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1
題名:AN EFFECTIVE, EFFICIENT AND SAFE METHOD TO DELIVER A MODIFIED 3-D RADIOTHERAPY IN LOCALLY ADVANCED NASOPHARYNGEAL CARCINOMA     (18點)
局部嚴重侵犯鼻咽癌的一種有效率及安全的三度空間放射治療計劃
著者:Yih-Lin Chung(鍾邑林) ;Skye Hon-Giun Cheng(鄭鴻鈞) ;Stella Y. C. Tsai(蔡玉真) ;Jason C. Cheng(成佳憲) ;Shu-Li Kang(康淑娌) ;James Jer-Min Jian(簡哲民)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:鼻咽癌 ; 多分次放射線治療 ; Nasopharyngeal carcinoma ; DVH ; Hyperfractionation radiotherapy
刊名:Therapeutic Radiology and Oncology
頁碼:137-145
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

且且: 設計一種改良式的三度空間放射治療計劃, 不僅容易執行, 減少腦幹照射, 且仍可給予局部嚴重侵犯的鼻咽癌足夠劑量。 材剝血有注: 本研究選擇腫瘤侵犯靠近腦幹而無遠處轉移的T4鼻咽癌病人為此種治療計劃的標的。此計畫的設計乃藉由CM S - F o c u s 之軟體系統,並經由西門子公司之加速器來執行口治療計劃的可行性是以執行的容易度,要求劑量分佈之達成度,腫瘤及正常組織之DVH 和IM R T及3 DCRT 之比較, 潛在輻射生物的效果和同步化學治療之毒性來評估。其治療結果之確定乃比較治療前後之核磁共振和核醫檢查之影像。 輯是:此治療計劃每次只需執行2 至4 照野即可, 最終達到腫瘤致死劑量而正常組織所接受的劑量仍在正常範圍內,腫瘤之DVH 相似於IM RT之結果, 而正常組織之D VH 則相似於3 DCRT之結果, 在腫瘤密度愈大之區,其所受劑量之愈高, 而正常組織內並無熱點( h ot spot ) , 即使台併同步化學治療,病人仍可耐受而無重大毒性。藉由治療完成後的第三個月的核磁共振及核子醫學的掃描影像,證實腫瘤完全消失D 益益:此改良式的三度空間放射治療是一有效率及安全的方法, 可以有效的治療局部嚴重侵犯的鼻咽癌, 但仍需長期追蹤觀察,以確立臨床上之真正益處。
Purpose : To generate a modified 3-D radiotherapy planning that can be delivered easily and safely, and treat the targets adequately in locally advanced nasopharyngeal carcinoma. Materials and Methods : The stage T4 NPC patients without distant metastasis, especially with a huge tumor approaching or close to the brain stem, were selected for this treatment planning under curative intent. The CMS-FOCUS planning system was used to generate these 3-D radiotherapy plans. The plans were evaluated with respect to daily treatment time and ease of treatment delivery, achievement of dose requirement to tumor with normal tissue sparing, dose-volume histograms of gross target volume and critical normal structures, potential radiobiological effects and toxicity of concurrent chemotherapy. The treatment responses were defined by the serial follow-up MRI and Tc-99m nuclear scans. Results : Each time only 2-4 portals were needed to deliver a tumoricidal dose (200 cGy once a day to 7000 cGy, or 120 cGy twice a day to 7440 cGy) to 100% of the primary tumor target volume while still keeping the doses of the adjacent critical normal structures within safety limits. The DVH of GTV is similar to that of IMRT but the DVHs of spinal cord and mandible are similar to those of 3DCRT. The highest dose was centered to the heavy tumor burden area. There was no any hot spot in normal tissue. This treatment was well tolerated and showed only moderate toxicity, even with concurrent chemotherapy. The complete response was confirmed by serial MRI and Tc-99m nuclear scans after treatment. Conclusion : This modified 3-D radiotherapy was effective, efficient, and safe in treating locally advanced nasopharyngeal carcinoma. Longer follow-up and more patients are needed to establish the true clinical advantage


    

本卷期目次
Therapeutic Radiology and Oncology
Primary Central Nervous system Lymphoma - 3 Cases Report/ Chi-Fu HungJyh-Der LeuChien-Ru Liu
電腦輔助設計三度空間真實表面數學模式於放射治療定位影像之應用/ 吳錦榕孫述平許文林阮昭銘
Radiotherapy of Conjunctival Lymphoma with A Specially Designed Lens Block/ Wei-Chung HsuLai-Lei TingShiu-Chen JengPo-Ming WangLouis Lui TakSzu-Jong ChenNa-Na ChungGau-De Lin
放射治療機加值型網路劑量品質保證系統/ 劉雪君張淑瓊趙良曉李玉麟顏上惠
Fractiona Stereotactic Radiotherapy for Malignant Glioma/ Tao-Sang ChungJeng-Fong ChiouChung-Yu KaoJo-Ting TsaiChi-Yuan YehChi-Ching LoPing-Ling ChenWen-Ta Chiou
Radiotherapy is Effective in the Treatment of Hepatocellular Carcinoma with Right Atrium Invasion - Report of A Case/ Chih-Ping ChenYee ChaoChung-Pin LiMing-Yu LaiKwan-Hwa ChiSang-Hue YenFull-Young ChangShou-Dong Lee
利用氣泡偵檢器量測醫用直線加速器光中子研究/ 林招膨林松彥朱鐵吉劉幕台張東浩黃昭源
An Effective, Efficient and Safe Method to Deliver A Modified 3-D Radiotherapy in Locally Advanced Nasopharyngeal Carcinoma/ Yih-Lin ChungSkye Hon-Giun ChengStella Y.C. TsaiJason C. ChengShu-Li KangJames Jer-Min Jian
Alveolar Soft Part Sarcoma: Clinical Outcome of Two Patients and Review of the Literature/ Helen H.W. ChenFen-Fen ChenWen-Tsung HuangLi-Li ChengHenry W.C. Leung
不同骨盆腔固定器在攝護腺癌三度空間立體順形放射治療技術之評估/ 賴朝宗劉裕明吳曉萍蕭正英李玉麟季匡華顏上惠
AN EFFECTIVE, EFFICIENT AND SAFE METHOD TO DELIVER A MODIFIED 3-D RADIOTHERAPY IN LOCALLY ADVANCED NASOPHARYNGEAL CARCINOMA/ Yih-Lin ChungSkye Hon-Giun ChengStella Y. C. TsaiJason C. ChengShu-Li KangJames Jer-Min Jian
FRACTIONATED STEREOTACTIC RADIOTHERAPY FOR MALIGNANT GLIOMA/ Tao-Sang ChungJeng-Fong ChiouChung-Yu KaoJo-Ting TsaiChi-Yuan YehChi-Ching LoPing-Ling ChenWen-Ta Chiou
RADIOTHERAPY OF CONJUNCTIVAL LYMPHOMA WITH A SPECIALLY DESIGNED LENS BLOCK/ Wei-Chung HsuLai-Lei TingShiu-Chen JengPo-Ming WangLui Louis TakSzu-Jong ChenNa-Na ChungGau-De Lin
電腦輔助設計三度空間真實表面數學模式於放射治療定位影像之應用/ 吳錦榕孫述平許文林阮昭銘
不同骨盆腔固定器在攝護腺癌三度空間立體順形放射治療技術之評估/ 賴朝宗劉裕明吳曉萍蕭正英李玉麟季匡華顏上惠
利用氣泡偵檢器量測醫用直線加速器光中子研究/ 林招膨林松彥朱鐵吉劉幕台張東浩黃昭源
放射治療機加值型網路劑量品質保證系統/ 劉雪君張淑瓊趙良曉李玉麟顏上惠
PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA-3 CASES REPORT/ Chi-Fu HungJyh-Der LeuChien-Ru Liu
ALVEOLAR SOFT PART SARCOMA: CLINICAL OUTCOME OF TWO PATIENTS AND REVIEW OF THE LITERATURE/ Helen H. W. ChenFen-Fen ChenWen-Tsung HuangLi-Li ChengHenry W. C. Leung
RADIOTHERAPY IS EFFECTIVE IN THE TREATMENT OF HEPATOCELLULAR CARCINOMA WITH RIGHT ATRIUM INVASION-REPORT OF A CASE/ Chih-Ping ChenYee ChaoChung-Pin LiMing-Yu LaiKwan-Hwa ChiSang-Hue YenFull-Young ChangShou-Dong Lee
 
   
 
   

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