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題名:Dose-Volume Analysis for 4 Patients with Radiation-Induced Liver Disease after 3-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma     (14點)
四例肝細胞癌病人接受三度空間隨形放射線治療後發生放射線引起之肝病變的劑量--體積分析
著者:Jason Chia-Hsien Cheng(成佳憲) ;Jian-Kuen Wu(吳簡坤) ;Jones Chao-Ming Huang(黃昭明) ;Skye Hongiun Cheng(鄭鴻鈞) ;David Huang(黃英強) ;James Jer-Min Jian(簡哲民) ;Po-Sheng Yang(楊博勝)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:肝細胞癌 ; 放射線治療 ; 放射線引起之肝病變 ; Hepatocellular carcinoma ; Radiotherapy ; Radiation-induced liver disease
刊名:Therapeutic Radiology and Oncology
頁碼:55-61
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

且且: 針對目前發表之幾種肝臟放射線治療後預測放射線引起之肝病變的機率模式, 評估其實用性與準確性。 材料且有注: 1994 年4 月至1998 年10 月, 四位肝細胞癌病人接受三度空間隨形放射線治療後,三個月內產生放射線引起之肝病變。四位病人治療前皆接受了電腦斷層模擬定位,且影像資訊均涵蓋整個肝臟。由劑量-體積關係圖中求得V30旬' V恥, Ve叮與P S 幾項參數, 再由幾種預測模式換算出產生放射線引起之肝臟病變機率。 益星: 四位發生放射線引起之肝病變病人中, 二位死於此併發症, 另二位復原。二位死於併發症的病人正常肝臟超過3 0 Gy 的體積均小於50% '而存活的二位病人超過3 0 Gy 的肝臟則大於50 % 。四位病人中的三位其放射線劑量皆符合密西根大學醫學中心依據VSO% 的建議劑量。依據正常組織併發症機率模式分析,若應用0 . 69為體積效應參數,四位病人的併發症機率均在加以下,若應用0 . 32為參數,則機率為5 -2 0 % 。 益益: 目前發表的幾種對放射線引起之肝病變的機率預測模式, 均不能準確評估台灣肝細胞癌病人接受放射線治療後的併發症機率。利用目前使用的放射治療療程設計及劑量-體積資料,建立一套適合台灣肝細胞癌病人併發症預測模式,是有其必要性的。
Purpose: To evaluate the feasibility and accuracy of the currently documented models for prediction of radiation -induced liver disease (RILD), for patients with hepatocellular carcinoma (HCC) treated with 3-dimensional conformal radiotherapy, Materials and Methods: From September 1994 to October 1998, four patients with HCC developed RILD within 3 months after complet ion of 3-dimensional conformal radiotherapy. All patients had CT simulation with the images including the entire liver. The detailed information from the dose-volume histogram (DVH), including V30Gy, VSO%, Ven and prediction score (PS), were calculated and assessed. The complication probabilities were compared with several documented models. Results: Two patients died of RILD-related hepatic failure and 2 recovered. Two patients had more than half of the liver with > 30 Gy survived but the other 2 patients died of RILD with 40% and 23% of the liver receiving > 30 Gy. Three of 4 patient had the recommended doses of radiation based on the calculated VSO%' According to the normal tissue complication probability (NTCP) model, the complication probabilities were less than 5% and within 5-20% if 0.69 and 0.32 were applied for the volume effect parameters, respectively. Conclusion: All the currently documented models fail to accurately estimate the probability of RILD for the 4 patients with HCC treated with 3-dimensional conformal radiotherapy. It is indicated to establish a model for patients with HCC in Taiwan, using the currently available fractionation and the information from the DVH.


    

本卷期目次
Therapeutic Radiology and Oncology
侵犯性上泌尿道移形上皮細胞癌之治療/ 胡渝昌劉文山葛魯蘋林立青陳建勳張慶雄
Assessment of Dose Perturbation Due to Air Cavity Effects under Megavoltage Photon Beams/ Ji-An LiangFang-Jen LinAn-Cheng ShiauCheng-Pang TuHsieh-Ting WuShih-Neng YangShang-Wen Chen
遠隔治療機之屏蔽輻防安全評估/ 林招膨林松彥劉慕台朱鐵吉
Dose-Volume Analysis for 4 Patients with Radiation-Induced Liver Disease after 3-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma/ Jason Chia-Usien ChengtJian-Kuen WuJones Chao-Ming HuangSkye Hongiun ChengDavid HuangJames Jer-Min JianPo-Sheng Yang
Treatment Results of Polymorphic Reticulosis at Veterans General Hospital-Taipei/ Hsi-Sheng ChsiaMien-Jung LiangYuk-Wah TsangChih-Hung ShuWing-Yin LeeKwan-Hwa ChiKuang-Yao ChenJing-Yi ChaoSang-Hue Yen
Definitive Radiotherapy with or Without Chemotherapy for Resectable Head and Neck Cancer/ Jason Chia-Hsien ChengSkye Hongiun ChengJames Jer-Min JianLawrence K. YenKwan-Yee ChanCheng-I Hsieh
鼻咽癌放射治療後皮膚溼性脫屑的處理與分析/ 陳玉萍曾雁明洪志宏湯國政曾振淦陳文政
Effect of Vitamin E on Arylamine N-Acetyltransferase Activity in Colon Cancer Tissues/ Chi-Fu HungJin-Gung ChungChih-Chung SuSu-Ing LiuJen LiaoMiki KiyokawaHygeia Hung
Effects of Cobalt-60 Irradiation on Trabecular Bone/ Chung ShihChih-Chuan TengMei-Yueh HuangJing-Min Hwang
Effect of Vitamin E on Arylamine N-Acetyltransferase Activity in Colon Cancer Tissues/ Chi-Fu HungJin-Gung ChungChih-Chung SuSu-Ing LiuJen LiaoMiki KiyokawaHygeia Hung
侵犯性上泌尿道移形上皮細胞癌之治療/ 胡渝昌劉文山葛魯蘋林立青陳建勳張慶雄
Treatment Results of Polymorphic Reticulosis at Veterans General Hospital-Taipei/ Hsi-Sheng ChsiaMien-Jung LiangYuk-Wah TsangChih-Hung ShuWing-Yin LeeKwan-Hwa ChiKuang-Yao ChenJing-Yi ChaoSang-Hue Yen
Definitive Radiotherapy with or Without Chemotherapy for Resectable Head and Neck Cancer/ Jason Chia-Hsien ChengSkye Hongiun ChengJames Jer-Min JianLawrence K. YenKwan-Yee ChanCheng-I Hsieh
鼻咽癌放射治療後皮膚溼性脫屑的處理與分析/ 曾雁明洪志宏湯國政曾振淦陳文政
Assessment of Dose Perturbation Due to Air Cavity Effects under Megavoltage Photon Beams/ Ji-An LiangFang-Jen LinAn-Cheng ShiauCheng-Pang TuHsieh-Ting WuShih-Neng YangShang-Wen Chen
Dose-Volume Analysis for 4 Patients with Radiation-Induced Liver Disease after 3-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma/ Jason Chia-Hsien ChengJian-Kuen WuJones Chao-Ming HuangSkye Hongiun ChengDavid HuangJames Jer-Min JianPo-Sheng Yang
遠隔治療機之屏蔽輻防安全評估/ 林招膨林松彥劉幕台朱鐵吉
Effects of Cobalt-60 Irradiation on Trabecular Bone/ Chung ShihChih-Chuan TengMei-Yueh HuangJing-Min Hwang
 
   
 
   

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