原名「台灣學術線上」
包含TAO期刊庫 + TAO書籍庫 + 論文 + 史料文獻
首頁 | 關於TAO | 瀏覽 | 進階查詢 | 參考工具 | 會員服務 | 已購專書 | RSS服務 | 電子報 | FAQ  
查詢範圍:
   
查詢模式:
熱門查詢詞:
dvdDiy扣件原住民教育困境資優生
   
   
   
     
   
 
項次 書目
1
題名:THE IMPACT OF DYNAMIC PAROTID VOLUME CHANGES AND BODY WEIGHT LOSS ON DOSE DISTRIBUTIONS FOR PATIENTS WITH NASOPHARYNGEAL CANCER RECEIVING INTENSITY-MODULATED RADIATION THERAPY     (22點)
腮腺體積變化和體重減輕對於鼻咽癌病患接受強度調控放射治療劑量分布的影響
著者:Chia-Hsuan Lai(賴家玄) ;Miao-Fen Chen(陳妙芬) ;Chao-Hsiung Hung(洪照雄) ;Kuo-Chi Liu(劉國基) ;Wen-Hung Wang(王文弘) ;Wen-Cheng Chen(陳文政)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:鼻咽癌 ; 強度調控放射治療 ; 腮腺 ; 體重減輕 ; 放射治療計畫 ; Nasopharyngeal neoplasm ; Intensity-modulated radiotherapy ; Parotid gland ; Weight loss ; Radiotherapy planning
刊名:Therapeutic Radiology and Oncology
頁碼:113-123
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:對於鼻咽癌而言,強度調控放射治療已成為具展望的新治療方法,可以提供良好的腫瘤 包覆並且有意義的保留腮腺的功能。本研究目的在於量化對於顯著的體重減輕與否對腮腺體積 的縮小的影響以及腮腺體積的縮小對於腮腺的劑量分布的影響。 材料與方法:從 2003 年 2 月到 2005 年 10 月,共收集了30 個病人。13 個病人有顯著的體重 減輕。在每個病人接受的劑量到達41.4 Gy 到46.8 Gy 的時候,會讓病人再做一次電腦斷層模擬 攝影,獲得第二組用來做治療計畫的電腦斷層影像,做出第二個強度調控放射治療的治療計畫 (新治療計畫)。另外,在假設沒有第二組用來做治療計畫的電腦斷層影像的情形之下,對於 原來的電腦斷層影像,我們也會做出另一個治療計畫(新混合型治療計畫)。 結果:病人身體輪廓的縮減和體重減輕有高度相關。不管體重有無顯著的減輕,腮腺體積都會 縮小。在比較“新治療計畫”和“新混合型治療計畫”的劑量分布之後,我們發現兩者在腫瘤 目標的包覆上並沒有顯著的劑量差異。但是在腦幹,脊髓以及兩側的腮腺則發現在新混合型治 療計畫有顯著的劑量增加。進一步分析發現,當病人體重有顯著的減輕時,脊髓,腦幹,右側 的腮腺及高劑量區在PTVCTV1 的比例則有顯著增加。當病人體重沒有顯著的減輕時,腦幹和脊 髓的劑量會增加但腫瘤的劑量包覆仍是符合要求的。 結論:腮腺體積在強度調控放射治療的過程中會有顯著的縮小,即使病人沒有顯著的體重減 輕。對於用強度調控放射治療來治療鼻咽癌,第二組電腦斷層影像以及新的治療計畫是需要 的。 [ 放射治療與腫瘤學2010; 17(2): 113-123]
Background : Intensity-modulated radiation therapy (IMRT) has become the new promising treatment of nasopharyngeal cancer (NPC) in terms of providing excellent tumor coverage with significant sparing of the parotid glands. In this study, we intend to quantify the importance of the volume shrinkage of parotid gland and its influence on the dose distribution of parotid glands among patients with or without significant body weight loss. Material and Methods : From Feb. 2003 to Oct. 2005, 30 patients with NPC were enrolled into this study. 13 patients suffered from significant body weight loss (> 6% of their origin body weight at the end of the 4th week of the entire RT course). A 2nd plan CT scan images were acquired after every patient had received 41.4 to 46.8 Gy of prescribed dose. A second IMRT plan was generated for the cone-down treatment. However, we also created a 2nd plan (Hybrid 2nd plan) for the 1st CT images to assume if no 2nd plan CT images were available. Results : The reductions of body contours are highly correlated with the body weight loss of the patients. The parotid glands decrease in size no matter the patients had significant body weight loss or not. When comparing the dosimetric effects of Hybrid and New 2nd plan, there were no significant dosimetric differences of target coverage. However, increases in the doses of normal tissue such as brainstem, spinal cord, left and right parotid glands were noted. In the subgroup analysis, there were significant increase of spinal cord, brainstem, R’t parotid gland doses and hot spots in PTVCTV1 for patients with significant body weight loss. For patients without significant body weight loss, there were increases of spinal cord and brainstem doses but the target dose coverage remained satisfactory. Conclusions : We conclude that the volume of parotid glands decreased significantly during the course of IMRT even in patients without significant body weight loss. A 2nd plan CT and a new 2nd IMRT plan based on the new CT scan are needed for the IMRT treatment of NPC. [Therapeut Radiol Oncol 2010; 17(2): 113-123]


    

本卷期目次
Therapeutic Radiology and Oncology
PRELIMINARY RESULTS OF INTENSITY-MODULATED RADIOTHERAPY IN THE TREATMENT OF NASOPHARYNGEAL CARCINOMA/ You-Kang ChangJing-Min HwangChiou-Shiung ChangSemon Wu
THE IMPACT OF DYNAMIC PAROTID VOLUME CHANGES AND BODY WEIGHT LOSS ON DOSE DISTRIBUTIONS FOR PATIENTS WITH NASOPHARYNGEAL CANCER RECEIVING INTENSITY-MODULATED RADIATION THERAPY/ Chia-Hsuan LaiMiao-Fen ChenChao-Hsiung HungKuo-Chi LiuWen-Hung WangWen-Cheng Chen
利用影像導引放射治療技術來評估擺位誤差對於計劃靶體積包覆率的影響/ 劉義誠劉煥彰陳柏元陳臣苑張安進程言鼎曾雁明洪志宏
使用輻射變色膠片於卡波西氏肉瘤放射線治療的活體劑量驗證/ 溫嘉綺葉恬綺楊凱鈞許仲賢王雱儀吳任弘柯卉玲季匡華
SMALL CELL CARCINOMA OF EXTERNAL AUDITORY CANAL: A CASE REPORT/ Chia-Wei ShenYu-Chang HuWei-Ming LaiChien-Hsun ChenChung-Man LeungKuo-Chen ChangChing-Hsiung Chang
PULMONARY KAPOSI'S SARCOMA IN A PATIENT WITH HIV INFECTION: A CASE REPORT/ Tzu-Hwei WangYung-Hsiang HsuWen-Lin Hsu
ONCOCYTIC CARCINOMA OF THE SUBMANDIBULAR GLAND, FROM BENIGN TO MALIGNANT--A REPORT ON AN UNUSUAL CASE/ Jenny QueLi-Ching LinWen-Ying LeeKue-Li LinChia-Hui LinYu-Wei LinChing-Chieh Yang
LONG-TERM OUTCOMES OF RADIOTHERAPY FOR PRIMARY PEDIATRIC BRAIN TUMORS: STATISTICS AND STRATEGIES OF A SINGLE INSTITUTE IN TAIWAN/ Kai-Lin YangPin-I HuangTai-Tong WongKai-Ping ChangLing-Wei WangCheng-Ying ShiauYu-Ming LiuKeng-Li LanYu-Wen HuI-Chun LaiYi-Wei ChenSang Hue Yen
 
   
 
   

與TAO合作 | 隱私與版權聲明 | 聯絡方式 | 下載Adobe Reader
地址:台北市中正區(100)北平東路30-12號3樓
電話:(02)2393-6968 傳真:(02)2393-6877
Email: service@wordpedia.com
Wordpedia Family: 學校、企業版入口 | 遠流影音館
Copyright©2011 Wordpedia Co., Ltd. All Rights Reserved.