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題名:THE OUTCOME OF POSTOPERATIVE RADIOTHERAPY FOR ADENOID CYSTIC CARCINOMA OF THE HEAD AND NECK     (22點)
頭頸部腺樣囊狀癌手術後放射治療結果分析
著者:Chien-Chih Chen(陳建志) ;Jin-Ching Lin(林進清) ;Jian-Sheng Jan(詹建勝)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:腺樣囊狀癌 ; 頭頸部 ; 放射治療 ; 手術 ; Adenoid cystic carcinoma ; Head and neck ; Radiotherapy ; Surgery
刊名:Therapeutic Radiology and Oncology
頁碼:189-199
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:分析頭頸部腺樣囊狀癌手術後輔助放射線治療的長期結果。 材料與方法:本回溯性研究分析自 1984 年 6 月至 2007 年 8 月期間,46 位頭頸部腺樣囊狀癌之 病人,接受切除手術及 50 Gy 以上的術後放射線治療之結果。我們回顧了這些病人的病歷、放 射線治療紀錄及檢查影像。病人特徵:男女各有 23 位,年齡自 16 歲到 75 歲(中位數 55 歲)。 腫瘤的原發位置,唾液腺有 18 人,鼻腔及鼻竇有 14 人,口腔 8 人,淚腺 3 人,舌底 2 人, 喉部 1 人。本研究主要分析總存活率,其次我們也分析局部無病存活率、無遠處轉移存活率及 腫瘤相關存活率。 結果:自開刀後開始計算,經過中位數 157 個月(6~271 個月)的追蹤,46 位病人中有 24 位 病人腫瘤復發(7 位局部復發,1 位頸部的轉移,9 位是遠處轉移,2 位是局部復發合併頸部 轉移,5 位是局部復發合併遠處轉移)。五年的總存活率、局部無病存活率、無遠處轉移存活 率、腫瘤相關存活率分別是 73.1% 、74.0% 、75.3% 和 80.1% 。在單變項分析中,女性、年紀 輕、早期的腫瘤、較好的身體狀況、原發自唾腺的腫瘤、手術至放射治療期間較短都是較好 的預後因子(P < 0.05)。多變項分析中,只有較好的身體狀況是唯一影響總存活率(HR, 8.47; 95% CI, 1.85-38.64; P= 0.006)及腫瘤相關存活率(HR, 9.23; 95% confidence interval, 1.63-52.10; P = 0.012)的預後因素。 結論:手術加上術後放射治療對頭頸部腺樣囊狀癌有很好的治療結果,五年的總存活率為 75.3% 。較好的身體狀況是總存活率及腫瘤相關存活率最重要以及獨立的預後因素。 [ 放射治療與腫瘤學2010; 17(3): 189-199]
Purpose : To investigate treatment outcome of adenoid cystic carcinoma (ACC) of the head and neck region by surgery plus postoperative radiotherapy. Materials and Methods : From June 1984 to August 2007, a total of 46 patients with ACC of the head and neck were analyzed. There were 23 males and 23 females with a median age of 55 years (range, 16-75). The primary sites included major salivary gland (18), sinonasal region (14), oral cavity (8), lacrimal gland (3), tongue base (2), and larynx (1). The major endpoint was overall survival (OS). The secondary endpoints were local failure-free survival (LFFS), metastasis-free survival (MFS) and cancerspecific survival (CSS). Results : After a median follow-up of 157 months, 24 of 46 patients had tumor relapse (7 local, 1 regional, 2 locoregional, 9 distant, 5 local plus distant). The 5-year rates of LFFS, MFS, OS and CSS were 73.1%, 74.0%, 75.3% and 80.1%, respectively. Univariate analysis revealed that female gender, younger age, early stage, good performance status, major salivary gland location and shorter interval between operation and radiotherapy were favorable prognostic factors for OS (P< 0.05). The multivariate analysis revealed that performance status was the only significant prognostic factor that affected overall survival (hazard ratio, 8.47; 95% confidence interval, 1.85-38.64; P= 0.006) and cancer-specific survival (hazard ratio, 9.23; 95% confidence interval, 1.63- 52.10; P= 0.012). Conclusion: The treatment outcomes of surgery plus postoperative radiotherapy for ACC of head and neck region were good with a 5-year overall survival rate of 75.3%. Performance status was the most important and independent prognostic factor. [Therapeut Radiol Oncol 2010; 17(3): 189-199]


    

本卷期目次
Therapeutic Radiology and Oncology
立體定位放射治療,使用標靶儀或影像導引系統定位治療中心點的誤差比較/ 謝敏文吳孟珈李紳豪林佳生程言鼎林俊彥洪志宏曾振淦
多模式螺旋斷層放射治療儀對鼻咽癌治療在照野外散射劑量之測量/ 謝震球劉明祥梁雲張寶樹黃志仁
THE OUTCOME OF POSTOPERATIVE RADIOTHERAPY FOR ADENOID CYSTIC CARCINOMA OF THE HEAD AND NECK/ Chien-Chih ChenJin-Ching LinJian-Sheng Jan
A SINGLE INSTITUTE EXPERIENCE OF RADIOTHERAPY FOR TREATMENT OF SKULL BASE CHORDOMA AND LITERATURE REVIEW/ Yu-Wen HuKeng-Li LanPin-I HuangCheng-Ying ShiauLing-Wei WangSang-Hue Yen
PROGNOSTIC FACTORS AFFECTING THE OUTCOME OF RECTAL CANCER PATIENTS RECEIVING PREOPERATIVE CHEMORADIOTHERAPY FOLLOWED BY SURGERY/ Shih-Chun LinMu-Tai LiuChu-Ping PiTung-Hao ChangChao-Yuan HuangChih-Chiech HsuChia-Chun Huang
癌症病患接受放射治療後對於服務品質與滿意度之調查研究/ 廖宗義宋建成黃梅月阮國榮方富民
RADIATION RECALL DERMATITIS: A CASE REPORT AND REVIEW OF LITERATURE/ Hsin-Hua NienChing-Jung WuChi-Cheng HuangShih-Hung HuangSuzun Shaw
RADIATION THERAPY FOR TRICHOEPITHELIOMA: CASE REPORT/ Pang Yu ChenYu-Yun Lee(Julia)Ming-Wei YangYuan-Hua WuWei-Ting HsuehForn-Chia LinH.W. Chen(Helen)
A CASE REPORT: URACHAL ADENOCARCINOMA/ Ching-Cheih YangLi-Ching LinKuei-Li LinJenny QueShih-Song Jhuang
 
   
 
   

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