑細胞性免疫反應, 因此,本文就針對這些EB病毒感染與鼻咽癌病人的免疫力等問題提出一些我們的看法,藉著分析與EB病毒有關的疾病' EB病毒的致癌機轉,細胞與病毒的相互作用,細胞培養的模式,病毒因素與其他致病因素的作用,進而討論病毒在癌細胞中究竟是潛伏性感染或是再激活感染, 也由此揮討病人免疫力的減弱和疾病的惡化。希望能由科學上的觀察幫助了解病人免疫力降低的可能原因,對臨床的現象有更好的解釋,並為未來的免疫治療、基因治療或免疫基因治療的設計,提供一個理論基礎。
Seral IgA titer to gene products of Epstein-Barr vir us is prevalently elevated in patients with nasopharyngeal carcinoma, an indication of EBV infection. Pathologically, tumor infiltrating lymphocytes that could be attracted by the presence of EBV in the NPC cells also increased immensely in the neighborhood of tumor nes t. In a glance, EBV seemed to induce both cellular and humoral immune response. However, the immunocompetence of patients inversely decreased following the progression of the disease. Interleukin -l0 (IL-I0), a potent cytokine synthesis inhibitory factor , suppr esses function of T cells and NK cells as well as that of monocytes and macrophages, the major components of cellular immune response. Besides it s suppr ession on cellular immunity, IL-I0 stimulates B cell s to enhance t heir viability, cell proliferation , class II MHC expression and immunoglobulin secret ion, a hallmark of humoral immune response. Interestingly, sequence of a EBV late gen e, BCRFl, is highly homologous to that of both mouse and human IL-I0(BCRFl gene product is now designated as vIL-I0). It may exe r t a similar function lik e that of IL-I0. The act ivity of vIL-I0 may explain the unusual seral phenomen a and the aggregated non-functional lymphocytes sur rounding t he tumor nest. Ant ho r fa ctor affecting the cellular immunity is the presence of soluble interleukin-2 receptor (sIL-2R) that will compete with the membrane-bound IL-2R and desensitize the immune response. With these leads, the authors will discuss the subject “t he role of Epst ein-Barr virus infection and the immunocompetence of patients with na sopharyngeal cancer“in the following catogories: EBV -a ssociated diseases and oncogenes is, virus-cell interaction,cell cult ure model, synergist ic effect between vir al and other risk fa ctors, latent infection or the reactivated infection, and abrogation of immunocompetence and tumor progression. Hopefully, the discussion will delineate the plau sible reason for t he decreasing immunocompetenc e in patients with NPC and will provide a better explanation for the clini cal phenomena as well as the t he oret ical base for the future design of immunotherapy, ge ne therapy and immuno-gene ther- apy.


    

本卷期目次
Therapeutic Radiology and Oncology
Study on Radiation Safety of High Dose Rate Multiple Cobalt-60 Sources Teletherapy Machine/ Sang-Hue YenYuh-Lin LeeLiung S. ChaoMax M. ChaoDavid HC PanKuang Y. Chen
Postoperative Low Dose Single Fraction Irradiation for Prevention of Heterotopic Bone Formation after Hip Surgery/ Le-Jung WuSang-Hue YenTain-Hsiung ChenLing-Wei WangKwan-Hwa ChiKuang Y. Chen
C型行為與癌的關系-癌症心理學書評-/ 陳光耀
Patterns of Pelvic Recurrence and Results of Salvage Treatment with Radiation Therapy for Recurrent Rectal Carcinoma/ Chong-Jong WangStephen Wan LeungHui-Chun ChenLi-Min SunFu-Min Fang
接受輻射治療之鼻咽腫瘤患者其視綱膜病變之評估/ 張東杰林淵謙陳墩祿楊克仁陳麗惠湯國政
西藏癌症與衛生醫療現況/ 顏上惠劉淑娟陳光耀
Curative Radiotherapy for Vocal Cord Carcinoma/ Weng Yih-ChyangJin-Ching LinJian-Sheng Jan
如何使用模擬攝影機之擋影托盤(shadow tray)确認擋塊位置/ 何聖佑鄭秀成雷德
Postoperative Radiotherapy for Malignant Gliomas/ Shyh-An YehStephen Wan LeungLi-Mm SunChong-Jong WangHuey-Jiun ChenFu-Min Fang
Results of Radiation Therapy for Regional Stage T4 Nasopharyngeal Carcinoma/ Chi-Yuan YehYuen-Liang LaiChang-Hung ChungKou-Hwa ChangYih-Cherng Lai
醫用直線加速器系統構造與保養作業簡介/ 李財福梁雲王重榮許順能黃置柔吳嘉明
維生素丙對鼷鼠放射線口腔黏膜炎修復與預防效應之研究/ 許文林黃經民任益民施榕平李恒昇李偉華
The Role of Epstein-Barr Virus Infection and the Immunocompetence of Patients with Nasopharyngeal Cancer/ Kuan-Chih ChowKuang Y. Chen
維生素丙對所鼷鼠放射線口腔黏膜炎修復與預防效應之研究/ 詩文林黃經民任益民施榕平李恆昇李偉華
Curative Radiotherapy for Vocal Cord Carcinoma/ Yih-Chyang WengJin-Ching LinJian-Sheng Jan
Results of Radiation Therapy for Regional Stage T4 Nasopharyngeal Carcinoma/ Chi-Yuan YehYuen-Liang LaiChang-Hung ChungKou-Hwa ChangYih-Cherng Lai
接受輻射治療之鼻咽腫瘤患者其視網膜病變之評估/ 張東杰林淵謙陳墩禄楊克仁陳麗惠湯國政
Postoperative Low Dose Single Fraction Irradiation for Prevention of Heterotopic Bone Formation after Hip Surgery/ Le-Jung WuSang-Hue YenTain-Hsiung ChenLing-Wei WangKwan-Hwa ChiKuang Y. Chen
Patterns of Pelvic Recurrence and Results of Salvage Treatment with Radiation Therapy for Recurrent Rectal Carcinoma/ Chong-Jong WangStephen Wan LeungHui-Chun ChenLi-Min SunFu-Min Fang
Postoperative Radiotherapy for Malignant Gliomas/ Shyh-An YehStephen Wan LeungLi-Min SunChong-Jong WangHuey-Jiun ChenFu-Min Fang
Study on Radiation Safety of High Dose Rate Multiple Cobalt-60 Sources Teletherapy Machine/ Sang-Hue YenYuh-Lin LeeLiung S. ChaoMax M. ChaoDavid HC PanKuang Y. Chen
The Role of Epstein-Barr Virus Infection and the Immunocompetence of Patients with Nasopharyngeal Cancer/ Kuan-Chih ChowKuang Y. Chen
如何使用模擬攝影機之擋影托盤(shadow tray)確認擋塊位置/ 何聖佑鄭秀成雷德
醫用直線加速器系統構造與保養作業簡介/ 李財福梁雲王重榮許順能黃置柔吳嘉明
西藏癌病與衛生醫療現況/ 顏上惠劉淑娟陳光耀
C型行為與癌的關係--癌症心理學書評--/ 陳光耀
 
   
 
   

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