原名「台灣學術線上」
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1
題名:DOSIMETRIC ANALYSIS FOR SPARING THE OBTURATOR NERVES USING IMRT TECHNIQUE FOR CERVICAL CANCER     (22點)
閉孔神經劑量分析於子宮頸癌之保留閉孔神經強度調控放射治療
著者:Wun-Ke Chen(陳文科) ;Chao-Hsing Wang(王朝興) ;Meng-Hao Wu(吳孟浩) ;K. S. Clifford Chao(趙坤山) ;David Huang(黃英強) ;Yu-Jen Chen(陳裕仁)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:閉孔神經 ; 子宮頸癌 ; 強度調控放射治療 ; Obturator nerve ; Cervical carcinoma ; Intensity-modulated radiotherapy
刊名:Therapeutic Radiology and Oncology
頁碼:125-135
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:閉孔神經病變是子宮頸癌放射治療及化學合併放射治療的晚期併發症之一,閉孔內的閉孔神經位於骨盆放射治療之高劑量範圍,藉由界定閉孔內之閉孔神經,以評估降低閉孔神經劑量之治療計畫的結果及可行性。 材料及方法:10 位子宮頸癌病人的電腦斷層影像資料中,依據教科書資料圈選閉孔神經及周邊結構,分析降低閉孔神經放射治療中接受之劑量對治療計畫參數的影響,例如:靶體積或危急器官劑量體積組織圖、最高劑量、標的處方劑量包覆度及順形指標等。 結果:閉孔神經界定指引運用於強度調控放射治療,降低閉孔神經劑量的治療計畫於體外照射接受之最大劑量可減少達 18.3 ± 4.1% ,並且對於計劃靶體積之順形指標、劑量分佈及危急器官之劑量體積關係於統計上並無明顯影響。 結論:降低閉孔神經劑量的治療計畫在強度調控放射治療中是可行的,除可降低閉孔內之閉孔神經所接受劑量,同時不增加其他正常器官劑量及不影響腫瘤處方劑量包覆度。
Purpose: Obturator neuropathy is a late complication of radiotherapy (RT) and chemo-radiation in cervical cancer patients. We studied the feasibility of sparing the obturator nerves in patients receiving intensity-modulated radiotherapy (IMRT) by delineating the obturator nerves in obturator canals near to the high dose region in pelvis irradiation. Materials and Methods: Volumetric computed tomography (CT) images of ten patients with cervical cancers were retrieved. Anatomical orientation of obturator canals were gathered based on published knowledge in textbooks. Target volume of obturator nerves and pertinent normal structures were contoured and reconstructed for IMRT planning. Dosimetric parameters including dose-volume histograms (DVHs), maximal dose, prescription dose coverage and conformal index were compared between plans with and without obturator nerves as organ of avoidance. Result: A guideline for delineation of obturator canals for IMRT on axial contrast CT images was derived. The use of sparing the obturator nerve technique resulted in an average of 18.3 ± 4.1 % decrease in the calculated maximum dose of the obturator nerves (p < 0.05). No significant impact on the conformality and coverage of planning target volume (PTV) of cervical cancer and neither significant dosimetric impact on other critical normal organs in pelvic area. Conclusion: We found that sparing the obturator nerve technique is feasible for patients with cervical cancer and treated with IMRT. The reduction of doses to OBN did not compromise target coverage of tumor and DVHs of other normal organs.


    

本卷期目次
Therapeutic Radiology and Oncology
EARLY EXPERIENCE OF STEREOTACTIC BODY RADIOTHERAPY IN PATIENTS WITH PRIMARY AND METASTATIC LUNG TUMORS/ Hsin-Lun LeeJo-Ting TsaiShang-Wen ChenJia-Wei LinWilson Tiu LaoKum-Min WangChiu-Ping ChenJeng-Fong ChiuTao-Sang Chung
DOSIMETRIC ANALYSIS FOR SPARING THE OBTURATOR NERVES USING IMRT TECHNIQUE FOR CERVICAL CANCER/ Wun-Ke ChenChao-Hsing WangMeng-Hao WuK. S. Clifford ChaoDavid HuangYu-Jen Chen
設計一套特殊針板及平行定位量角器做為攝護腺插種治療輔助工具的研究/ 吳嘉明葉世安蕭光吟郭忠民陳清江趙敏吳敬次
4D CT影像於肺部腫瘤放射治療的應用/ 林俊彥謝敏文程言鼎陳柏元陳臣苑吳卉蓁白冰清王俊傑
18F-FDG PET/CT IMAGES PRODUCED STUNNINGLY FALSE-NEGATIVE RESULTS AFTER DEFINITIVE CHEMORADIOTHERAPY IN NASOPHARYNGEAL CARICINOMA-A CASE REPORT/ Yung-Hsiang LinYuh-Feng WangTa-Wen HsuWen-Yen ChiouMoon-Sing LeeHon-Yi LinTzyy-Ling ChungShih-Kai Hung
INTRACRANIAL HEMANGIOPERICYTOMA: A CASE REPORT AND LITERATURES REVIEW/ Tzu-Wen HsuYu-Chang HuWei-Ming LaiChien-Hsun ChenChung-Man LeungKuo-Chen ChangChing-Hsiung Chang
PROGNOSTIC FACTOR AFFECTING THE OUTCOME OF BONE METASTASIS FROM HEPATOCELLULAR CARCINOMA/ Cheng-Hong LiouMu-Tai LiuWen-Tau HuangAi-Yih WangChao-Yuan HuangChu-Ping PiTung-Hao ChangChih-Chieh HsuChia-Chun Huang
THREE-DIMENSIONAL CONFORMAL RADIOTHERAPY FOR UNRESECTABLE OR POST-OPERATIVE RESIDUAL BILIARY TRACT CARCINOMA/ Chun-chieh HuangEng-Yen HuangFu-Min FangChong-Jong WangHui-Chun ChenChang-Yu WangYu-Ming WangHsuan-Chih Hsu
 
   
 
   

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