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1
題名:Comparison of Clinical Outcome in Hypopharyngeal Cancer Treated with Radiotherapy Alone or Surgery Combined with Adjuvant Radiotherapy-10 Years, Experience in Mackay Memorial Hospital     (14點)
下咽癌接受單獨性放射線治療或手術合併術後放射線治療之臨床結果比較--馬偕醫院十年經驗
著者:Ming-Chih Wang(王銘志) ;Yi-Shing Leu(呂宜興) ;Kuo-Hwa Chang(張國華) ;Yuen-Laiang Lai(賴允亮) ;Chang-Hung Chung(鍾昌宏) ;Meng-Hao Wu(吳孟浩) ;Yu-Jen Chen(陳裕仁)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:下咽癌 ; 放射線治療 ; 手術 ; Hypopharyngeal cancer ; Radiotherapy ; Surgery
刊名:Therapeutic Radiology and Oncology
頁碼:253-259
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

且且: 針對下咽癌接受單獨性放射線治療或手術合併術後放射線治療, 評估其治療結果, 並分 析組織學上之預後因子。 材料且有注. 自1 9 8 7 年1 月至1 9 9 7 年1 2 月, 在本院接受單獨性放射線治療或手術合併術後放射線治療的8 1位下咽癌病患,作回溯性的分析,其中男性占79位,女性2位,年齡介於2 4至80歲(中間值5 4 ) 。其腫瘤第一期至四期分別為O . 3 • 2 2 及56 位, 這兩組病患之T期與N 一期分佈上並無明顯差異,其中1 8位病患接受單獨性放射線治療,每天1. 8 Gy . 放射線治療之平均劑量為6 3 . 9 Gy (介於3 4 . 2至7 5 . 6 Gy) . 男外6 3 位病患接受全喉切除術合併部分咽喉切除或食道切除術'這些病患皆接受輔助性放射線治療,平均劑量為6 0 . 4 Gy (介於3 6至73.8 Gy ) 。 益墨: 接受手術合併術後放射線治療之病患的5 年存活率為3 3 % .接受單獨性放射線治療病患的5年存活率為3 0 % ﹒這兩組存活率無明顯差異。接受手術合併術後放射線治療之病患的5年局部控制率為5 2 % .而接受單獨性放射線治療病患的5年局部控制率為4 0 % . 其有統計學上差異( P= O .O I 5 )。多因子分析確認神經侵犯與壞死為重要的預後因子。 益益﹒ 手術合併術後放射線治療比單獨性放射線治療有較好的局部控制率, 但對存活率無明顯差異,神經侵犯與壞死為有意義之預後因子。
Purnose: To evaluate treatment results and analyze pathological prognostic factors in surgery plus postoperative radiotherapy and radiotherapy alone for hypopharyngeal cancer. Materials and Methods: This retrospective analysis is based on the clinical outcome of 81 patients with hypopharyngeal cancer treated with surgery plus adjuvant radiotherapy and radiotherapy alone from January 1987 to December 1997. There were 79 males and 2 females, between 24 and 80 years old (median: 54). The numbers of patients in stages I to IV were 0, 3, 22 and 56, respectively. There were no significant difference in T- and N-distributions between the two treatment groups. Radiotherapy alone was used in 18 patients with 1.8 Gy pen fraction per day to a mean total dose of 63.9 Gy (range 34.2 to 75.6 Gy). Surgical treatment for 63 patients consisted of total laryngectomy with partial or total pharyngectomy and esophagectomy when indicated. These patients received adjuvant radiotherapy to a mean dose of 60.4Gy (range 36 to 73.8 Gy). Results: The 5-year survival rates were 33% for patients treated with surgery plus adjuvant radiotherapy and 30% for patients treated with radiotherapy alone. There was no significant difference in survival between the two treatment groups. The local control rate at 5 years was 52% for patients treated with surgery plus adjuvant radiotherapy, compared with 40% for patients treated with radiotherapy alone with a significant difference (p = 0.015). MUltivariate analysis identified that perineural invasion and necrosis are the significant predictors of poorer survival. Conclusion : The combi nation of surgery plus radiotherapy results in a better locoregional control than radiotherapy alone, but dose not yield a better survival. Perineural invasion and necrosis are associated with poorer survival.


    

本卷期目次
Therapeutic Radiology and Oncology
成人低惡性度顱內星狀細胞瘤之術後放射治療/ 張東杰容世明魏國珍曾振凎陳尚文
A Phase Ⅱ Study of Neoadjuvant Interferon Alfa-2B and Concurrent Interferon and Radiotherapy in Primary Untreated Undifferentiated Carcinoma of Nasopharynx/ Shen-Yen LinKwan-Hwa ChiChi-Kong LawSang-Hue Yen
The Role of Radiotherapy for Advanced Non-Small Cell Lung Cancer/ Shih-Che ChiuKou-Hwa ChangYu-Jen ChenChang-Hung ChungYuen-Liang LaiMeng-Hao Wu
攝護腺癌之傳統放射線治療—長庚紀念醫院十四年之經驗/ 陳妙芬陳文政梁為民張慧朗朱聖賢莊正鏗廖宗琦林永昌吳俊德洪志宏
三度空間電腦放射治療計劃系統之驗收與測試/ 林盈釧吳簡坤黃英強簡哲民
Comparison of Clinical Outcome in Hypopharyngeal Cancer Treated with Radiotherapy Alone or Surgery Combined with Adjuvant Radiotherapy- 10 Years, Experience in Mackay Memorial Hospital/ Ming-Chih WangYi-Shing LeuKuo-Hwa ChangYuen-Lainag LaiChang-Hung ChungMeng-Hao WuYu-Jen Chen
Study of Treatment Variation in the Radiotherapy of Pelvic Tumors Using a New Custom-Made Immobilization Cast and On-Line Electronic Portal Imaging/ Wen-Cheng ChenJr-Wei HerJami-Yi YehChien-Sung Hungshuo-Shung HungYuan-Chian LinNgan-Ming TsangWai-Man LeungSimon G. TangJi-Hong HongRobter TanChung-Chi Lee
Preoperative Radiotherapy in Patients with Lower Rectal Cancer: Results of Sphincter-Preservation, Treatment Outcome and Morbidities/ Shyh-An YehHong-Hwa ChenChong-Jong WangTsung-Min LinEng-Yen HuangChing-Yeh Hsiung
電子射束遮擋照野之劑量特性/ 林賢岳黃旼儀湯人仰黃英明黃志仁何耀輝郭珍妮
肝癌治療核醫藥物[(上標 125)I/(上標 131)I]Iododeoxyuridine之合成與配方研究/ 王信二季匡華顏上惠陳富都周衛樂黃廣良魏孝萍丁幹
攝護腺癌之傅統放射線治療--長庚紀念醫院十四年之經驗/ 陳妙芬陳文政梁為民張慧朗朱聖賢莊正鏗廖宗琦林永昌吳俊德洪志宏
Preoperative Radiotherapy in Patients with Lower Rectal Cancer: Results of Sphincter-Preservation, Treatment Outcome and Morbidities/ Shyh-An YehHong-Hwa ChenChong-Jong WangTsung-Min LinEng-Yen HuangChing-Yeh Hsiung
Comparison of Clinical Outcome in Hypopharyngeal Cancer Treated with Radiotherapy Alone or Surgery Combined with Adjuvant Radiotherapy-10 Years, Experience in Mackay Memorial Hospital/ Ming-Chih WangYi-Shing LeuKuo-Hwa ChangYuen-Laiang LaiChang-Hung ChungMeng-Hao WuYu-Jen Chen
A Phase Ⅱ Study of Neoadjuvant Interferon Alfa-2B and Concurrent Interferon and Radiotherapy in Primary Untreated Undifferentiated Carcinoma of Nasopharynx/ Shen-Yeh LinKwan-Hwa ChiChi-Kong LawSang-Hue Yen
成人低惡性度顱內星狀細胞瘤之術後放射治療/ 張東杰容世明魏國珍曾振凎陳尚文
The Role of Radiotherapy for Advanced Non-Small Cell Lung Cancer/ Shih-Che ChiuKou-Hwa ChangYu-Jen ChenChang-Hung ChungYuen-Liang LaiMeng-Hao Wu
肝癌治療核醫藥物[125Ⅰ/131Ⅰ]Iododeoxyuridine之合成與配方研究/ 王信二季匡華顏上惠陳富都周衛樂黃廣良魏孝萍丁幹
Study of Treatment Variation in the Radiotherapy of Pelvic Tumors Using a New Custom-Made Immobilization Cast and On-Line Electronic Portal Imaging/ Wen-Cheng ChenJr-Wei HerJami-Yi YehChien-Sung Hungshuo-Shung HungYuan-Chian LinNgan-Ming TsangWai-Man LeungSimon G. TangJi-Hong HongRobert TanChung-Chi Lee
三度空間電腦放射治療計劃系統之驗收與測試/ 林盈釧吳簡坤黃英強簡哲民
電子射束遮擋照野之劑量特性/ 林賢岳黃旼儀湯人仰黃英明黃志仁何耀輝郭珍妮
 
   
 
   

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