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dvdDiy扣件原住民教育困境OTA
   
   
   
     
   
 
項次 書目
1
題名:Definitive Radiotherapy with or Without Chemotherapy for Resectable Head and Neck Cancer     (14點)
使用放射治療或合併化學治療之方式治療可切除之頭頸部腫瘤
著者:Jason Chia-Hsien Cheng(成佳憲) ;Skye Hongiun Cheng(鄭鴻鈞) ;James Jer-Min Jian(簡哲民) ;Lawrence K. Yen(閻愷正) ;Kwan-Yee Chan(詹光裕) ;Cheng-I Hsieh(謝政毅)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:可切除之頭頸部腫瘤 ; 放射治療 ; 化學治療 ; 合併治療 ; Resectable head and neck cancers ; Radiotherapy ; Chemotherapy ; Concurrent
刊名:Therapeutic Radiology and Oncology
頁碼:33-39
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

且且. 回顧性分析以放射治療或合併化學治療之方式治療可切除之頭頸部腫瘤的可行性、治療副作用及存活率。 材料且有活: 三十位診斷為可切除之頭頸部腫瘤病人接受根治性放射治療或合併化學治療。一位病人為第一期,四位第二期,三位第三期,二十二位第四期疾病。放射治療為一日一次或一日兩次, 總劑量為6 8 - 7 4Gy 。化學治療使用C D D P 與5 -FU ' 包括兩次放射治療中的合併治療,與兩次放射治療後的治療。以Kaplan-Meie r method 分析存活率, 以log-rank test 分析預後因子。 誼星: 追踩時間之中位數為5 0 . 8 個月。四年整體存活率、無病存活率及局部控制率分別為5 5 . 7% 、64 .9% 及75 .8% 。治療相關的副作用屬可忍受。Tl月2 腫瘤的病人在統計上具有意義的較佳局部控制率(p = 0.0 3 ) 。治療結束後的核磁共振或電腦斷層檢查中若有殘存疾病的病人, 真統計上有意義的較差整體存活率( p = 0 .0 5 ) 、無病存活率( p = 0 .009 ) 及局部無再發存活率( p =0 . 0 0 0 1) 。 益益: 放射治療或合併化學治療之方式治療可切除之頭頸部腫瘤可考慮為根除手術外的一種選擇。它真有可接受的治療相關副作用及存活率。治療結束後的核磁共振或電腦斷層檢查中若有殘存疾病的病人,應接受進一步探查與治療。
Purpose: To retrospectively analyze the feasib ility, toxicity and outcome of definitive radiotherapy with or without chemotherapy for patients with resectable head and neck cancers. Materials and Methods: Thirty patients with resectable head and neck cancers were treated with definitive split-course radiotherapy with or without concurrent chemotherapy. One patient had stage I, 4 stage II, 3 stage III and 22 stage IV diseases. Radiotherapy was given once daily or twice daily with total dose of 68-74 Gy. Chemotherapy included 2 cycles with CDDP+/-5FU during radiotherapy. and 2 cycles with CDDP+5FU after radiation treatment. Survival outcome was calculated by the Kaplan-Meier method. Prognostic factors were determined by log-rank test. Results: The median follow-up time was 50.8 months. The 4-year overall survival, disease- free survival and locoregional control rates were 55.7%, 64.9% and 75.8%, respectively. Treatment-related toxicities were tolerable. T11T2 diseases were associated with better locoregional control (p= 0.03). The presence of residual disease on post-treatment MRI or CT was the prognostic factor for overall survival (p= 0.05), disease-free survival (p= 0.009) and locoregional recurrence-free survival (p= 0.0001). Conclusion: Definitive radiotherapy with or without chemotherapy can be an alternative to radical surgery for patients with resectable head and neck cancers, with acceptable toxicity and outcome. The presence of residual disease on post-treatment imaging studies demands further investigation and possibly salvage treatment.


    

本卷期目次
Therapeutic Radiology and Oncology
Treatment Results of Polymorphic Reticulosis at Veterans General Hospital-Taipei/ Hsi-Sheng ChsiaMien-Jung LiangYuk-Wah TsangChih-Hung ShuWing-Yin LeeKwan-Hwa ChiKuang-Yao ChenJing-Yi ChaoSang-Hue Yen
Definitive Radiotherapy with or Without Chemotherapy for Resectable Head and Neck Cancer/ Jason Chia-Hsien ChengSkye Hongiun ChengJames Jer-Min JianLawrence K. YenKwan-Yee ChanCheng-I Hsieh
遠隔治療機之屏蔽輻防安全評估/ 林招膨林松彥劉慕台朱鐵吉
Assessment of Dose Perturbation Due to Air Cavity Effects under Megavoltage Photon Beams/ Ji-An LiangFang-Jen LinAn-Cheng ShiauCheng-Pang TuHsieh-Ting WuShih-Neng YangShang-Wen Chen
Effect of Vitamin E on Arylamine N-Acetyltransferase Activity in Colon Cancer Tissues/ Chi-Fu HungJin-Gung ChungChih-Chung SuSu-Ing LiuJen LiaoMiki KiyokawaHygeia Hung
Effects of Cobalt-60 Irradiation on Trabecular Bone/ Chung ShihChih-Chuan TengMei-Yueh HuangJing-Min Hwang
侵犯性上泌尿道移形上皮細胞癌之治療/ 胡渝昌劉文山葛魯蘋林立青陳建勳張慶雄
Dose-Volume Analysis for 4 Patients with Radiation-Induced Liver Disease after 3-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma/ Jason Chia-Usien ChengtJian-Kuen WuJones Chao-Ming HuangSkye Hongiun ChengDavid HuangJames Jer-Min JianPo-Sheng Yang
鼻咽癌放射治療後皮膚溼性脫屑的處理與分析/ 陳玉萍曾雁明洪志宏湯國政曾振淦陳文政
Effect of Vitamin E on Arylamine N-Acetyltransferase Activity in Colon Cancer Tissues/ Chi-Fu HungJin-Gung ChungChih-Chung SuSu-Ing LiuJen LiaoMiki KiyokawaHygeia Hung
侵犯性上泌尿道移形上皮細胞癌之治療/ 胡渝昌劉文山葛魯蘋林立青陳建勳張慶雄
Treatment Results of Polymorphic Reticulosis at Veterans General Hospital-Taipei/ Hsi-Sheng ChsiaMien-Jung LiangYuk-Wah TsangChih-Hung ShuWing-Yin LeeKwan-Hwa ChiKuang-Yao ChenJing-Yi ChaoSang-Hue Yen
Definitive Radiotherapy with or Without Chemotherapy for Resectable Head and Neck Cancer/ Jason Chia-Hsien ChengSkye Hongiun ChengJames Jer-Min JianLawrence K. YenKwan-Yee ChanCheng-I Hsieh
鼻咽癌放射治療後皮膚溼性脫屑的處理與分析/ 曾雁明洪志宏湯國政曾振淦陳文政
Assessment of Dose Perturbation Due to Air Cavity Effects under Megavoltage Photon Beams/ Ji-An LiangFang-Jen LinAn-Cheng ShiauCheng-Pang TuHsieh-Ting WuShih-Neng YangShang-Wen Chen
Dose-Volume Analysis for 4 Patients with Radiation-Induced Liver Disease after 3-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma/ Jason Chia-Hsien ChengJian-Kuen WuJones Chao-Ming HuangSkye Hongiun ChengDavid HuangJames Jer-Min JianPo-Sheng Yang
遠隔治療機之屏蔽輻防安全評估/ 林招膨林松彥劉幕台朱鐵吉
Effects of Cobalt-60 Irradiation on Trabecular Bone/ Chung ShihChih-Chuan TengMei-Yueh HuangJing-Min Hwang
 
   
 
   

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