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1
題名:腦垂體腺瘤之放射線治療     (14點)
Radiation Thearapy for Pituitary Adenoma
著者:戴于翔(Yu-Shyang Dai) ;賴允亮(Yuen-Liang Lai) ;鍾昌宏(Chang-Hung Chung) ;張國華(Kou-Hwa Chang) ;陳裕仁(Yu-Jen Chen) ;邵文逸(Wen-Yi Shau) ;黃昭源(Jau-Yuan Hwang)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:腦部腫瘤 ; 腦垂體腺瘤 ; 放射治療學 ; Brain neoplasm ; Pituitary adenoma ; Radiation therapy
刊名:放射治療與腫瘤學
頁碼:41-47
語言:繁體中文
摘要: 中文摘要PDF ; 英文摘要PDF

目的: 腦量體腺瘤的治療有三種基本方法, 合{井使用手術和放射治療常用於治療較大的臉瘤及腫瘤復發之救援。本文的目的在探討合併使用手術和放射治療的存活率,以及各種預後因子對存活率之影響。 材料與方法: 自1 9 8 3 至1 9 9 3 年間, 總計4 7 位經病種報告諸實為腦量體腺瘤的患者在馬偕紀念醫院接受放射線治療。其中共有2 5位男性及2 2位女性,年齡範團由2 1 至7 1歲( 中值為4 2 . 5鼓) 。最常見的症狀為視力障礙(伯72% )和頭痛(佔6 0%) 。放射線是經由6 MV 光子或鉛印射線, 每週照射5次,每次給予1 8 0 至2 0 0 cGy ( 中值為5 8 0 日cG y ) . 全部追蹤時間自2 至I I 年( 中值為5 . 6年) 結果: 4 7 位病人今成( A ) 及(B ) 兩組。(A ) 組有4 2 位愚者是接受非根除性手術後加上放射線治療,其中有4位中途失去追蹤、3位復發及5位死亡。死亡的原因有4位是因腫瘤壓迫,另|位為腦血管橫塞。平術後放射治療之5 年整體存活率為8 7 % .無復發存活率為9 3% 0 ( B) 組有5 位病人以放射線治療來處理手術後復發之腫瘤。其中的|位在1 2 4個月後因腫瘤壓迫致死,其餘4位情況正常。 壟墊: 利用l o g- r a n k te st 來分析預後因子, 發現年齡、性別及劑量對存活率影響之差異皆不具有統計學上意義。但整體而言﹒對於較大的腦垂體腺瘤,我們發現手術後加上放射線治療可得到不錯的腫瘤控制率﹒也許可以取代根除手術成為較大的腦愛體腺瘤之標準治療方法。
Aims: Patients with pit uitary adenoma ca n be man aged by three effective modes of treatments. Combi ned surgery and radi other ap y were used to treat pituitary macroadenoma and recurrent pituitary adenoma. The object of th is study wa s to investigate th e surviva l ra te and pr ogn osti c fa ct or s using combined surgery a nd radiot herapy. Materials and Methods : Between 1983 and 1993, 47 patien ts with pathologic all y pr oven pit iuitary adenoma received rad iation thera py at Mack a y Memor ial Hospital. Of th ese pa tients , 25 wer e mal es and 22 were females. The media n age was 42.5 years with a ra nge of 21 to 71 years. Visual disturbance (72%) and headache (60%) were the most commo n sympto ms. Ir radiat ion was delivered with 6-MV photo n or Co-60 gamma ray, 5 da ys per week, at a dose of 180 to 200 cGy per fracti on. T he total tumor dose ranged from 4140 cGy to 6500 cGy with a medi an dose of 5800 cGy. The follow-up period ra nged from 2 to 11 yea rs with a media n tim e of 5.6 yea rs. Results: 47 patients were divided into two gro ups by th ei r tumor status be fore ra di atio n therapy. Gro up A pa t ients, co nsisting of 42 patients we re und erwent incomplete resection a nd radiation th er apy as th e primary treatment. Among these patient s, 4 patients were lost during follow-up, and 3 patients ex per ienced recurrence of the tumor. Five pa t ients died during th e follow-up period, 4 patien ts for uncontrolled disea se and one pa tient for CVA. The ove ra ll S-yea r surv iva l rate was 87% and th e relap se-free surv iva l ra te wa s 93%. Gr oup (B) patient s, cansist ing of 5 patients were treated fo r recu rrence afte r surge ry . Of these patients, one died due to tumor compression 124 months a fter radiotherapy, but the remaining 4 cases are st ill doing well. Conclusions: Using the Log-ran k test, ge nder, age and dose a re not significant progn ostic fa ctor s. In br ief, we fou nd th at appropriate surgery and postopera t ive radi ati on th erapy could achi eve good local cont ro l and ma y repl ace radi cal surge ry as th e standard treatment for pit uitary macroadenoma.


    

本卷期目次
放射治療與腫瘤學
第二及第三期乳癌術後電子射線治療之結果/ 黃英彥梁雲王重榮陳惠君孫立民方富民
不同水流速度對假體內熱治療溫度分布之研究/ 熊佩韋許文林吳玉鈴蘇振隆施榕平
維生素C及Desmethylmisonidazole 對於CHO 細胞放射線效應之研究/ 許文林黃經民熊偑韋任益民盧昭元趙壯飛
Primary Malignant Fibrous Histiocytoma of The Breast a Case Report and Review of The Literature/ Wen-Haw SuMeng-Haw WuYuen-Liang LaiChang-Huang Chung
Combin Ation Radiotherapr and Chemotherapy for Organ Preserv Ation in Cancer Management/ Wing-Kai ChanKwan-Hwa ChiSang-Hue YenKuang Y. Chen
國立清華大學水池式反應器應用於硼中子捕捉治療的超熱中子束設計之現況/ 劉鴻嗚薛燕婉廖廷風朱惠珍開執中
Treatment Results of Laryngeal Cancer by Badiotherapy with or Without Surgery/ Louis Tak LuiSzu-Jung ChenLai-Lei TingPo-Ming WangNa-Na ChungChao-Yuan Huang
臺灣醫學物理現況與展望/ 黃英強
Prognostic Parameters in Malignant gliomas/ Jo-Ting TsaiYuen-Liang LaiChi-Yuan YehYu-Jen ChenWen-Yi ShauChang-Hung ChungKou-Hwa Chang
腦垂體腺瘤之放射線治療/ 戴于翔賴允亮鍾昌宏張國華陳裕仁邵文逸黃昭源
National Taiwan University Hospital Pilot Study of Chemoradiotherapy for Esophageal Carcinoma/ Louis Tak LuiChao-Yuan HuangLai-Lei TingPo-Ming WangNa-Na ChungSzu-Jung Chen
Combination Radiotherapy and Chemotherapy for Organ Preservation in Cancer Management/ Wing-Kai ChanKwan-Hwa ChiSang-Hue YenKuang Y. Chen
維生素C及Desmethylmisonidazole對於CHO細胞放射線效應之研究/ 許文林黃經民熊佩韋任益民盧昭元趙壯飛
Treatment Results of Laryngeal Cancer by Radiotherapy with or Without Surgery/ Louis Tak LuiSzu-Jung ChenLai-Lei TingPo-Ming WangNa-Na ChungChao-Yuan Huang
第二及第三期乳癌術後電子射線治療之結果/ 黃英彥梁雲王重榮陳惠君孫立民方富民
腦垂體腺瘤之放射線治療/ 戴于翔賴允亮鍾昌宏張國華陳裕仁邵文逸黃昭源
Prognostic Parameters in Malignant Gliomas/ Jo-Ting TsaiYuen-Liang LaiChi-Yuan YehYu-Jen ChenWen-Yi ShauChang-Hung ChungKou-Hwa Chang
National Taiwan University Hospital Pilot Study of Chemoradiotherapy for Esophageal Carcinoma/ Louis Tak LuiChao-Yuan HuangLai-Lei TingPo-Ming WangNa-Na ChungSzu-Jung Chen
不同水流速度對假體內熱治療溫度分布之研究/ 熊佩韋許文林吳玉鈴蘇振隆施榕平
國立清華大學水池式反應器應用於硼中子捕捉治療的超熱中子束設計之現況/ 劉鴻鳴薛燕婉廖廷風朱惠珍開執中
Primary Malignant Fibrous Histiocytoma of the Breast a Case Report and Review of the Literature/ Wen-Haw SuMeng-Haw WuYuen-Liang LaiChang-Hung Chung
學會專題研習 台灣醫學物理現況與展望/ 黃英強
 
   
 
   

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