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1
題名:Effect of Lomustine on N-Acetyltransferase Activity in Rat Glioma in Vitro Cultured Cells     (12點)
Lomustine對大白鼠神經膠質瘤之體外培養細胞中乙醯轉移酶活性的影響
著者:Chih-Chung Su(蘇志中) ;Miki Kiyokawa(廖美姬) ;Jen Liao(廖仁) ;Chi-Wen Kao(郭啓文) ;Ming-Tsuen Hsieh(謝明村) ;Jin-Gung Chung(鍾景光) ;Chi-Fu Hung(洪啓賦)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:芳香胺化合物 ; N基乙醯轉酶 ; 神經膠質細胞瘤 ; Arylamine ; N-acetyltransferase ; Glioma ; Lomustine
刊名:Therapeutic Radiology and Oncology
頁碼:9-14
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

且且: 芳香胺化合物經N 基乙醋轉移晦( N-acetyltransferase )之N基乙臨化可誘發癌, lomustine是常用於治療腦瘤的一種抗癌物藥, 本研究是in vitro 探討lomustin e 對大白鼠神經膠質細胞瘤之體外培養細胞中乙醋轉移晦活性的影響。 材料坦克海: 取大白鼠神經膠質細胞瘤之體外培養細胞( n = 12 ) 用乙醋化輔臨A 作乙醋基而再利用高壓液相層析儀分析乙瞌轉移醋的活性及lo mu s tine對大白鼠神經膠質細胞瘤之體外培養細胞中乙臨轉移酪活性的影響, 以2 -amin o f1u o r e n e ( 2-AF ) 和p-amin o b e n zo i c acid (PABA) 作受質。 益星: 結果顯示大白鼠神經膠質細胞瘤之體外培養細胞對AF 及PABA 受質皆有乙臨轉移臨活性存在,其對M及PABA 的活性平均值各為1. 0 8 ± 0 .18 及0.96 ± 0.16 nmoVminjmg protein 。在0 . 8 μ M, 8μM and 80μM 的lomustine濃度中, 大白鼠神經膠質細胞瘤之體外培養細胞中AF-NAT活性降低約1 7 恥, 3 1. 5 % and 45 .4%, PABA-NAT 活性降低約10 .4 % , 27 .1%and 4 5 .8% 。 誼通Lomu stin e 可降低大白鼠神經膠質細胞瘤之體外培養細胞中乙醋轉移醋的活性。
Purpose: Arylamine N-acetylation capacity by the N-acetyltransferase (NAT) may be an important causative factor in the initiation of cancer. Lomustine is a commercially available nitrosourea derivative and chloroethyl nitrosourea compound which applied in antineoplastic therapy especially in central nervous system. The affect of lomustine on the activity of NAT in rat glioma in vitro cultured cells were investigated. Materials and Methods: Rat glioma in vitro cultured cell cytosol (n=12) were used to investigate for the effect of lomustine on the activity of NAT toward 2-amniofluorene (AF) and p-aminioben zoic acid (PABA) using an acetyl coenzyme A (AcCoA) recycling assay and high pressure liquid chromatography (HPLC). Results: Activity of N-acetyltransferase in rat glioma in vitro cultured cell cytosol is found to be inhibited by lomustine. Its presence in the assay medium shows an inhibition in aminofluorene-N-acetyltransferase (AF-NAT) activ ity about of 17.6%, 31.5% and 45.4% in rat glioma in vitro cultured cells at 0.8 IJM, 8 IJM and 80 IJM of lomustine concentrations respectively; while as p-aminobenzoic acid-N-acetyltransfe rase (PABA-NAT) activity decreased about 10.4%, 27.1% and 45.8% in rat glioma cells with 0.8 IJM, 8 IJM and 80(M of lomustine concentrations respectively. Conclusion : The results of this study show that the NAT activity of rat glioma cultured cells are decreased by lomustine.


    

本卷期目次
Therapeutic Radiology and Oncology
根據TG-51議定書以不同游離腔量測直線加速器電子輸出劑量之比較/ 林招膨林桂華朱鐵吉劉幕台黃勝賢張雅婷黃昭源
放射線照射及BSO處理後多形性神經膠母瘤細胞內麩氨基硫含量變化之研究/ 黃經民黃旭山許文林熊佩韋李偉華
Effect of Lomustine on N-Acetyltransferase Activity in RAT Glioma in Vitro Cultured Cells/ Chih-Chung SuMiki KiyokawaJen-LiaoChi-Wen KaoMing-Tsuen HsiehJin-Gung ChungChi-Fu Hung
全身照射治療的劑量測定與兩側平行對照技術的應用/ 吳簡坤林盈釧郭祥吉吳東和黃英強陳志成蔡玉真成佳憲簡哲民
成人軟組織肉瘤病人之術後輔助性放射治療/ 簡君儒陳尚文謝長堯黃昭源林芳仁
全身皮膚電子束放射治療之劑量學/ 謝忠志戴宏旗陳弘政奚正義張國華賴允亮吳孟浩
Hodgkin's Disease, Changing Pattern of Histology Subgroup and AGE Distribution, VGH-Taipei's Experience with 240 Cases over 26 Years--1970 to 1995/ Chung-Yih WangJing-Yi ChaoShan-Huei Yen
臨床劑量測定方法的最新發展-TG-51議定書/ 鄭秀成李俊信陳君德曾鑠鑠雷德張幗孫
放射線照射及BSO處理後多形性神經膠母瘤細胞內麩氨基硫含量變化之研究/ 黃經民黃旭山許文林熊佩韋李偉華
成人軟組織肉瘤病人之術後輔助性放射治療/ 簡君儒陳尚文謝長堯黃昭源林芳仁
Hodgkin's Disease, Changing Pattern of Histology Subgroup and Age Distribution, VGH-Taipei's Experience with 240 Cases Over 26 Years-1970 to 1995/ Chung-Yih WangJing-Yi ChaoShan-Huei Yen
全身照射治療的劑量測定與兩側平行對照技術的應用/ 吳簡坤林盈釧郭祥吉吳東和黃英強蔡玉真成佳憲簡哲民
全身皮膚電子束放射治療之劑量學/ 謝忠志戴宏旗陳弘政奚正義張國華賴允亮吳孟浩
臨床劑量測定方法的最新發展--TG-51議定書/ 鄭秀成李俊信陳君德曾鑠鑠雷德張幗孫
根據TG-51議定書以不同游離腔量測直線加速器電子輸出劑量之比較/ 林招膨林桂華朱鐵吉劉幕台黃勝賢張雅婷黃昭源
Effect of Lomustine on N-Acetyltransferase Activity in Rat Glioma in Vitro Cultured Cells/ Chih-Chung SuMiki KiyokawaJen LiaoChi-Wen KaoMing-Tsuen HsiehJin-Gung ChungChi-Fu Hung
 
   
 
   

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